A5063458242- Electron and X-Ray Spectroscopy Techniques
- Mass Spectrometry Techniques and Applications
- Atomic and Molecular Physics
- Radiation Therapy and Dosimetry
- Advanced Chemical Physics Studies
- X-ray Spectroscopy and Fluorescence Analysis
- Mitochondrial Function and Pathology
- Radiopharmaceutical Chemistry and Applications
- Pulmonary Hypertension Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Molecular Junctions and Nanostructures
- Radioactive contamination and transfer
- HER2/EGFR in Cancer Research
- Plasma Applications and Diagnostics
- Nanoparticle-Based Drug Delivery
- Water Quality Monitoring and Analysis
- Nitric Oxide and Endothelin Effects
- Advanced biosensing and bioanalysis techniques
- Ion-surface interactions and analysis
- Peptidase Inhibition and Analysis
- Nanocluster Synthesis and Applications
- Pigment Synthesis and Properties
- Analytical Chemistry and Sensors
- Infectious Encephalopathies and Encephalitis
- Cardiovascular Conditions and Treatments
Queen's University
2019-2024
University of Saskatchewan
2017-2021
Damghan University
2018
Islamic Azad University Pharmaceutical Sciences Branch
2018
University of Guelph
2015-2016
Université de Sherbrooke
2011-2015
Universität Innsbruck
2007-2011
The Open University
2011
Nuclear Science and Technology Research Institute
2007
Atomic Energy Organization of Iran
2006
We report the effect of DNA hydration level on damage yields induced by soft X-rays and photoemitted low-energy electrons (LEEs) in thin films plasmid irradiated N2 at atmospheric pressure under different humidity levels. Contrary to a dilute solution DNA, number H2O molecules per nucleotide (Γ) these can be varied from Γ = 2.5 ∼33, where ≤ 20 corresponds layers 33 an additional bulk-like water layer. Our results indicate that LEEs does not increase significantly until second shell is...
Abstract Mitochondrial fission is important in physiological processes, including coordination of mitochondrial and nuclear division during mitosis, pathologic such as the production reactive oxygen species (ROS) cardiac ischemia‐reperfusion injury (IR). mainly mediated by dynamin‐related protein 1 (Drp1), a large GTPase. The GTPase activity Drp1 essential for its fissogenic activity. Therefore, we aimed to identify inhibitors evaluate their anti‐neoplastic cardioprotective properties five...
The sensitization of malignant cells to ionizing radiation is the clinical rationale for use platinum-drug-based concurrent chemoradiotherapy (CCRT) cancer treatment; however, specific mechanisms radiosensitization and their respective contributions still remain unknown. Biological such as inhibition DNA repair may contribute efficacy CCRT; nevertheless, there a dearth information on possible contribution nanoscopic generation lethal lesions, double-strand breaks (DSB). present study...
Nanoparticles (NPs) have received great attention in biological and medical applications because of their unique features. However, induced adverse effects on the system are not well-explored. Herein, interaction silicon dioxide nanoparticles (SiO2 NPs) with human hemoglobin (Hb) lymphocyte cell line was evaluated under physiological conditions by multispectroscopic [intrinsic synchronous fluorescence spectroscopy circular dichrosim (CD)], molecular docking, cellular...
DNA damage induced by low energy electrons (LEEs) and soft X-rays is measured under dry nitrogen oxygen at atmospheric pressure temperature. Five-monolayer plasmid films deposited on tantalum glass substrates are exposed to Al K(α) of 1.5 keV in the two different environments. From yields for DNA, G values extracted LEEs. The LEEs 3.5 3.4 higher than those X-ray photons N(2) O(2) atmospheres, respectively. Because most form single strand breaks (SSB), this result indicates a much...
Epidermal growth factor receptor (EGFR) upregulation is associated with enhanced proliferation and drug resistance in a number of cancers. Nimotuzumab humanized monoclonal antibody high affinity for EGFR. The objective this study was to determine if 89Zr-DFO-nimotuzumab could be suitable human use as PET probe quantifying EGFR vivo.To evaluate the pharmacokinetics, biodistribution, microPET imaging, radiation dosimetry, normal tissue toxicity tumor non-tumor bearing mice...
