A5027056444- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Asymmetric Synthesis and Catalysis
- Sulfur-Based Synthesis Techniques
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis of heterocyclic compounds
- Chemical synthesis and alkaloids
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Catalytic Alkyne Reactions
- Crystallography and molecular interactions
- Radical Photochemical Reactions
- Enzyme Catalysis and Immobilization
- Bioactive Compounds and Antitumor Agents
- Asymmetric Hydrogenation and Catalysis
- Microbial Metabolic Engineering and Bioproduction
- Synthesis and Biological Evaluation
- Synthesis of β-Lactam Compounds
- Click Chemistry and Applications
- Synthesis and Reactions of Organic Compounds
- Synthesis and Reactivity of Heterocycles
- Oxidative Organic Chemistry Reactions
- Synthetic Organic Chemistry Methods
Queen's University
2010-2020
University of York
2014-2019
University of Nottingham
2006-2008
University of Exeter
2004-2006
Abstract Mitochondrial fission is important in physiological processes, including coordination of mitochondrial and nuclear division during mitosis, pathologic such as the production reactive oxygen species (ROS) cardiac ischemia‐reperfusion injury (IR). mainly mediated by dynamin‐related protein 1 (Drp1), a large GTPase. The GTPase activity Drp1 essential for its fissogenic activity. Therefore, we aimed to identify inhibitors evaluate their anti‐neoplastic cardioprotective properties five...
Systematic studies are presented demonstrating the complementarity of directed ortho metalation (DoM) and Ir-catalyzed strategies for provision borylated aromatics their subsequent Suzuki-Miyaura coupling reactions. A new concept, use TMS group, readily introduced by DoM, as a latent regiodirective moiety to overcome otherwise problematic production isomeric product mixtures is presented. Additional electrophile-induced ipso-deborylation DoM reactions Bpin products described.
ABSTRACT Most mycolic acid-containing actinobacteria and some proteobacteria use steroids as growth substrates, but the catabolism of last two steroid rings has yet to be elucidated. In Mycobacterium tuberculosis , this pathway includes virulence determinants been proposed encoded by KstR2-regulated genes, which include a predicted coenzyme A (CoA) transferase gene ( ipdAB ) an acyl-CoA reductase ipdC ). presence cholesterol, Δ mutants either M. or Rhodococcus jostii strain RHA1 accumulated...
Unexpected Smiles! An unusual and highly regioselective synthesis of dibenzoxazepinones by a domino sequence assisted an unexpected Smiles rearrangement is reported. The process effective on electronically differentiated phenols shows high tolerance to variation in the benzamide substituents. A plausible path for reaction, supported preliminary mechanistic data, offered.
Abstract A copper(II)‐catalysed approach to oxindoles, thio‐oxindoles, 3,4‐dihydro‐1 H ‐quinolin‐2‐ones, and 1,2,3,4‐tetrahydroquinolines via formal CH, ArH coupling is described. In a new variant, copper(II) 2‐ethylhexanoate has been identified as an inexpensive efficient catalyst for this transformation, which utilises atmospheric oxygen the re‐oxidant.
A double C–H, Ar–H coupling process for the conversion of bis-anilides into spirocyclic bis-oxindoles, enabling concomitant formation two all-carbon quaternary centers at oxindole 3-positions in a diastereoselective manner, is described. The optimum cyclization conditions utilize stoichiometric Cu(OAc)2·H2O/KOtBu DMF 110 °C and have been applied to prepare range structurally diverse bis-spirooxindoles fair good yields (28–77%); method has also extended bis-oxindoles linked by functionalized...
Reported is the synthesis of carboxylic acids, symmetrical ketones, and unsymmetrical ketones with selectivity achieved by exploiting differential reactivity sodium methyl carbonate Grignard organolithium reagents.
The naturally occurring 1,4-benzoquinones 2-methoxy-6-propyl-1,4-benzoquinone (1), 2-methoxy-6-pentyl-1,4-benzoquinone (primin 2), 2-methoxy-6-pentadecyl-1,4-benzoquinone (3), 2-methoxy-6-heptadecyl-1,4-benzoquinone (dihydroirisquinone, pallasone B; 4) were synthesized by a simple protocol involving microwave accelerated Claisen rearrangement of allyl ethers 10, followed hydrogenation the side chain alkene, and oxidation to quinone. Claisen-based methodology was extended first synthesis...
Abstract Simple, inexpensive catalysts formed in situ from tricyclohexylphosphine and palladium acetate or a phosphite‐based palladacycle show unprecedented activity the Suzuki coupling of deactivated, non‐activated activated aryl chloride substrates under microwave heating.
Unerwartete Smiles-Umlagerung: Eine ungewöhnliche und hoch regioselektive Synthese von Dibenzoxazepinonen (siehe Schema; dbm=Dibenzoylmethan) verläuft über eine Dominosequenz, an der unerwartete Smiles-Umlagerung beteiligt ist. Der Prozess eignet sich für elektronisch differenzierte Phenole ist gut verträglich mit einer Variation Benzamidsubstituenten. Auf Grundlage erster mechanistischer Daten wird ein plausibler Reaktionspfad vorgeschlagen.
The synthesis of acridanes and related compounds through a Cu‐catalysed radical cross‐dehydrogenative coupling simple 2‐[2‐(arylamino)aryl]malonates is reported. This method can be further streamlined to one‐pot protocol involving the in situ fomation 2‐[2‐(arylamino)aryl]malonate by α‐arylation diethyl malonate with 2‐bromodiarylamines under Pd catalysis, followed cyclisation.
Reported is the transition-metal-free synthesis of substituted dibenzoxazepinones using a convergent domino S<sub>N</sub>Ar–Smiles rearrangement–S<sub>N</sub>Ar process. Substrate-scope investigations demonstrated critical importance ring electronic effects on efficiency In addition, orthogonality this approach with transition-metal-catalyzed procedures was established.
The general synthesis of diversely substituted dibenzoxepinones by a combined Pd‐catalyzed α‐arylation and S N Ar strategy is reported applied to the Manske's ketone, key intermediate en route total cularine alkaloids. In course this work, an unanticipated ring contraction reaction xanthone was observed serves as caveat for conditions widely used reaction.
LigY catalyzes the hydrolysis of a meta-cleavage product (MCP), 4,11-dicarboxy-8-hydroxy-9-methoxy-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate (DCHM-HOPDA), in bacterial catabolism lignin-derived biphenyl. Most characterized MCP hydrolases are serine-dependent, with proceeding via enol–keto tautomerization followed by an acyl-enzyme intermediate. In contrast, is Zn2+-dependent, proposed to proceed formation gem-diol Transient-state kinetic analysis DCHM-HOPDA turnover revealed intermediate...
A series of alkylated 2,3-dihydroxybiphenyls has been prepared on the gram scale by using an effective Directed ortho Metalation-Suzuki-Miyaura cross-coupling strategy. These compounds have used to investigate substrate specificity meta-cleavage dioxygenase BphC, a key enzyme in microbial catabolism biphenyl. Isolation and characterization products will allow further study related processes, including lignin-derived biphenyls.
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Key words tetrahydropyridazines - rhodium catalysis Lewis acid
Abstract The spirocyclic bis‐oxindoles (II) are readily prepared by a copper‐mediated double cyclization of bis‐anilides (I).