A5075886649- Climate Change and Health Impacts
- Hormonal and reproductive studies
- Sexual function and dysfunction studies
- Ureteral procedures and complications
- Urinary Bladder and Prostate Research
- Wnt/β-catenin signaling in development and cancer
- Renal Transplantation Outcomes and Treatments
- Sexuality, Behavior, and Technology
- Tissue Engineering and Regenerative Medicine
- Corneal Surgery and Treatments
- Mesenchymal stem cell research
- CNS Lymphoma Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Natural product bioactivities and synthesis
- Moyamoya disease diagnosis and treatment
- Urological Disorders and Treatments
- Estrogen and related hormone effects
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Pelvic floor disorders treatments
- Wound Healing and Treatments
- Adenosine and Purinergic Signaling
- Gut microbiota and health
- Ferroptosis and cancer prognosis
- Colorectal Cancer Screening and Detection
Shanghai First People's Hospital
2022-2025
Shanghai Jiao Tong University
2023-2025
Huashan Hospital
2020-2023
Fudan University
2020-2023
Children's Hospital of Fudan University
2022-2023
The high prevalence of erectile dysfunction (ED) in patients with type 2 diabetes mellitus (DM2) is a challenging clinical problem. Researches on extracellular vesicles from urine-derived stem cells (USC-EVs) have shown that they significant therapeutic effects variety diseases by injection including ED. Hyaluronic acid (HA) especially useful for delivering bioactive molecules. This study investigated the and related mechanisms local administration human USC-EVs combined HA (USC-EVs-HA) rat...
The combination of Xiaozheng decoction with postoperative intravesical instillation has been shown to improve the prognosis bladder cancer patients and prevent recurrence. However, mechanisms underlying efficacy this herbal formula remain largely unclear. This research aims identify important components explore their anti-bladder effect mechanism using network pharmacology-based experiments.The chemical ingredients each herb in were collected from Traditional Chinese Medicine (TCM) database....
For decades, the urinary system was regarded as a sterile environment due to absence of any bacterial growth in clinical standard urine cultures from healthy individuals. However, diverse array microbes colonizes small quantities, exhibiting variable compositional signature influenced by differences sex, age, and pathological state. Increasing pieces evidence suggest microbiota exists tumor tissue plays crucial role microenvironment based on research multiple cancer models. Current studies...
Abstract G protein-coupled receptors (GPRs) are one of the largest surface receptor superfamilies, and many them play essential roles in biological processes, including immune responses. In this study, we aim to construct a GPR- tumor environment (TME-i)-associated risk signature predict prognosis patients with endometrial carcinoma (EC). The GPR score was generated by applying univariate Cox regression Least Absolute Shrinkage Selection Operator (LASSO) succession. This involved identifying...
Abstract Background Human epithelial cell sheets (ECSs) are used to clinically treat conditions such as burns, corneal blindness, middle ear cholesteatoma and vitiligo. As a widely material in clinic, there is little information on the biobanking of ECSs its repair effect after storage. Results Two methods for foreskin were compared short term (7 days): 4-degree storage programmed cryopreservation. Cell sheet integrity, viability, apoptosis, immunogenicity, mechanical properties function...
Objective . To optimize the allocation of nursing resources, we investigate an alternative strategy for indwelling catheter cleaning. Methods The present study involved a total 117 male patients and 54 female patients, who were catheterized after urinary surgery from Aug 2018 to Feb 2019. samples cleaning solutions divided by two parts microbiological culture microbiome analysis. Results No pathogenic bacteria observed in 24 h‐uncleaned group 48 group. analysis also showed no significant...
Abstract Objective to explore whether 5-Aminolevulinic acid combined with ferrous iron(5-ALA/Fe 2+ ) could protect testicular tissues damage of mice subjected heat stress (HS) and provide its underlying mechanisms. Methods 5-ALA/Fe was administered intragastrically for 10 days, then exposed a scrotal at 43℃ 20 minutes on third day. Testes were harvested morphologic histopathological examination, oxidative stress, apoptosis, heme oxygenase-1 (HO-1) inflammation detection. The...
Abstract Background: The high prevalence of erectile dysfunction (ED) in patients with type 2 diabetes mellitus (DM2) is a challenging clinical problem. Researches on exosomes from urinary-derived stem cells (USC-Exo) have shown that they significant therapeutic effects variety diseases including ED by injection. Hyaluronic acid (HA) especially useful for delivering bioactive molecules. This study investigated the and related mechanisms local administration human USC-Exo combined HA...