A5103251991- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Medical Imaging Techniques and Applications
- Phytochemicals and Antioxidant Activities
- Regulation of Appetite and Obesity
- Ophthalmology and Visual Impairment Studies
- Fungal Biology and Applications
- Phytochemistry and Biological Activities
- Sleep and Wakefulness Research
- Retinopathy of Prematurity Studies
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Cardiac electrophysiology and arrhythmias
Zhejiang University
2023
State Key Laboratory of Medical Neurobiology
2020-2022
Fudan University
2020-2022
Zhongshan Hospital
2020-2021
Tianjin University of Science and Technology
2014
The increasing global prevalence of myopia calls for elaboration the pathogenesis this disease. Here, we show that selective ablation and activation intrinsically photosensitive retinal ganglion cells (ipRGCs) in developing mice induced myopic hyperopic refractive shifts by modulating corneal radius curvature (CRC) axial length (AL) an opposite way. Melanopsin- rod/cone-driven signals ipRGCs were found to influence development affecting AL CRC, respectively. role progression is evidenced...
We show for the first time that neuropeptide orexin modulates pupillary light response, a non-image-forming visual function, in mice of either sex. Intravitreal injection receptor (OXR) antagonist TCS1102 and orexin-A reduced enhanced constriction response to light, respectively. Orexin-A activated OX 1 Rs on M2-type intrinsically photosensitive retinal ganglion cells (M2 cells), caused membrane depolarization these by modulating inward rectifier potassium channels nonselective cation...
Recent evidence suggests that melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), a neuronal class regulating non-image forming (NIF) vision and generally thought to be injury resistant, are dysfunctional in certain neurodegenerative diseases. Although disrupted NIF visual functions have been reported patients animals with diabetes, it remains controversial whether ipRGCs exhibit remodeling during diabetes if so, such is variable among ipRGC subtypes. Here, we...
To further utilize glycosaminoglycan from Urechis unicinctus, the hypoglycemic effect and possible mechanism of on diabetic mice were evaluated. Diabetes was induced in by intraperitoneal injections streptozotocin for 3 consecutive days fed with high-sugar high-lipid fodder. After diabetes confirmed, U. unicinctus investigated mice. Results demonstrated that could significantly decrease blood glucose concentrations, HOMA-IR, AUG, liver MDA content In addition, it enhanced SOD GSH-Px...
Oxytocin, secreted by oxytocin neurons in the hypothalamus, is an endogenous neuropeptide involved modulating multiple sensory information processing pathways, and its roles brain have been associated with prosocial, maternal, feeding-related behaviors. Visual necessary for initiating these behaviors, retina consisting of first stage visual system mediating external stimulus perception. Oxytocin has detected mammalian retina; however, expression possible function receptors (OxtR) remain...
Purpose: Experimental access to specific cell subtypes is essential for deciphering the complexity of retinal networks. Here, we characterized selective labeling, caused by ectopic transgene expression, two atypical neurons in ChAT-Channelrhodopsin-2 (ChR2)-EYFP mouse. Methods: Retinal sections and flat-mounts were prepared double-staining immunohistochemistry with antibodies against EYFP various neuronal markers. Sagittal/coronal brain slices made visualize signals central nuclei....