A5007850144- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Stress Responses and Cortisol
- Pharmacology and Obesity Treatment
- Hypothalamic control of reproductive hormones
- Neuroendocrine regulation and behavior
- Cardiovascular Function and Risk Factors
- Obesity and Health Practices
- Hormonal and reproductive studies
- Birth, Development, and Health
- Diabetes Treatment and Management
- Muscle metabolism and nutrition
- Radiopharmaceutical Chemistry and Applications
- Cardiomyopathy and Myosin Studies
- Adrenal and Paraganglionic Tumors
- Body Contouring and Surgery
- Nutrition and Health in Aging
- Obstructive Sleep Apnea Research
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Dietary Effects on Health
- Diabetes Management and Research
- Pituitary Gland Disorders and Treatments
- Prenatal Substance Exposure Effects
- Fatty Acid Research and Health
Oregon Weight Loss Surgery
2009-2022
Harbor–UCLA Medical Center
1981-2015
UCLA Medical Center
1986-2015
Legacy Good Samaritan Medical Center
2010-2013
Legacy Health
2011-2013
Office of Legacy Management
2011
Louisiana State University Health Sciences Center New Orleans
2005-2007
University Medical Center New Orleans
2007
Louisiana State University
2007
St. Charles Hospital
2006
A cross-sectional survey was made in 56 exceptionally healthy males, ranging age from 20 to 84 years. Measurements were of selected steroidal components and peptidic hormones blood serum, cognitive physical tests performed. Of those serum variables that gave highly significant negative correlations with ( r > −0.6), bioavailable testosterone (BT), dehydroepiandrosterone sulfate (DHEAS), the ratio insulin-like growth factor 1 (IGF-1) hormone (GH) showed a stepwise pattern age-related...
Modest weight loss from clinical interventions improves glycemic control in type 2 diabetes (T2DM). Data are sparse on the effects of via commercial programs. This study examined and standard Weight Watchers program, combined with telephone email consultations a certified educator (WW), compared nutrition counseling education (standard care, SC).In 12-month randomized controlled trial at 16 U.S. research centers, 563 adults T2DM (HbA1c 7-11%; BMI 27-50 kg/m2 ) were assigned to either...
Pregnant Sprague‐Dawley rats were administered a liquid alcohol diet (35% ethanol‐derived calories), pair‐fed isocaloric diet, or dry food pellets beginning on Day 14 of gestation and continuing until parturition. Testosterone levels in male fetuses measured Days 17 through 20 gestation. The normal surge testosterone 18 19 was present controls, but notably absent exposed to alcohol. Light microscopic examination the testes at birth revealed reduction number leydig cells group presence large...
Evaluate frequency of diagnostic testing for obstructive sleep apnea (OSA), prevalence OSA, and factors independently associated with OSA status in adults undergoing bariatric surgery. DESIGN, SETTINGS AND INTERVENTIONS: Longitudinal Assessment Bariatric Surgery-2 (LABS-2) is an observational cohort 2,458 surgery at 10 U.S. hospitals. Within 30 days prior to surgery, researchers determined if participants had a polysomnography (PSG) the previous 12 months. When available, apnea-hypopnea...
Norepinephrine infusion in dogs has been shown to cause ventricular septal hypertrophy that mimics the syndrome of hypertrophic cardiomyopathy humans. To characterize mechanisms involved hypertrophy, adrenergic system right and left ventricles septum were analyzed before after norepinephrine infusion. In normal unperturbed state, was found be more sensitive beta-adrenergic stimulation than either or ventricles. That is, cyclic AMP could generated with a smaller dose beta-agonist...
We previously reported that hypothalamic beta-adrenergic receptor stimulation prevents testosterone (T)-induced androgenization (defeminization) of the female neonatal rat hypothalamus. It was hypothesized beta-receptor blocks by reducing nuclear accumulation estradiol (E2) derived from aromatization T. Various adrenergic agonists and antagonists were injected intracerebrally in 4-day-old rats. [3H] T its 3H-metabolites (including E2) extracted pellets, separated one another with thin-layer...
Androgenization of the female neonatal rat brain by testosterone and subsequent development persistent estrus in adult can be blocked drugs which interfere with normal hypothalamic neuronal function. The mechanism action these was studied. A 25-μg dose propionate at 5 days age produced a 69% incidence 90 age. α-Methyl-p-tyrosine given resulted an 81% estrus. Therefore, norepinephrine depletion did not prevent androgenization. Tyramine (100μg) inhibited androgenization to 27% days....
Metabolic syndrome is associated with higher risk for cardiovascular disease, sleep apnea, and nonalcoholic steatohepatitis, all common conditions in patients referred bariatric surgery, it may predict early postoperative complications. The objective of this study was to determine the prevalence metabolic syndrome, defined using updated National Cholesterol Education Program criteria, adults undergoing surgery compare baseline co-morbid select operative 30-day outcomes by status.Complete...
Type 2 diabetes mellitus (T2DM) can substantially decrease quality of life (QOL). This study examined the effects on QOL-relevant psychosocial measures a widely available commercial weight loss program enhanced for individuals with T2DM. A year-long multi-site randomized clinical trial compared Weight Watchers (WW) approach, supplemented phone and email counseling certified educator (CDE), to brief standard nutrition education (Standard Care; SC). Participants were 400 women 163 men (N = 279...
The distribution of hypothalamic norepinephrine and dopamine tissue concentrations the relative differences in turnover rate were studied sexually maturing female rats. A modified radioenzymatic assay was used to measure concentrations. Norepinephrine estimated by calculating disappearance intraventricularly injected [3H]norepinephrine over 24 h, with a correction for dilution specific activity endogenous stores. Hypothalamic catecholamine content values determined median eminence, anterior...
Controversy exists on whether dopamine (DA) stimulates or inhibits GnRH secretion and its effects are mediated via alpha-adrenergic receptors dopaminergic receptors. As a means to examine this conflict, we have utilized an in vitro superfusion system study the of DA, norepinephrine (NE), phentolamine (alpha-antagonist), pimozide (DA antagonist), two DA agonists (apomorphine bromocryptine) release from isolated mediobasal hypothalami adult male rats. In dynamic system, graded concentrations...
Objective: Topical fat reduction from the thigh in women using aminophylline cream has been demonstrated, but local other body areas or men by lowering lipolytic threshold not demonstrated. This study is designed to test hypothesis that application waist will reduce circumference compared with a control. Research methods and procedures: Fifty who are 21–65 years of age BMI greater than 27 kg/m 2 hip ratio ≥average were randomized 1 : 0.5% twice day no treatment waist. All subjects instructed...
Abstract GREENWAY, FRANK, DAVID HEBER, WILLIAM RAUM, AND SILVIA MORALES. Double‐blind, randomized, placebo‐controlled clinical trials with non‐prescription medications for the treatment of obesity. Obes Res . Objective : Phenylpropanolamine (PPA) and benzocaine are approved treating The dose PPA weight loss is 75 mg/day. has same chemical similarity to pseudoephedrine that amphetamine methamphetamine. Because causes by altering taste central appetite suppression, they may induce additional...
A single meal stimulates brown adipose tissue (BAT) thermogenesis in rats. In the present study role of norepinephrine this thermogenic response was assessed from rate its turnover BAT after a test meal. For comparison, determined heart and spleen. total 48 male Wistar rats (200 g) were trained to eat during two feeding sessions per day. On experimental day, one group (n = 24) deprived other given low-protein high-carbohydrate for 2 h. The synthesis inhibition method with...