A5049525948- Blood groups and transfusion
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Prenatal Screening and Diagnostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Parvovirus B19 Infection Studies
- Alzheimer's disease research and treatments
- Neonatal Health and Biochemistry
- Tryptophan and brain disorders
- Platelet Disorders and Treatments
- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Gestational Diabetes Research and Management
- Adolescent and Pediatric Healthcare
- Blood transfusion and management
- Blood donation and transfusion practices
- Bone health and treatments
- Sexual Differentiation and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Clinical Laboratory Practices and Quality Control
- Systemic Lupus Erythematosus Research
- Fetal and Pediatric Neurological Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Assisted Reproductive Technology and Twin Pregnancy
- Groundwater and Watershed Analysis
Hôpital Saint-Antoine
2016-2025
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2010-2025
Centre de Recherche Saint-Antoine
2011-2023
Inserm
2009-2023
Hôpital Armand-Trousseau
2021
Expression Génétique Microbienne
2021
Institut de Génomique Fonctionnelle
2017
Hôpitaux Universitaires Paris-Ouest
2013-2015
Hôpital Tenon
2010-2011
Recent studies highlight the implication of innate and adaptive immunity in pathophysiology Alzheimer's disease, foster immunotherapy as a promising strategy for its treatment. Vaccines targeting amyloid-β peptide provided encouraging results mouse models, but severe side effects attributed to T cell responses first clinical trial AN1792 underlined need better understanding disease. We previously showed that regulatory cells critically control amyloid-β-specific CD4 + both physiological...
Increasing evidence supports a key role for peripheral immune processes in the pathophysiology of Alzheimer's disease (AD), highlighting an intricate interplay between brain resident glial cells and both innate adaptive effectors. We previously showed that regulatory T (Tregs) have beneficial impact on progression AD-like pathology, notably by modulating microglial response associated with Aβ deposits mouse model amyloid pathology. Besides microglia, reactive astrocytes also play critical...
Frequency and titers of autoantibodies in patients with sickle-cell disease (SCD) have been reported as relatively high. In a prospective study 88 patients, we examined this "hyper-autoreactivity" its clinical consequences.For 1 year, SCD were screened for the presence their serum antinuclear, anti-double-stranded DNA, antiextractible nuclear antigens, anticardiolipin antibodies, rheumatoid factors. A population 85 sex-matched individuals similar ethnic origin served controls.Whereas...
Background. An in vitro basophil activation test, based on the detection of CD63 upregulation induced by NSAIDs, has been described. Its clinical significance remains controversial. Objectives. In patients with a history nonallergic NSAID hypersensitivity, stratified according to severity symptoms, assess NSAIDs predictive value (BAT) and monocyte (MAT) tests. Patients/Methods. Sixty who had NSAIDs-induced or exacerbated urticaria/angiooedema 20 controls was included. After incubation...
Many RhD variants associated with anti-D formation (partial D) in carriers exposed to the conventional D antigen carry mutations affecting extracellular loop residues. Surprisingly, some transmembrane or intracellular domains, positions not thought likely have a major impact on epitopes.A wild-type Rh trimer (RhD1 RhAG2 ) was modeled by comparative modeling human RhCG structure. Taking conformation, residue accessibility, and position relative lipid bilayer into account, we redefine domains...
Accumulation of amyloid-β peptide (Aβ) is considered the triggering factor pathogenic lesions in Alzheimer's disease (AD), and vaccines targeting Aβ are promising therapeutic options. However, occurrence meningoencephalitides attributed to T cell responses 6% Aβ-immunized patients underscores need for a better understanding Aβ. We characterized parameters controlling magnitude Aβ-specific CD4(+) mice. responsiveness Aβ1-42 was highly heterogeneous between mouse strains different H-2...
Kidney involvement with immunoglobulin crystals usually relates to a light chain of the kappa type, in MGUS or smoldering myeloma, frequently causing Fanconi's syndrome progressive renal insufficiency. We report on case severe myeloma featuring lambda chain-derived and acute kidney injury. Histology showed tubular necrosis tubule obstruction crystals, which were also abundant inside epithelial cells, macrophages bone marrow plasma cells. The variable domain had normal overall primary...
Background and Objectives In Europe, postnatal subsequently antenatal administration of anti‐RH1 (D) immunoglobulins (Ig) has reduced the number maternal immunizations incidence haemolytic disease foetus newborn since 1960s. Non‐invasive foetal RHD genotyping now enables prophylaxis to be targeted only women carrying ‐positive foetus. We aimed at describing how Rh prevention is currently managed in different European countries. Materials Methods prepared an online survey on guidelines...
BACKGROUND In addition to titration by indirect antiglobulin test most widely used, anti‐D quantitation continuous‐flow analysis (CFA) may be performed assess severity of maternal immunization. Only five studies have reported its added value in the management pregnancies complicated STUDY DESIGN AND METHODS A retrospective study 74 severe anti‐D–immunized was conducted from January 1, 2013, December 31, 2014, Trousseau Hospital Paris (France). Concentration measured and CFA two‐stages method...
Vaccines targeting amyloid-beta (Abeta) peptide represent promising therapeutic options for the treatment of Alzheimer's disease (AD). Active immunization against Abeta has emerged as a potential strategy that can prevent deposition and reverse cognitive decline in murine models. However, an vaccination trial (AN1792) human AD patients was prematurely interrupted due to occurrence meningoencephalitides 6% cases, supposedly related inappropriate activation Abeta-specific T cells. In contrast,...
Anti-c is the third red blood cell antibody responsible for haemolytic disease of foetus and newborn (HDFN) requiring intrauterine transfusion. We aimed to identify risk factors associated with HDFN severe due Rhc maternal-foetal incompatibility.A retrospective cohort study was conducted in Paris surrounding area (France), between 2013 2015. included mothers their children managed by National Reference Centre Perinatal Hemobiology alloimmunization incompatibility antigen (N = 121). bivariate...