A5087111955- Cancer, Hypoxia, and Metabolism
- Virus-based gene therapy research
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- PI3K/AKT/mTOR signaling in cancer
- Ferroptosis and cancer prognosis
- Clusterin in disease pathology
- Cancer Research and Treatments
- interferon and immune responses
- Biomarkers in Disease Mechanisms
- Advanced biosensing and bioanalysis techniques
- Telomeres, Telomerase, and Senescence
- Metabolism, Diabetes, and Cancer
- MicroRNA in disease regulation
Heidelberg University
2017-2023
German Cancer Research Center
2017-2023
A temporal systems biology screen of premetastatic endothelial cells identified LRG1 as a therapeutic target for restricting metastases.
Oncogenic HPV types are major human carcinogens. Under hypoxia, HPV-positive cancer cells can repress the viral E6/E7 oncogenes and induce a reversible growth arrest. This response could contribute to therapy resistance, immune evasion, tumor recurrence upon reoxygenation. Here, we uncover evidence that oncogene repression is mediated by hypoxia-induced activation of canonical PI3K/mTORC2/AKT signaling. AKT-dependent downregulation only observed under hypoxia occurs, at least in part,...
Abstract Oncogenic types of human papillomaviruses (HPVs) are major carcinogens. The viral E6/E7 oncogenes maintain the malignant growth HPV‐positive cancer cells. Targeted inhibition results in efficient induction cellular senescence, which could be exploited for therapeutic purposes. Here we show that expression is strongly downregulated by Metformin cervical and head neck cells, both at transcript protein level. Metformin‐induced repression glucose PI3K‐dependent but—other than under...
The iron-chelating drug ciclopirox (CPX) may possess therapeutic potential for cancer treatment, including cervical cancer. As is observed other chemotherapeutic drugs, CPX can induce senescence or apoptosis in cells which could differently affect their therapy response. present study aims to gain insights into the determinants govern switch between and cells. We performed proteome analyses, proliferation studies by live-cell imaging colony formation assays, combination treatments of with...
Abstract Cycling hypoxia (cycH) is a prevalent form of tumor that characterized by exposure cells to recurrent phases and reoxygenation. CycH has been associated with particularly aggressive cellular phenotype increased therapy resistance. By performing comparative analyses under normoxia, physoxia, chronic hypoxia, cycH, we here uncover distinct effects cycH on the human papillomavirus (HPV)‐positive cervical cancer cells. We show that—other than hypoxia—viral E6/E7 oncogene expression...