A5088861244- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Circadian rhythm and melatonin
- Diet, Metabolism, and Disease
- Memory and Neural Mechanisms
- Congenital heart defects research
National Institute of Neurological Disorders and Stroke
2023
National Institute of Environmental Health Sciences
2019-2022
National Institutes of Health
2022
Recent data demonstrate that noradrenergic neurons of the locus coeruleus (LC-NE) are required for fear-induced suppression feeding, but role endogenous LC-NE activity in natural, homeostatic feeding remains unclear. Here, we found was suppressed during food consumption, and magnitude this neural response attenuated as mice consumed more pellets throughout session, suggesting LC responses to modulated by satiety state. Visual-evoked also sated mice, state modulates encoding multiple...
Abstract Recent data suggest that LC-NE neurons play a role in fear-induced suppression of feeding, but their endogenous activity naturally behaving animals has not been explored. We found was enhanced during food approach and suppressed consumption, these food-evoked responses were attenuated sated mice. Interestingly, visual-evoked also mice, demonstrating internal satiety state modulates encoding multiple behavioral states. intake could be by brief or longer durations activation. Lastly,...
ABSTRACT Accumulating evidence indicates that disruption of galanin signaling is associated with neuropsychiatric disease, but the precise functions this neuropeptide remain largely unresolved due to lack tools for experimentally disrupting its transmission in a cell type-specific manner. To examine function noradrenergic system, we generated and crossed two novel knock-in mouse lines create animals lacking specifically neurons ( Gal cKO-Dbh ). We observed reduced levels peptide pons,...