A5002154405- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Photoreceptor and optogenetics research
- Neuroscience, Education and Cognitive Function
- Fuel Cells and Related Materials
- Pain Mechanisms and Treatments
- Science Education and Pedagogy
- Electrochemical Analysis and Applications
- Molecular Communication and Nanonetworks
- Biochemical Analysis and Sensing Techniques
- Neuroscience and Neural Engineering
- Ion Transport and Channel Regulation
- Radiation Effects in Electronics
- Ion channel regulation and function
National Institute of Environmental Health Sciences
2023
National Institutes of Health
2023
Wake Forest University
2016-2022
University of New England
2014
Despite many years of work on dopaminergic mechanisms alcohol addiction, much the evidence remains mostly correlative in nature. Fortunately, recent technological advances have provided opportunity to explore causal role alterations neurotransmission within circuits involved addictive behaviors. Here, we address this critical gap our knowledge by integrating an optogenetic approach and operant self-administration paradigm assess directly how accumbal dopamine (DA) release dynamics influences...
Abstract Intracerebroventricular (ICV) administration of ouabain, an inhibitor the Na, K-ATPase, is approach used to study physiological functions K-ATPase and cardiotonic steroids in central nervous system, known cause mania-like hyperactivity rats. We describe a mouse model ouabain-induced behavior. ICV 0.5 µl 50 µM (25 pmol, 14.6 ng) ouabain into each lateral brain ventricle results increased locomotor activity, stereotypical behavior, decreased anxiety level hour at minimum. Fast-scan...
The current study aimed to explore how presynaptic dopamine (DA) function is altered following brief stress episodes and chronic ethanol self-administration whether these neuroadaptations modify the acute effects of on DA dynamics. We used fast-scan cyclic voltammetry evaluate changes in release uptake parameters rat nucleus accumbens brain slices by analyzing transients evoked through single pulse electrical stimulation. Adult male rats were divided into four groups: ethanol-naïve or...
Classical fear conditioning creates an association between aversive stimulus and a neutral stimulus. Although the requisite neural circuitry is well understood in mature organisms, development of these circuits less studied. The current experiments examine ontogeny relate it to neuronal activation assessed through immediate early gene (IEG) expression amygdala, hippocampus, perirhinal cortex, hypothalamus periweanling rats. Rat pups were conditioned, or not, during third fourth weeks life....
Contextual fear learning is heavily dependent on the hippocampus. Despite evidence that catecholamines contribute to contextual encoding and memory retrieval, precise temporal dynamics of their release in hippocampus during behavior unknown. In addition, new animal models are required probe effects altered catecholamine synthesis learning.
Activity in the mesolimbic dopamine (DA) pathway is known to have a role reward processing and related behaviors. The DA response has been well-examined, while aversive or negative stimuli studied lesser extent produced inconclusive results. However, brief increase concentration terminals during nociceptive activation become an established but not well-characterized phenomenon. Consequently, interpretation of significance this neurochemical still elusive. present study was designed further...
Using fast-scan cyclic voltammetry paired with pharmacology, the authors show that infralimbic catecholamine release following locus coeruleus stimulation is noradrenergic, but not dopaminergic, and affected by acute ethanol. With previous work, these data suggest differential effects of ethanol on prefrontal norepinephrine dopamine, a region important in addiction-related pathways.
Anxiety disorders often emerge during childhood. Rodent models using classical fear conditioning have shown that different types of depend upon neural structures and may at stages development. For example, some work has suggested contextual generally emerges later in development (postnatal day 23–24) than explicitly cued 15–17) rats. This been attributed to an inability younger subjects form a representation the context due immature hippocampus. However, evidence can be observed postnatal 17...
The present study aimed to explore the consequences of a single exposure social defeat on dopamine release in rat nucleus accumbens measured with fast-scan cyclic voltammetry. We found that 24 h after defeat, accumbal responses, evoked by high frequency electrical stimulation ventral tegmental area, were more profound socially defeated rats comparison non-defeated control animals. enhanced was associated prolonged immobility time forced swim test. use depletion protocol revealed no...
The current rodent study applied
Despite many years of work on dopaminergic mechanisms alcohol addiction, much this evidence remains mostly correlative in nature. Fortunately, recent technological advances have provided the opportunity to explore causal role alterations neurotransmission within circuits involved addictive behaviors. Here, we address critical gap our knowledge by integrating optogenetic approach and an operant self-administration paradigm assess directly how accumbal DA release dynamics influence appetitive...
ABSTRACT Contextual fear learning is heavily dependent on the hippocampus. Despite evidence that catecholamines contribute to contextual encoding and memory retrieval, precise temporal dynamics of their release in hippocampus during behavior unknown. In addition, new animal models are required probe effects altered catecholamine synthesis learning. Utilizing GRAB NE DA sensors, vivo fiber photometry, two mouse locus coeruleus norepinephrine (LC-NE) synthesis, we investigate (NE) dopamine...
Commonly used neuromodulation techniques such as electrical stimulation or pharmacologic intervention have some technical limitations that preclude dissecting particular cell-or pathway-specific functions in the brain, which is composed of billions neurons.An advancement molecular genetics has provided a novel method neuroscience called optogenetics.Optogenetics uses combination genetic and optical methods provide means to, with great temporal precision, experimentally control activation...