A5074081812- Heavy Metal Exposure and Toxicity
- Vitamin D Research Studies
- Trace Elements in Health
- Sports Performance and Training
- Tendon Structure and Treatment
- Ultrasound and Hyperthermia Applications
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Genetics and Physical Performance
- Aluminum toxicity and tolerance in plants and animals
- Shoulder Injury and Treatment
- Macrophage Migration Inhibitory Factor
- Cancer Treatment and Pharmacology
- HIV-related health complications and treatments
- Myofascial pain diagnosis and treatment
- Exercise and Physiological Responses
- Reproductive System and Pregnancy
- Anesthesia and Neurotoxicity Research
- Vitamin C and Antioxidants Research
- Histone Deacetylase Inhibitors Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nutrition and Health in Aging
- Medical and Biological Sciences
- Photoacoustic and Ultrasonic Imaging
- Glioma Diagnosis and Treatment
- Barrier Structure and Function Studies
University of Pisa
2021-2024
University of Florence
2009-2019
Cadmium (Cd) is a highly toxic environmental pollutant released from the smelting and refining of metals cigarette smoking. Oral exposure to cadmium may result in adverse effects on number tissues, including central nervous system (CNS). In fact, its toxicity has been related neurological disorders, as well neurodegenerative diseases such Alzheimer's Parkinson's diseases. Under normal conditions, Cd barely reaches brain adults because presence blood-brain barrier (BBB); however, it...
Oxaliplatin is a key drug in the treatment of advanced metastatic colorectal cancer. Despite its beneficial effects tumor reduction, most prevalent side-effect oxaliplatin chemotherapy-induced neuropathy that frequently forces to discontinue therapy. Indeed, along with direct damage peripheral nerves, chemotherapy-related neurotoxicity involves also central nervous system (CNS) as demonstrated by pain chronicity and cognitive impairment (also known chemobrain), newly described...
The role of vitamin D in maintaining health appears greater than originally thought, and the concept axis underlines complexity biological events controlled by biologically active (1,25(OH)(2)D3), its two binding proteins that are receptor (VDR) D-binding protein-derived macrophage activating factor (GcMAF). In this study we demonstrate GcMAF stimulates macrophages, which turn attack human breast cancer cells, induce their apoptosis eventually phagocytize them. These results consistent with...
The protective effect of cannabidiol (CBD), the non-psychoactive component Cannabis sativa, against neuronal toxicity induced by cadmium chloride (CdCl2 10 μM) was investigated in a retinoic acid (RA)-differentiated SH-SY5Y neuroblastoma cell line. CBD (1 applied 24 h before and removed during (Cd) treatment. In differentiated cells, significantly reduced Cd-dependent decrease viability, rapid reactive oxygen species (ROS) increase. prevented endoplasmic reticulum (ER) stress (GRP78...
Micheli, ML, Gulisano, M, Morucci, G, Punzi, T, Ruggiero, Ceroti, Marella, Castellini, E, and Pacini, S. Angiotensin converting enzyme/vitamin D receptor gene polymorphisms bioelectrical impedance analysis in predicting athletic performances of Italian young soccer players. J Strength Cond Res 25(8): 2084-2091, 2011—We evaluated the association between 2 genetic known to be involved fitness performance, anthropometric features, body composition, male players with goal identifying profiles...
In recent years, alcohol abuse has dramatically grown with deleterious consequence for people's health and, in turn, care costs. It been demonstrated, humans and animals, that intoxication induces neuroinflammation neurodegeneration thus leading to brain impairments. Furthermore, it shown consumption is able impair the blood-brain barrier (BBB), but molecular mechanisms underlining this detrimental effect have not fully elucidated. For reason, study we investigated effects of exposure on a...
α-N-acetylgalactosaminidase (nagalase) accumulates in the serum of cancer patients and its activity correlates with tumor burden, aggressiveness clinical disease progression. The administration GC protein-derived macrophage-activating factor (GcMAF) to elevated levels nagalase has been associated a decrease significant benefits. Here, we report results GcMAF heterogeneous cohort histologically diverse, advanced neoplasms, generally considered as "incurable" diseases. In most cases, therapy...
Background and Objectives: Aging is a biological irreversible process characterized by physiological alterations resulting in progressive decline functions, decreased resistance or adaptability to stress, increased disease susceptibility. A functional fitness, imbalance between pro- antioxidant capacity, and/or hormonal dysregulation adversely impact physical emotional status, overall quality of life, especially within the elderly population. On other hand, regular activity considered an...
Research studies show that serious games can increase patient motivation regardless of age or illness and be an affordable promising solution with respect to conventional physiotherapy. In this paper, we present the latest evolution our system for shoulder rehabilitation based on hand-finger tracking projected augmented reality. This version integrates metrics assess performance, monitors game progress, allows selection visualization mode (standard on-screen reality). Additionally, new...
Ledderhose disease (LD, or plantar fibromatosis) is a rare, nodular, hyperproliferative condition affecting the aponeurosis of foot. At present, several conservative, non-surgical treatments have been documented, although with various degrees success, little evidence in literature supporting their efficacy. In this scenario, extracorporeal shock wave therapy (ESWT) has emerged as safe, effective, and less invasive approach for successful treatment refractory musculoskeletal conditions soft...
Cadmium is an environmental pollutant inducing numerous pathological effects, including neurological disorders and brain diseases. However, little known about the molecular mechanisms of cadmium in affecting neurons neurotoxicity development human brain. We have recently established, cloned, propagated vitro a primary long-term cell culture (FNC-B4) obtained from fetal olfactory neuroepithelium. In present study, we show that different concentrations chloride (CdCl(2)) induced dose-dependent...
Cadmium, a highly persistent heavy metal, has been categorized as human carcinogen. Even though it is known that cadmium acts estrogens in breast cancer cells, several studies failed to demonstrate whether causal factor for cancer. The lack of strong association between and could be found the antiangiogenic properties this which might counteract its carcinogenic progression In study, we exposed estrogen-responsive cells subtoxic levels cadmium, evaluated their angiogenic potential using...
Proteins highly represented in milk such as α-lactalbumin and lactoferrin bind Oleic Acid (OA) to form complexes with selective anti-tumor activity. A protein present milk, colostrum blood, vitamin D binding is the precursor of a potent Macrophage Activating Factor (GcMAF) analogy other OA-protein complexes, we proposed that OA-GcMAF could demonstrate greater immunotherapeutic activity than GcMAF alone. We describe preliminary experience treating patients advanced cancers, often labelled...