A5050110993- Angiogenesis and VEGF in Cancer
- Infective Endocarditis Diagnosis and Management
- Actinomycetales infections and treatment
- Congenital heart defects research
- Neurogenesis and neuroplasticity mechanisms
- Connexins and lens biology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Barrier Structure and Function Studies
- Heart Failure Treatment and Management
- Zebrafish Biomedical Research Applications
- Vascular Malformations and Hemangiomas
- Cancer Genomics and Diagnostics
- Transplantation: Methods and Outcomes
- Wnt/β-catenin signaling in development and cancer
- Vascular Anomalies and Treatments
- Acute Myeloid Leukemia Research
- Cerebrovascular and genetic disorders
Medical University of South Carolina
2024-2025
University of Virginia
2020-2023
Kansai Medical University
2023
Abstract During blood vessel development, endothelial cells become specified toward arterial or venous fates to generate a circulatory network that provides nutrients and oxygen to, removes metabolic waste from, all tissues. Arterial-venous specification occurs in conjunction with suppression of cell cycle progression; however, the mechanistic role state is unknown. Herein, using Cdh5-CreER T2 ;R26FUCCI2aR reporter mice, we find are enriched for FUCCI-Negative (early G1) BMP signaling, while...
Clonal hematopoiesis (CH), which results from an array of nonmalignant driver gene mutations, can lead to altered immune cell function and chronic disease, has been associated with worse outcomes in patients heart failure (HF) reduced ejection fraction. However, the role CH prognosis HF preserved fraction (HFpEF) understudied. This study aimed characterize HFpEF elucidate its causal a murine model.
The subventricular zone (SVZ) is the largest neural stem cell (NSC) niche in adult brain; herein, blood-brain barrier leaky, allowing direct interactions between NSCs and endothelial cells (ECs). Mechanisms by which NSC-EC SVZ control NSC behavior are unclear. We found that Cx43 highly expressed ECs, its deletion either leads to increased proliferation neuroblast generation, suggesting Cx43-mediated maintain quiescence. This further supported single-cell RNA sequencing vitro studies showing...
Distinct endothelial cell cycle states (early G1 versus late G1) provide different "windows of opportunity" to enable the differential expression genes that regulate venous arterial specification, respectively. Endothelial control and arteriovenous identities are disrupted in vascular malformations including shunts, hallmark hereditary hemorrhagic telangiectasia (HHT). To date, mechanistic link between regulation development (AVMs) HHT is not known.
Summary Formation and maturation of a functional blood vascular system is required for the development maintenance all tissues in body. During process vessel development, primordial endothelial cells are formed become specified toward arterial or venous fates to generate circulatory network that provides nutrients oxygen to, removes metabolic waste from, 1-3 . Specification occurs conjunction with suppression cell cycle progression 4,5 , hyperproliferation associated potentially lethal...
e24002 Background: Non-bacterial thrombotic endocarditis (NBTE) is a condition in which sterile vegetations are deposited on the cardiac valves, disrupting their function, and posing risk for embolic stroke. It rare with rates autopsy studies ranging from 0.9-1.6%1, some of highest observed patients pancreatic cancer (PC).2 A review PC-associated NBTE was conducted to improve our understanding recognition this but serious clinical entity. Methods: We performed literature search PubMed...
Abstract The subventricular zone (SVZ) is the largest neural stem cell (NSC) niche in adult brain; herein, blood-brain barrier leaky, allowing direct interactions between NSCs and endothelial cells (ECs). Mechanisms by which NSC-EC SVZ control NSC behavior are unclear. We found Cx43 to be highly expressed both ECs SVZ, its deletion either type leads increased proliferation neuroblast generation, suggesting that Cx43-mediated maintain quiescence. This further supported vitro studies showing...