A5034632271- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Parvovirus B19 Infection Studies
- Neonatal Health and Biochemistry
- Blood disorders and treatments
- Maternal and Perinatal Health Interventions
- Hemoglobinopathies and Related Disorders
- Prenatal Screening and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Herpesvirus Infections and Treatments
- Child and Adolescent Health
- Platelet Disorders and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Health, psychology, and well-being
- Spine and Intervertebral Disc Pathology
- Emergency and Acute Care Studies
- Anorectal Disease Treatments and Outcomes
- Genital Health and Disease
- Blood donation and transfusion practices
- Food Allergy and Anaphylaxis Research
- Nursing Roles and Practices
- Vaccine Coverage and Hesitancy
- Hepatitis B Virus Studies
- Immunodeficiency and Autoimmune Disorders
- Pelvic floor disorders treatments
University of Amsterdam
2008-2024
Sanquin
2009-2024
Amsterdam UMC Location University of Amsterdam
2008-2024
Academie Verloskunde Amsterdam Groningen
2020
Huisarts en Wetenschap
2017
University Medical Center Groningen
2015-2016
Weatherford College
2008-2009
Erasmus University Rotterdam
2009
BACKGROUND: Hemolytic disease of the fetus and newborn (HDFN) is a severe disease, resulting from maternal red cell (RBC) alloantibodies directed against fetal RBCs. The effect first‐trimester antibody screening program on timely detection HDFN caused by antibodies other than anti‐D was evaluated. STUDY DESIGN AND METHODS: Nationwide, all women (1,002 in 305,000 consecutive pregnancies during 18 months) with anti‐D, detected screen, were included prospective index‐cohort study. In...
Fetal or neonatal alloimmune thrombocytopenia ( FNAIT ) is a potentially life‐threatening disease where fetal platelets are destroyed by maternal anti‐platelet IgG alloantibodies. The clinical outcome varies from asymptomatic, to petechiae intracranial haemorrhage, but no marker has shown reliable correlation with severity, making screening for impractical and highly inefficient. We recently found Fc‐glycosylation towards platelet red blood cell antigens be skewed decreased fucosylation,...
The objective was the evaluation of effect Dutch national routine antenatal RhIG (anti-D) immunization prevention (RAADP) program comprising one single dose 200 microg (1000 IU) in 30th week pregnancy, restricted to women without a living child.A nationwide historic control study performed. All newly detected anti-D-immunized para-1 1999, 2002, and 2004 were included classified on basis received prophylaxis during first pregnancy: postnatal versus only RhIG. numbers D- parae-1 who delivered...
Summary Haemolytic disease of the fetus and newborn (HDFN) is a severe in which fetal red blood cells (RBC) are destroyed by maternal anti‐RBC IgG alloantibodies. HDFN most often caused anti‐D but may also occur due to anti‐K, ‐c‐ or ‐E. We recently found N ‐linked glycosylation be skewed towards low fucosylation, thereby increasing affinity IgG‐Fc receptor IIIa IIIb, correlated with severity. Here, we analysed 230 pregnant women anti‐c, ‐E –K alloantibodies from prospective screening cohort...
Abstract Objective To evaluate which risk factors for RhD immunisation remain, despite adequate routine antenatal and postnatal RhIg prophylaxis (1000 IU RhIg) additional administration of RhIg. The second objective was assessment the current prevalence immunisations. Design Prospective cohort study. Setting Netherlands. Population Two‐year nationwide alloimmunised RhD‐negative women. Methods women in their first immunised pregnancy were included factor analysis. We compared immunisation,...
Background and Objectives In Europe, postnatal subsequently antenatal administration of anti‐RH1 (D) immunoglobulins (Ig) has reduced the number maternal immunizations incidence haemolytic disease foetus newborn since 1960s. Non‐invasive foetal RHD genotyping now enables prophylaxis to be targeted only women carrying ‐positive foetus. We aimed at describing how Rh prevention is currently managed in different European countries. Materials Methods prepared an online survey on guidelines...
To evaluate the severity of haemolytic disease foetus and newborn (HDFN) in subsequent pregnancies with RhD immunization to identify predictive factors for severe disease.
Koelewijn, J.M.; Vrijkotte, T.G.; de Haas, M.; van der Schoot, C.E.; Bonsel, G.J. Author Information
BACKGROUND Hemolytic disease of the fetus and newborn (HDFN) is caused by maternal antibodies against fetal red blood cell antigens, most often anti‐D, ‐K, or ‐c. ABO incompatibility between mother child anti‐D immunoprophylaxis (RhIG) are known to reduce risk D immunization subsequent HDFN. However, no has been developed prevent non‐D immunizations. STUDY DESIGN AND METHODS We evaluated whether a preventive effect on formation alloantibodies, performing case‐control study including pregnant...
A successful routine RBC alloantibody screening programme should not lead to unnecessary emotional burden during pregnancy due inadequate counselling on the risk of severe haemolytic disease foetus and newborn (HDFN). Rareness this may result in insufficient knowledge subsequent information transfer women, diagnosed with antibodies. We investigated current knowledge, views experiences Dutch obstetric care providers regarding alloimmunization pregnancy.We performed a quantitative...
Hemolytic disease of the fetus and newborn (HDFN) is a serious disorder resulting from maternal red blood cell alloantibodies directed against fetal cells. Alloimmunization D antigen has been responsible for most cases severe HDFN but, as methods preventing immunization have developed, other than anti-D, namely anti-K anti-c in particular, emerged an important cause HDFN. This report details effect first-trimester antibody screening program instituted Netherlands to detect antibodies anti-D...
AIMS To quantify the preferences and preparations for support during labor first hours after childbirth of pregnant women specific preference continuous support. investigate association with parity intended place birth. DESIGN Cross-sectional survey. METHODS Twelve midwifery practices in northern Netherlands recruited women. Measurements structured questionnaire were preparation (timing, including support, provider, type support) RESULTS Two hundred five 247 eligible participated....
BACKGROUND: The Netherlands maintain a high rate of home births relative to other well-resourced countries. Maternity care assistants (MCAs) play an important role, as part the maternity team, assisting midwife during birth and providing postpartum women babies in their homes. A Cochrane review recently described advantages continuous support childbirth. We were interested opinions MCAs about them having expanded role include emotional childbirth well medical tasks such checking condition...
Despite routine antenatal and postnatal administration of anti-D immunoglobulin (Ig) during pregnancy delivery in a previous pregnancy, 0.1% to 0.3% women are found have Rhesus D (RhD) antibodies their next pregnancy. The primary aim this case-control study was identify causative risk factors for rhesus immunization the among who had received adequate prophylaxis A second evaluate preventive effect additional Ig such with factors. Data obtained from nationwide Dutch anti- D-prophylaxis...