Single- and double-strand breaks induced by soft X-rays (1.5 keV) photo-emitted LEEs (0-30 eV) were measured in dry humid thin films of plasmid DNA irradiated under different controllable levels oxygen at standard ambient temperature pressure (SATP). G values derived from these experiments shows that the presence H2O changing atmosphere N2 to O2, while keeping all other experimental parameters constant, increases formation DSBs factors 4.5 11.8 for LEEs, respectively. Under an oxygenated...
Epidermal growth factor receptor I (EGFR) is overexpressed in most cancers of epithelial origin. Antibody drug conjugates (ADCs) with PEGylated-maytansine (PEG-DM1) show promise vitro and vivo. However, vivo biodistribution data for ADCs PEG-DM1 have not been reported. Development methods to understand the real-time behavior these needed move compounds clinic. <b>Methods:</b> Here we used noninvasive small-animal SPECT/CT imaging ex PEG<sub>6</sub>-DM1 ADCs. We developed nimotuzumab...
Insulin growth factor receptor (IGF-1R) is overexpressed in many cancers of epithelial origin, where it confers enhanced proliferation and resistance to therapies targeted at other receptors. Anti-IGF-1R monoclonal antibodies have not demonstrated significant improvements patient outcomes clinical trials. Humanized antibody cixutumumab (IMC-A12) binds IGF-1R with low nM affinity. In this study, was conjugated p-SCN-Bn-DOTA radiolabeled 111In or 225Ac for imaging radiotherapy using a...
Drp1 (dynamin-related protein 1), a large GTPase, mediates the increased mitochondrial fission, which contributes to hyperproliferation of pulmonary artery smooth muscle cells in arterial hypertension (PAH). We developed potent GTPase inhibitor, Drpitor1a, but its specificity, pharmacokinetics, and efficacy PAH are unknown.
Dissociative electron attachment to dialanine and alanine anhydride has been studied in the gas phase utilizing a double focusing two sector field mass spectrometer. We show that low-energy electrons (i.e., with kinetic energies from near zero up 13 eV) attach these molecules subsequently dissociate form number of anionic fragments. Anion efficiency curves are recorded for most abundant anions by measuring ion yield as function incident energy. The present experiments single amino acids (M),...
Brain injury/concussion is a growing epidemic throughout the world. Although evidence supports association between traumatic brain injury (TBI) and disturbance in glucose metabolism, underlying molecular mechanisms are not well established. Previously, we reported release of cellular prion protein (PrPc) from to circulation following TBI. The PrPc level was also found be decreased insulin-resistant rat brains. In present study, investigated link insulin resistance single repeated mild...
A novel technique has been employed to investigate the simultaneous damage DNA components induced by soft X rays (1.5 keV) and low-energy electrons (0-30 eV) in thin films of thymidine deposited on glass tantalum substrates irradiated under atmospheric pressure temperature. The were surrounded either an N2 or O2 environment. formation four radiation-induced products is reported this article: base release, 5-hydroxymethyl-2'-deoxyuridine (5-HMdUrd), 5-formyl-2'-deoxyuridine (5-FordUrd)...
Plasma medicine is a multidisciplinary field of research which combining plasma physics and chemistry with biology clinical to launch new cancer treatment modality. It mainly relies on utilizing low temperature plasmas in atmospheric pressure generate instill cocktail reactive species selectively target malignant cells for inhibition the cell proliferation tumor progression. Following summarized review primary vitro vivo studies antitumor effects plasmas, this article briefly outlines...
To develop imaging and therapeutic agents, antibodies are often conjugated randomly to a chelator/radioisotope or drug using primary amine (NH2) of lysine sulfhydryl (SH) cysteine. Random conjugation NH2 SH groups can require extreme conditions may affect target recognition/binding must therefore be tested. In the present study, nimotuzumab was site-specifically labeled ∆N-SpyCatcher/SpyTag with different chelators radiometals. Nimotuzumab is well-tolerated anti-EGFR antibody low skin...