A5101592325- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Receptor Mechanisms and Signaling
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Cardiac Imaging and Diagnostics
- Retinoids in leukemia and cellular processes
- Cancer Treatment and Pharmacology
- Diabetes Treatment and Management
- Asthma and respiratory diseases
- Cardiovascular Function and Risk Factors
- Dialysis and Renal Disease Management
- Breast Cancer Treatment Studies
- Gastrointestinal disorders and treatments
- Pancreatic function and diabetes
- Cardiac Structural Anomalies and Repair
- Synthesis and Biological Evaluation
- Cardiac Arrhythmias and Treatments
- Neuropeptides and Animal Physiology
- Eosinophilic Disorders and Syndromes
- Glycosylation and Glycoproteins Research
- Inflammatory mediators and NSAID effects
- Mast cells and histamine
- Ion Channels and Receptors
Okayama Red Cross General Hospital
2021-2024
Saitama International Medical Center
2023
Toranomon Hospital
2021
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
2020-2021
Hiroshima City Asa Citizens Hospital
2019-2020
Tokushima Municipal Hospital
2018
Aizawa Hospital
2015-2018
Okayama Medical Center
1998-2017
National Hospital Organization
2005-2017
Osaka International Cancer Institute
1997-2014
A novel therapeutic approach is urgently needed for BCR-ABL-positive acute lymphoblastic leukemia (ALL). In this study, we assessed the efficacy and feasibility of chemotherapy combined with imatinib.A phase II study imatinib-combined was conducted newly diagnosed ALL in adults. Eighty patients were entered into trial between September 2002 January 2005.Remission induction therapy resulted complete remission (CR) 77 (96.2%), resistant disease one patient, early death two patients, as well...
In the course of continuing efforts to develop potent and bladder-selective muscarinic M3 receptor antagonists, quinuclidin-3-yl 1-aryl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives related compounds were designed as conformationally restricted analogues benzhydrylcarbamate (8). Binding assays with rat subtypes revealed that showed high affinities for receptor, selectivity over M2 receptor. Of these derivatives, (+)-(1S,3'R)-quinuclidin-3'-yl...
Summary The clinical significance of minimal residual disease (MRD) is uncertain in patients with Philadelphia chromosome‐positive acute lymphoblastic leukaemia (Ph+ ALL) treated imatinib‐combined chemotherapy. Here we report the results prospective MRD monitoring 100 adult patients. Three hundred and sixty‐seven follow‐up bone marrow samples, collected at predefined time points during a uniform treatment protocol, were analysed for BCR‐ABL1 transcripts by quantitative reverse transcription...
A short, efficient, and stereocontrolled synthesis of (−)-4, an advanced ABCD subunit the spongistatins, has been achieved. Central to synthetic strategy is multicomponent linchpin union silyl dithianes with epoxides access both AB CD fragments. Fragment coupling was then achieved via efficient stereoselective aldol reaction. The linear sequence required 22 steps proceeded in 4.0% overall yield.
D-Amino acid oxidase (DAAO) catalyzes the oxidation of d-amino acids including d-serine, a coagonist N-methyl-d-aspartate receptor. We identified series 4-hydroxypyridazin-3(2H)-one derivatives as novel DAAO inhibitors with high potency and substantial cell permeability using fragment-based drug design. Comparisons complex structures deposited in Protein Data Bank well those determined in-house fragment hits revealed that hydrophobic subpocket was formed perpendicular to flavin ring by...
Apparently non-porous activated carbon with a specific surface area less than 100 m2/g(BET) prepared from calcined of petroleum coke is studied as the polarized electrode for an Electric Double Layer Capacitor(EDLC). The makes negligibly small electric double layer when it dipped into electrolyte solution in beginning. During initial charging process, however, "solvent co-intercalation ions" builds layers positive and negative electrodes, during discharging excess ions go out, while opposite...
Background: Trastuzumab deruxtecan is classified as an anticancer agent that poses a moderate emetic risk in the international guidelines for antiemetic therapy.The recommend emesis prophylaxis using two-drug combination therapy comprising 5-hydroxytryptamine-3 receptor antagonist (5-HT3RA) and dexamethasone (DEX).However, high incidence of nausea vomiting associated with trastuzumab problematic.The National Comprehensive Cancer Network guideline version 1.2023 having changed its...
We describe a 56-year-old woman with histiocytic sarcoma involving the bone marrow. The neoplastic cells proliferated diffusely and showed occasional erythrophagocytosis. Immunohistochemically, were positive for CD68, lysozyme, CD4 CD163, but negative B- T-cell markers, S100 protein epithelial markers. patient received multi-agent chemotherapy is living at 22 months after diagnosis without recurrence. Histiocytic an exceedingly rare hematopoietic neoplasm prognosis poor due to its rapid...
To examine the characteristic features of risk factors for macroangiopathy (MA) in nonobese Japanese NIDDM patients, 899 patients with and without MA were registered from 40 facilities. Of these, 386 subjects identified as having any form (total MA); these included 211 ischemie heart disease (IHD), 163 cerebrovascular (CVD), 77 peripheral vascular (PVD). Univariate analyses revealed following common total MA, IHD, CVD, PVD: age, hypertension, systolic blood pressure (sBP) or diastolic (dBP),...