A5018937135- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Olfactory and Sensory Function Studies
- Neural dynamics and brain function
- Neuropeptides and Animal Physiology
- Neurobiology and Insect Physiology Research
- Genetics and Neurodevelopmental Disorders
- Circadian rhythm and melatonin
- RNA Research and Splicing
- Cholinesterase and Neurodegenerative Diseases
- Advanced Fluorescence Microscopy Techniques
- Photoreceptor and optogenetics research
- Indoor Air Quality and Microbial Exposure
- Multisensory perception and integration
- Peroxisome Proliferator-Activated Receptors
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
National Institutes of Health
2017-2024
National Institute of Environmental Health Sciences
2017-2024
University of California, Los Angeles
2010-2023
W. M. Keck Foundation
2013-2021
Neurobehavioral Systems
2012
University of Victoria
2010
Florida College
2005
University of Florida
2004-2005
The hippocampal cognitive map is thought to be driven by distal visual cues and self-motion cues. However, other sensory also influence place cells. Hence, we measured rat activity in virtual reality (VR), where only nonvestibular provided spatial information, the real world (RW). In VR, cells showed robust selectivity; however, 20% were track active, compared with 45% RW. This indicates that are sufficient provide selectivity, but vestibular present RW necessary fully activate place-cell...
The reproducibility crisis (or replication crisis) in biomedical research is a particularly existential and under-addressed issue the field of behavioral neuroscience, where, spite efforts to standardize testing assay protocols, several known unknown sources confounding environmental factors add variance. Human interference major contributor variability both within across laboratories, as well novelty-induced anxiety. Attempts reduce human measure more "natural" behaviors subjects has led...
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability in humans. This X-linked disorder caused by transcriptional repression a single gene, Fmr1. The loss Fmr1 transcription prevents production mental retardation protein (FMRP) which turn disrupts expression variety key synaptic proteins that appear to be important for ability. A clear link between dysfunction and behavioral impairment has been elusive, despite fact several animal models FXS have generated....
Understanding of adaptive behavior requires the precisely controlled presentation multisensory stimuli combined with simultaneous measurement multiple behavioral modalities. Hence, we developed a virtual reality apparatus that allows for reward checking, commonly used measure in associative learning paradigms, and navigational behavior, along visual, auditory stimuli. Rats performed spatial navigation task analogous to Morris maze where only distal visual or cues provided information....
Recent data demonstrate that noradrenergic neurons of the locus coeruleus (LC-NE) are required for fear-induced suppression feeding, but role endogenous LC-NE activity in natural, homeostatic feeding remains unclear. Here, we found was suppressed during food consumption, and magnitude this neural response attenuated as mice consumed more pellets throughout session, suggesting LC responses to modulated by satiety state. Visual-evoked also sated mice, state modulates encoding multiple...
Postnatal neurogenesis (PNN) contributes neurons to olfactory bulb (OB) and dentate gyrus (DG) throughout juvenile development, but the quantitative amount, temporal dynamics functional roles of this contribution have not been defined. By using transgenic mouse models for cell lineage tracing conditional ablation, we found that gradually increased total number granule by approximately 40% in OB, 25% DG, between 2 weeks months age, numbers remained stable thereafter. These findings indicate...
Contextual fear conditioning is thought to involve the synaptic plasticity-dependent establishment in hippocampus of representations to-be-conditioned contexts which can then become associated with USs amygdala. A conceptual and computational model this process proposed contextual attributes are assumed be sampled serially randomly during exposures. Given assumption, moment-to-moment information about such will often quite different from one exposure another and, particular, between...
ABSTRACT Recombinase activation gene 1 (RAG-1) function is essential for V(D)J recombination in T-cell-receptor and immunoglobulin rearrangements whereby the immune system may encode memories of a vast array antigens. The RAG-1 also localized to neurons hippocampal formation related limbic regions that are involved spatial learning memory as well other parameters neurobehavioral performance. Since unique ability shared by brain, we tested hypothesis loss brain would influence performance...
Background-A major effect of low dose ethanol is impairment hippocampus-dependent cognitive function.α4/δ-containing GABA A R's are highly expressed within the dentate gyrus region hippocampus where they mediate a tonic inhibitory current that sensitive to enhancement by concentrations.These receptors also powerful modulators learning and memory, suggesting could play an important role in ethanol's cognitiveimpairing effects.The goal present study was develop high-throughput assay, amenable...
Learning about context is essential for appropriate behavioral strategies, but important contingencies may not arise during initial learning. A variant of contextual fear conditioning, pre-exposure facilitation, allows us to directly test the relationship between novelty-induced acetylcholine release and later associability. We demonstrate that optogenetically-enhanced exploration leads stronger after subsequent pairing with shock, suggesting primes future associations.
Abstract A key goal in hippocampal research is to understand how neuronal activity generated and organized across subregions enable memory formation retrieval. Neuronal CA2 regulated by spatial social investigation as well novelty (Mankin et al., 2015; Alexander 2016), controls population oscillatory the slow γ ripple ranges within hippocampus (Kay 2016; Oliva Boehringer 2017; 2018). neurons are also required for recognition (Stevenson Caldwell, 2012; Hitti Siegelbaum, 2014; Smith 2016)....
SignificanceFiber photometry (FP) is a widely used technique in modern behavioral neuroscience, employing genetically encoded fluorescent sensors to monitor neural activity and neurotransmitter release awake-behaving animals. However, analyzing data can be both laborious time-consuming.AimWe propose the fiber analysis (FiPhA) app, which general-purpose FP application. The goal develop pipeline suitable for wide range of approaches, including spectrally resolved, camera-based, lock-in...
The absence of α2* nicotinic acetylcholine receptors (nAChRs) in oriens lacunosum moleculare (OLM) GABAergic interneurons ablate the facilitation nicotine-induced hippocampal CA1 long-term potentiation and impair memory. current study delineated whether genetic mutations nAChRs (Chrna2L9'S/L9'S Chrna2KO) influence hippocampus-dependent learning memory synaptic plasticity. We substituted a serine for leucine (L9'S) α2 subunit (encoded by Chrna2 gene) to make hypersensitive nAChR. Using dorsal...
Contextual fear learning is heavily dependent on the hippocampus. Despite evidence that catecholamines contribute to contextual encoding and memory retrieval, precise temporal dynamics of their release in hippocampus during behavior unknown. In addition, new animal models are required probe effects altered catecholamine synthesis learning.