A5032558734- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Memory Processes and Influences
- Reproductive System and Pregnancy
- Organ Transplantation Techniques and Outcomes
- Asthma and respiratory diseases
- Liver Disease and Transplantation
- Wound Healing and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Vascular Procedures and Complications
- Reconstructive Facial Surgery Techniques
- Reconstructive Surgery and Microvascular Techniques
- Neurogenesis and neuroplasticity mechanisms
- Liver Disease Diagnosis and Treatment
- Endometriosis Research and Treatment
- Crime and Detective Fiction Studies
- Pharmacological Effects and Assays
- Oral health in cancer treatment
- Psychoanalysis, Philosophy, and Politics
- Evacuation and Crowd Dynamics
Keelung Chang Gung Memorial Hospital
2023-2025
Anhui Medical University
2025
Taipei Medical University
2023-2024
National Cheng Kung University Hospital
2018-2024
University of Edinburgh
2009-2023
National United University
2018-2022
Changhua Christian Hospital
2014-2020
Stornoway Historical Society
2017
Genetic Analysis (Norway)
2017
HCL Technologies (India)
2017
Memory for inconsequential events fades, unless these happen before or after other novel surprising events. However, our understanding of the neurobiological mechanisms novelty-enhanced memory persistence is mainly restricted to aversive fear-associated memories. We now outline an “everyday appetitive” behavioral model examine whether and how unrelated novelty facilitates spatial coupled parallel electrophysiological studies long-term potentiation (LTP). Across successive days, rats were...
In humans and in animals, mental schemas can store information within an associative framework that enables rapid efficient assimilation of new information. Using a hippocampal-dependent paired-associate task, we now report the anterior cingulate cortex is part neocortical network schema storage with NMDA receptor-mediated transmission critical for updating, AMPA required expression updating stored
Incentive learning is the process via which animals update changes in value of rewards. Current evidence suggests that, for food rewards rats, this involves amygdala. However, it remains unclear whether undergoes protein synthesis-dependent consolidation and “reconsolidation” processes lateral basal nuclei Accordingly, we examined hypothesis by local infusion protein-synthesis inhibitor after devaluation a reward induced shift from food-deprived to food-sated state an instrumental...
<i>In vivo</i> experience induces changes in synaptic NMDA receptor (NMDAR) subunit components, which are correlated with subsequent modifications of plasticity. However, little is known about how these regulate the induction threshold At hippocampal Schaffer collateral–CA1 synapses, we first examined whether a recent history neuronal activity could affect plasticity through its actions on NMDAR components. We found that prior produced by priming stimulations (PSs) across wide range...
To this day, it remains unresolved whether experimental amnesia reflects failed memory storage or the inability to retrieve otherwise intact memory. Methodological as well conceptual reasons prevented deciding between these two alternatives: The absence of recovery from is typically taken supporting impairment interpretations; however, does not positively demonstrate nonexistence memory, allowing for alternative interpretations retrieval. address shortcoming, we present a novel approach...
Metabolomics provide a promising tool for understanding dementia pathogenesis and identifying novel biomarkers. This study aimed to identify amino acid biomarkers Alzheimer's Disease (AD) Vascular Dementia (VD). By metabolomics, the concentrations of acids were determined in serum AD VD patients as well age-matched healthy controls. Several differences concentration observed compared both controls patients. However, no significant distinction was found between Considering comorbidities,...
Many insignificant events in our daily life are forgotten quickly but can be remembered for longer when other memory-modulating occur before or after them. This phenomenon has been investigated animal models a protocol which weak memories persist if exploration novel context is introduced around the time of memory encoding. study aims to understand whether types rewarding tasks, such as rewarded learning T-maze and object recognition, also effective events. Rats were trained delayed...
Deficits in short-term memory (STM) binding are a distinguishing feature of preclinical stages leading to Alzheimer's disease (AD). However, the neuroanatomical correlates conjunctive STM largely unexplored. Here we examine possible association between volumes hippocampi, parahippocampal gyri, and grey matter within subcortical structures - all found have foci that seemingly correlate with basic daily living activities AD patients cognitive tests related binding.Hippocampal, thalamic, corpus...
Delirium is one of the main causes increased length intensive care unit (ICU) stay among patients who have undergone living donor liver transplantation (LDLT). We aimed to evaluate risk factors for delirium after LDLT as well investigate whether impacts ICU and hospital stay.Seventy-eight underwent during period January 2010 December 2012 at a single medical center were enrolled. The Confusion Assessment Method Intensive Care Unit (CAM-ICU) scale was used diagnose delirium. Preoperative,...
Decline in cognitive functions, including hippocampus-dependent spatial memory, is commonly observed at a later stage of aging (e.g., >20 months old rodents) and typically studied after discrete learning event. How normal aging, particularly an early stage, affects the modulatory aspect memory persistence underinvestigated. Previous studies young animals show that weak, fading memories can last longer if modulating event, such as novelty, introduced around encoding. This known behavioral...
Abstract Our current understanding of brain mechanisms involved in learning and memory has been derived largely from studies using experimentally naïve animals. However, it is becoming increasingly clear that not all identified may generalize to subsequent learning. For example, N ‐methyl‐D‐aspartate glutamate (NMDA) receptors the dorsal hippocampus are required for contextual fear conditioning animals but previously trained a similar task. Here we investigated how learn second time—a...
To investigate the effect of clomiphene citrate on uterine blood flow in women with unexplained infertility. Twenty-one who had normal (pulsatility index [PI]less than 3 from LH peak to middle luteal phase a natural ovulatory cycle) were enrolled this study. Patients given (100 mg/day) days 5–9 next cycle. The PI values measured and citrate-treated cycles compared using repeated measures analysis variance. Their correlations estradiol (E2) progesterone concentrations treatment cycle...