A5030268847- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Autoimmune and Inflammatory Disorders
- Food Allergy and Anaphylaxis Research
- Immune Cell Function and Interaction
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Oral Health Pathology and Treatment
- T-cell and B-cell Immunology
- Eosinophilic Disorders and Syndromes
- Skin Diseases and Diabetes
- Tumors and Oncological Cases
- Thermal Regulation in Medicine
- Thermoregulation and physiological responses
- Genetic and rare skin diseases.
- Cancer and Skin Lesions
- Chemotherapy-related skin toxicity
- Genital Health and Disease
- IL-33, ST2, and ILC Pathways
- Climate Change and Health Impacts
- Tryptophan and brain disorders
- Nail Diseases and Treatments
University of Pennsylvania
2019-2024
California University of Pennsylvania
2023
Translational Therapeutics (United States)
2020
Villanova University
2018
Introduction: Components of the immune response have previously been associated with pathophysiology atopic dermatitis (AD), specifically Human Leukocyte Antigen (HLA) Class II region via genome-wide association studies, however exact elements not identified. Methods: This study examines genetic variation HLA genes using next generation sequencing (NGS) and evaluates resultant amino acids, particular attention on binding site residues, for associations AD. The Genetics AD cohort was used to...
Abstract Atopic dermatitis (AD) is a disease of immune dysregulation and skin barrier dysfunction with relapsing, remitting course has been associated several different genetic risk variants. HLA represent highly variable set genes that code for cell surface protein molecules involved in the Ag-specific response, including regulation or functioning T cells, NK APCs. The purpose this study was to evaluate associations between class I polymorphisms progression AD over time. We evaluated...
Atopic dermatitis (AD) is a common relapsing inflammatory skin disease. FLG the gene most consistently associated with AD. Loss-of-function variants in have been previously Low-frequency and rare alleles (minor allele frequency < 5%) this given less attention than loss-of-function variants. We fine sequenced cohort of individuals developed machine learning‒based algorithm to associate low-frequency then applied data, searching for associations between groups AD remission. A group 46 was...
Abstract Natural killer cells (NK) have been associated with the pathophysiology of atopic dermatitis (AD). NK function is regulated by cell Ig-like receptor family (KIR) receptors that interact HLA ligands. The study goal was to focus on allelic variation in genes KIR2DL5 , KIR2DS5 and KIR2DS1 respect AD. This a case–control individuals (n = 313) without 176) Associations were estimated using logistic regression. prevalence 52.5% (95% CI 48.0,57.0), 33.0% (28.8,37.3), 33.6% (29.4,38.0)....
Methotrexate (MTX) is a folic acid antagonist that commonly prescribed at low doses for autoimmune conditions such as rheumatoid arthritis (RA) and psoriasis. Oral ulcerations are common dose-dependent mucocutaneous side effect of MTX, particularly in patients receiving it high with inadequate supplementation.1 Cutaneous less have been reported primarily psoriasis cutaneous sign marrow toxicity.2 Herein, we present rare case MTX-induced ulceration without concurrent pancytopenia patient RA.
This cohort study evaluates annual health care utilization and costs associated with common cutaneous anogenital wart treatments, such as cryotherapy, intralesional immunotherapy, prescription topical treatments.