A5006467882- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Cardiac Arrest and Resuscitation
- Mesenchymal stem cell research
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Electrospun Nanofibers in Biomedical Applications
- Blood Pressure and Hypertension Studies
- Cardiac electrophysiology and arrhythmias
- Nitric Oxide and Endothelin Effects
- Congenital heart defects research
- Angiogenesis and VEGF in Cancer
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Cell Adhesion Molecules Research
- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Sympathectomy and Hyperhidrosis Treatments
- Atherosclerosis and Cardiovascular Diseases
- Extracellular vesicles in disease
- Coronary Interventions and Diagnostics
University at Buffalo, State University of New York
2016-2025
Buffalo State University
2025
New York University
2024
VA Western New York Healthcare System
2014-2024
Mansoura University
2023
Albany College of Pharmacy and Health Sciences
2021-2023
Northeast Ohio Medical University
2023
Jacobs Institute
2023
King's College London
2022
British Heart Foundation
2022
Endothelin (ET)-1-mediated vasoconstrictor tone contributes to the development and progression of several adiposity-related conditions, including hypertension atherosclerotic vascular disease. The aims present study were determine 1) whether endogenous ET-1 activity is elevated in overweight obese adults, and, if so, 2) increased ET-1-mediated vasoconstriction impairment endothelium-dependent vasodilation. Seventy-nine adults studied: 34 normal weight [body mass index (BMI) < 25 kg/m(2)], 22...
In a porcine model of brief ischemia leading to reversible stunning in the absence tissue necrosis, we demonstrated delayed release cTnI that exceeded 99th percentile for normals 60-minutes after reperfusion and rose readily detectable levels 24-hours later. While analysis at showed no evidence infarction, TUNEL staining isolated myocytes undergoing apoptosis, which was absent 24-hours. These results demonstrate elevations occur duration is insufficient produce myocyte necrosis reflect...
Background: After myocardial infarction (MI), inflammatory cells infiltrate the infarcted heart in response to secreted stimuli. Monocytes are recruited infarct via CCR2 chemokine receptors along a CCL2 concentration gradient. While infiltration of injured tissue with monocytes is an important component reparatory response, excessive or prolonged inflammation can adversely affect left ventricular remodeling and worsen clinical outcomes. Materials methods: Here, we developed poly(ethylene...
Rationale: Allogeneic bone marrow–derived mesenchymal stem cells (MSCs) and cardiosphere-derived (CDCs) have each entered clinical trials, but a direct comparison of these cell types has not been performed in large animal model hibernating myocardium. Objective: Using completely blinded methodology, we compared the efficacy global intracoronary allogeneic MSCs (icMSCs, ≈35×10 6 ) CDCs (icCDCs, versus vehicle cyclosporine-immunosuppressed swine with chronic left anterior descending coronary...
Background: Systemic inflammation is a well-established component of post-cardiac arrest syndrome (PCAS), condition responsible for significant morbidity and mortality in patients who are initially resuscitated from sudden cardiac arrest. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as promising immunomodulatory agents various inflammatory conditions, including after ischemia-reperfusion injury (IRI). Here, we investigated the therapeutic potential MSC-EVs...
Background: Post-cardiac arrest syndrome (PCAS) is characterized by a robust inflammatory response that contributes to significant morbidity and mortality among patients resuscitated from sudden cardiac (SCA). Mitochondrial DNA (mtDNA), with its bacterial-like genomic motifs, has been implicated as damage-associated molecular pattern in other contexts, but role pro-inflammatory stimulus PCAS not studied. Accordingly, the present study was designed determine if rise circulating mtDNA and, so,...
Abstract Aims Activation of the transcriptional factor Krüppel-like 5 (KLF5) is detrimental to chronic heart failure. We explored involvement KLF5 in myocardial ischemia/reperfusion injury. Methods and results Yorkshire pigs underwent 75΄ ischemia, followed by 3h or 24h reperfusion. C57BL/6J mice 30΄ 10’, 2h, 12h, 24h, 4 weeks Hearts isolated cardiomyocytes were analyzed for gene expression. assessed cardiac function, infarct size (IS), oxidative stress, fibrosis subjected pharmacologic...
ET (endothelin)-1, a potent vasoconstrictor peptide released by the endothelium, plays an important role in vasomotor regulation and has been linked to diminished endothelial vasodilator capacity several pathologies associated with human aging, including hypertension, Type 2 diabetes coronary artery disease. However, it is currently unknown whether decline vasodilatation advancing age due elevated ET-1 vasconstrictor activity. Accordingly, we tested hypothesis that age-related impairment ACh...
Background: Myocardial fibrosis is a common postmortem finding among individuals with Sudden Cardiac Death (SCD). Numerous in vivo and vitro studies have shown that increased galectin-3 (gal3) expression into the myocardium associated higher incidence of fibrosis. Although elevated gal3 linked myocardial fibrosis, its role predicting risk SCD unknown. Methods: We reviewed clinical datasets post-mortem examination 221 subjects who had died suddenly. examined pathology including extent cardiac...
Background Cardiosphere-derived cells (CDCs) improve ventricular function and reduce fibrotic volume when administered via an infarct-related artery using the "stop-flow" technique. Unfortunately, myocyte loss dysfunction occur globally in many patients with ischemic non-ischemic cardiomyopathy, necessitating approach to distribute CDCs throughout entire heart. We therefore determined whether global intracoronary infusion of under continuous flow improves contractile stimulates new...
Short sleep duration is associated with increased cardiovascular disease (CVD) morbidity. Endothelial vasomotor dysfunction represents a potential mechanism contributing to the CVD risk habitual short duration. Endothelin (ET)-1 potent vasoconstrictor peptide that endothelial and risk. Currently, there no information regarding influence of on ET-1 activity in adults. We tested hypothesis ET-1-mediated greater adults who less than 7 h/night (short duration) compared those 7–9 (normal...
The aim of this study was to determine if aging is associated with enhanced endothelial progenitor cell (EPC) sensitivity apoptosis. Cells phenotypic EPC characteristics were isolated from healthy, nonobese young (age 25 ± 1 years) and older (61 men. Intracellular active caspase-3 concentrations in response staurosporine stimulation approximately 35% higher (p < 0.05) EPCs (3.15 0.29 pg/ml) compared (2.33 0.24 Protein expression Akt, p70 S6-kinase Bcl-2 markedly lower (approx. 35, 75 60%,...
Rationale: Metformin has been demonstrated to decrease infarct size (IS) and prevent postinfarction left ventricular (LV) remodeling in rodents when given intravenously at the time of reperfusion. It remains unclear whether similar cardioprotection can be achieved a large animal model. Objective: The objective this study was determine intravascular infusion metformin reperfusion reduces myocardial IS porcine model acute infarction. Methods Results: In blinded randomized preclinical study,...