A5037298485- Amyloidosis: Diagnosis, Treatment, Outcomes
- Alzheimer's disease research and treatments
- Peroxisome Proliferator-Activated Receptors
- Commutative Algebra and Its Applications
- Endoplasmic Reticulum Stress and Disease
- Algebraic structures and combinatorial models
- Drug Transport and Resistance Mechanisms
- Porphyrin Metabolism and Disorders
- Heat shock proteins research
- Homotopy and Cohomology in Algebraic Topology
- Dermatological and Skeletal Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Prion Diseases and Protein Misfolding
- Remote-Sensing Image Classification
- Lipid metabolism and disorders
- Chronic Kidney Disease and Diabetes
- Connexins and lens biology
- RNA regulation and disease
- Pharmacological Effects of Natural Compounds
- Coenzyme Q10 studies and effects
- Hair Growth and Disorders
- Maritime and Coastal Archaeology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Customer churn and segmentation
Shinshu University
2014-2024
The University of Kitakyushu
2017
Kanazawa University
2015
Oxidative damage in endothelial cells is proposed to play an important role dysfunction and atherogenesis. We previously reported that the reduced form of coenzyme Q10 (CoQ10H2) effectively inhibits oxidative stress decelerates senescence senescence-accelerated mice. Here, we treated human umbilical vein (HUVECs) with H2O2 investigated protective effect CoQ10H2 against senescence, damage, reduction cellular functions. found markedly number senescence-associated β-galactosidase-positive...
During acute-phase response (APR), there is a dramatic increase in serum amyloid A (SAA) plasma high density lipoproteins (HDL). Elevated SAA leads to reactive AA amyloidosis animals and humans. Herein, we employed apolipoprotein A-II (ApoA-II) deficient (Apoa2 -/- ) transgenic (Apoa2Tg) mice investigate the potential roles of ApoA-II lipoprotein particle formation progression during APR. deposition was suppressed Apoa2 compared with wild type (WT) mice. APR, exhibited significant...
Curcumin is a polyphenol compound that exhibits multiple physiological activities. To elucidate the mechanisms by which curcumin affects systemic amyloidosis, we investigated amyloid deposition and molecular changes in mouse model of apolipoprotein A-II (AApoAII) mice were fed curcumin-supplemented diet. supplementation for 12 weeks significantly increased AApoAII relative to controls, especially liver spleen. Liver weights plasma ApoA-II high-density lipoprotein concentrations elevated...
In mouse senile amyloidosis, apolipoprotein (Apo) A-II is deposited extracellularly in many organs the form of amyloid fibrils (AApoAII). Reduction caloric intake, known as restriction (CR), slows progress senescence and age-related disorders mice. this study, we intravenously injected 1 μg isolated AApoAII into R1.P1-Apoa2c mice to induce experimental amyloidosis investigated effects CR for next 16 weeks. group, deposits liver, tongue, small intestine skin were significantly reduced...
Mouse senile amyloidosis is a disorder in which apolipoprotein A-II deposits extracellularly many organs as amyloid fibrils (AApoAII). In this study, we intravenously injected 1 μg of isolated AApoAII into R1.P1-Apoa2(c) mice, to induce amyloidosis. We observed that the unfolded protein response was induced by deposition amyloid. found mRNA and expression levels heat shock A5 (HSPA5; also known glucose-regulated 78) were increased liver with deposits. Immunohistochemistry showed HSPA5 only...
ABSTRACT Exercise interventions are beneficial for reducing the risk of age-related diseases, including amyloidosis, but underlying molecular links remain unclear. Here, we investigated protective role interval exercise training in a mouse model systemic apolipoprotein A-II amyloidosis (AApoAII) and identified potential mechanisms. Mice subjected to 16 weeks showed improved whole-body physiologic functions exhibited substantial inhibition particularly liver spleen. activated hepatic p38...
