A5038302008- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Nicotinic Acetylcholine Receptors Study
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Advanced Chemical Sensor Technologies
- Behavioral Health and Interventions
- Circadian rhythm and melatonin
- Neural dynamics and brain function
- Sex and Gender in Healthcare
- Neurobiology and Insect Physiology Research
Georgetown University
2024
National Institute of Environmental Health Sciences
2021-2023
National Institutes of Health
2021-2023
The reproducibility crisis (or replication crisis) in biomedical research is a particularly existential and under-addressed issue the field of behavioral neuroscience, where, spite efforts to standardize testing assay protocols, several known unknown sources confounding environmental factors add variance. Human interference major contributor variability both within across laboratories, as well novelty-induced anxiety. Attempts reduce human measure more "natural" behaviors subjects has led...
Long-term memories are formed by creating stable memory representations via consolidation, which mainly occurs during sleep following the encoding of labile in hippocampus waking. The entorhinal cortex (EC) has intricate connections with hippocampus, but its role consolidation is largely unknown. Using cell-type- and input-specific vivo neural activity recordings, here we show that temporoammonic pathway neurons EC, directly innervate output area exhibit potent oscillatory activities...
The activation of α7 nicotinic acetylcholine receptors (nAChRs) has been shown to improve hippocampus-dependent learning and memory. nAChRs are densely expressed among several different cell types in the hippocampus, with high Ca2+ permeability, although it is unclear if mobilize differential signalling mechanisms distinct neuronal populations. To address this question, we compared nAChR agonist-induced responses (i.e. calcium cAMP changes) between granule cells GABAergic neurons hippocampal...
Inclusion of male and female subjects in behavioral neuroscience research requires a concerted effort to characterize sex differences standardized assays. Sex hippocampus-dependent assays have been widely reported but are still poorly characterized. In the present study, we conducted parametric analysis spontaneous alternation, object recognition, fear conditioning commonly used control strain, C57BL/6NTac. Our findings show largely similar performance between males females across majority...
Object recognition tasks are widely used assays for studying learning and memory in rodents. typically involves familiarizing mice with a set of objects then presenting novel object or displacing an to location context. Learning inferred by relative increase time investigating the novel/displaced object. These widespread use, but there many inconsistencies way they conducted across labs. Two major contributors this lack consistency method measuring investigation standardization that used....
Introduction: Altered signaling or function of acetylcholine (ACh) has been reported in various neurological diseases, including Alzheimer's disease, Tourette syndrome, epilepsy among others. Many neurons that release ACh also co-transmit the neurotransmitter gamma-aminobutyrate (GABA) at synapses hippocampus, striatum, substantia nigra, and medial prefrontal cortex (mPFC). Although transmission is crucial for higher brain functions such as learning memory, role co-transmitted GABA from...
Abstract Altered signaling or function of acetylcholine (ACh) has been reported in various neurological diseases, including Alzheimer’s disease, Tourette syndrome, epilepsy among others. Many neurons that release ACh also co-transmit the neurotransmitter gamma-aminobutyrate (GABA) at synapses hippocampus, striatum, and medial prefrontal cortex (mPFC). Although transmission is crucial for higher brain functions such as learning memory, role co-transmitted GABA from remains unknown. Thus,...