A5080952866- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Nerve injury and regeneration
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Glycogen Storage Diseases and Myoclonus
- Neurological Disease Mechanisms and Treatments
- Retinoids in leukemia and cellular processes
- Adipose Tissue and Metabolism
- Genetic Neurodegenerative Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Muscle metabolism and nutrition
- Neurobiology of Language and Bilingualism
- Amyotrophic Lateral Sclerosis Research
- RNA Interference and Gene Delivery
The University of Sydney
2021-2024
The University of Melbourne
2014-2016
Austin Health
2016
Muscle glucose storage and muscle glycogen synthase (gys1) defects have been associated with insulin resistance. As there are multiple mechanisms for resistance, the specific role of is not clear. The aim this study was to examine effects muscle-specific gys1 deletion on metabolism exercise capacity. Tamoxifen inducible gys-1 KO mice were generated using Cre/loxP system. Mice subjected tolerance tests, euglycemic/hyperinsulinemic clamps tests. gys1-KO showed ≥85% reduction in mRNA protein...
Abstract Amygdala atrophy has been found in frontotemporal dementia (FTD), yet the specific changes of its subregions across different FTD phenotypes remain unclear. The aim this study was to investigate volumetric alterations amygdala and how they evolve with disease progression. Patients clinically diagnosed behavioral variant (bvFTD) ( n = 20), semantic (SD) primary nonfluent aphasia (PNFA) Alzheimer’s (AD) 20 matched healthy controls underwent whole brain structural MRI. patient groups...
Pseudobulbar affect is a disorder of emotional expression commonly observed in amyotrophic lateral sclerosis (ALS), presenting as episodes involuntary laughter, or crying. The objective the current study was to determine association between frequency pathological laughter and crying (PLC) with clinical features, cognitive impairment, brainstem pathology. Thirty-five sporadic ALS patients underwent neuropsychological assessment, subset also undergoing brain imaging. Center for Neurological...
This study seeks to determine whether knockdown of basal forebrain p75 neurotrophin receptor (p75 NTR ) expression elicits increased hippocampal choline acetyltransferase (ChAT) activity in mature animals. Antisense (AS) oligonucleotides (oligos) targeting were infused into the medial septal area rats continuously for 4 weeks. In all rats, cannula outlet was placed equidistant between left and right sides vertical diagonal band Broca. We tested phosphorothioate (PS), morpholino (Mo), gapmer...
Abstract Background The amygdala is a complex and heavily connected subcortical brain structure. It plays central role in regulating social, emotional cognitive processes. Amygdala atrophy has been previously reported Alzheimer’s disease (AD) frontotemporal dementia (FTD), although the findings are inconsistent. In addition, trajectories of progression over time unclear. aim this study was to determine structural changes early AD FTD map their time. Method Patients clinically diagnosed with...