Amyloidosis is a group of diseases characterized by protein misfolding and aggregation to form amyloid fibrils subsequent deposition within various tissues. Previous studies have indicated that amyloidosis often associated with oxidative stress. However, it not clear whether stress involved in the progression amyloidosis. We administered inhibitors tempol apocynin via drinking water R1.P1-Apoa2c mouse strain induced develop apolipoprotein A-II (AApoAII) found treatment led reduction AApoAII...
Glavonoid-rich oil (GRO) derived from ethanol extraction of licorice (Glycyrrhiza glabra Linne) root has been reported to have beneficial effects on health. In this study, we aimed determine the effect long-term administration GRO metabolic disorders and elucidate molecular mechanism. Female obese, type 2 diabetic KK-Ay mice were fed diets supplemented with 0.3% or 0.8% (w/w) for 4–12 weeks. Mice euthanized autopsied at 20 weeks old. The lipid glucose metabolism evaluated by measuring...
Mouse senile amyloidosis is a disorder in which apolipoprotein A-II (APOA2) deposits as amyloid fibrils (AApoAII) many organs. We previously reported that AApoAII can be transmitted by feces, milk, saliva and muscle originating from mice with deposition. In this study, the ability of blood components to transmit was evaluated our model system. Blood samples were collected SAMR1.SAMP1-Apoa2c amyloid-laden or amyloidosis-negative mice. The fractionated into plasma, white cell (WBC) red (RBC)...
Amyloid resistance is the inability or reduced susceptibility of an organism to develop amyloidosis. In this study we have analysed molecular basis systemic AApoAII amyloidosis, which arises from formation amyloid fibrils apolipoprotein A-II (ApoA-II). The disease affects humans and animals, including SAMR1C mice that express C allele ApoA-II protein, whereas other mouse strains are resistant development amyloidosis due expression alleles, such as ApoA-IIF. Using cryo-electron microscopy,...
Mammalian CpG islands (CGIs) normally escape DNA methylation in all adult tissues and developmental stages. However, our previous study we unexpectedly identified many methylated CGIs human peripheral blood leukocytes. Methylated dinucleotides convert to TpG through deaminization of their cytosine bases more frequently than hypomethylated dinucleotides. Therefore, wondered how germline or non-germline cells maintain CpG-rich sequences. It is known that events such as hypomethylation,...
Customer momentum has been demonstrated to be effective in the US and Japanese stock markets but not examined using a large global supply chain network. In this article, authors propose new customer strategy based on network data combined with prior research. They apply (1) theory, (2) medium-term propagation, (3) higher-layer information characteristics of data. Empirical analysis confirms that proposed 4.5% annual return long–short analysis. This is more than standard former studies....
During the acute-phase response (APR), there is a dramatic increase in serum amyloid A (SAA) circulating blood high-density lipoproteins (HDL). Free SAAs dissociate from HDL aggregates to...
We study Gorenstein dimension and grade of a module M over filtered ring whose associated graded is commutative Noetherian ring. An equality or an inequality between these invariants its the most valuable property for investigation rings. prove G−dim ≤ gr = M, whenever finite (Theorems 2.3 2.8). would say that use G-dimension adds new viewpoint studying rings modules. apply results to with Cohen–Macaulay Cohen–Macaulay, perfect, holonomic module.
Amyloidosis refers to a group of degenerative diseases that are characterized by the deposition misfolded protein fibrils in various organs. Deposited amyloid may be removed phagocyte-dependent innate immune system; however, precise mechanisms during disease progression remain unclear. We herein investigated properties macrophages contribute degradation and using inducible apolipoprotein A-II amyloidosis model mice. Intravenously injected AApoAII was efficiently engulfed reticuloendothelial...
In humans, mutations in the coproporphyrinogen oxidase (CPOX) gene can result hereditary coproporphyria (HCP), characterized by high levels of coproporphyrin excretion urine and feces, as well acute neurovisceral chronic cutaneous manifestations. Appropriate animal models for comprehending precise pathogenesis mechanism HCP have not been reported that show similarities terms mutation, reduced CPOX activity, excess accumulation, clinical symptoms. As previously discovered, BALB.NCT-Cpoxnct...