<h3>BACKGROUND AND PURPOSE:</h3> Pathological changes in the intracranial aneurysm wall may lead to increases its permeability; however clinical significance of such has not been explored. The purpose this pilot study was quantify permeability (<i>K</i>^trans, V_L) contrast agent as a measure rupture risk and compare these parameters against other established measures risk. We hypothesized <i>K</i>^trans would be associated with defined by various anatomic,...

The role of gray matter in multiple sclerosis is increasingly evident; however, conventional images demonstrate limitations cortical lesion identification. Perfusion imaging appears sensitive to changes tissue type and disease severity MS. We sought use bookend perfusion quantify parameters healthy controls normal-appearing lesional at different relapsing-remitting MS stages.Thirty-nine patients with 19 age-matched were prospectively recruited. Minimal Assessment Cognitive Function battery...

Background: Cognitive impairment affects 40%–68% of relapsing-remitting multiple sclerosis (RRMS) patients. Gray matter (GM) demyelination is complicit in cognitive impairment, yet cortical lesions are challenging to image clinically. We wanted determine whether cerebral blood flow (CBF), volume (CBV), and mean transit time (MTT) differences exist between cognitively impaired (CI) unimpaired (NI) RRMS. Methods: Prospective study healthy controls ( n = 19), CI 20), NI 19) undergoing magnetic...

Purpose: Detection of cortical abnormalities in relapsing-remitting multiple sclerosis (RRMS) remains elusive. Structural magnetic resonance imaging (MRI) measures integrity are limited, although functional techniques such as pseudo-continuous arterial spin labeling (pCASL) show promise a surrogate marker disease severity. We sought to determine the utility pCASL assess cerebral blood flow (CBF) RRMS patients with (RRMS-I) and without (RRMS-NI) cognitive impairment. Methods: A total 19...

Cortical dysfunction, quantifiable by cerebral perfusion techniques, is prevalent in patients with MS, contributing to cognitive impairment. We sought localize distribution differences relapsing-remitting MS and without impairment healthy controls.Thirty-nine (20 cognitively impaired, 19 nonimpaired) age- sex-matched controls underwent a neurocognitive battery MR imaging. Voxel-based analysis compared regional deep cortical GM volume among the cohorts.After we adjusted for localized...

Case Reports1 July 1959PRIMARY IDIOPATHIC MYOGLOBINURIA IN A NEGRO FEMALE: ITS IMPLICATIONS AND NEW METHOD OF LABORATORY DIAGNOSISC. L. WHISNANT JR., M.D., R. H. OWINGS, M.S., C. G. CANTRELL, COOPER, Ph.D., M.D.C. M.D.Search for more papers by this author, M.S.Search authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-1-140 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail...

Intracranial atherosclerotic disease plaque hyperintensity and/or gadolinium contrast enhancement have been studied as imaging biomarkers of acutely symptomatic ischemic presentations using single static MR measurements. However, the value in modeling dynamics intracranial permeability has yet to be evaluated. The purpose this study was use dynamic contrast-enhanced quantify plaques patients and compare these parameters against existing markers volatility black-blood pulse sequences.We...

Purpose This work sought to compare a quantitative T 1 bookend dynamic susceptibility contrast MRI based perfusion protocol for absolute cerebral blood flow (qCBF) against CBF measured by the stable‐isotope neutron capture microsphere method, recognized reference standard measuring tissue flow, at normocapnia, hypercapnia, and in acute stroke. Methods was anesthetized female canines microspheres over 2 consecutive days each case. On day 1, 5 were before during physiological challenge induced...

Treatment of viral infections with combinations antiviral agents may permit administration reduced doses either or both drugs. Lowered reduce associated toxicity. Intravenous substantial human recombinant β interferon (rHuIFN-β) 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) prevents development simian varicella virus infection in African green monkeys. Daily 2 × 106 U rHuIFN-β/kg inhibited clinical disease monkeys inoculated virus, and DHPG between 20 60 mg/kg per day were necessary for...

Recent studies utilizing perfusion as a surrogate of cortical integrity show promise for overall cognition, but the association between white matter (WM) damage and gray (GM) in specific functional networks is not previously studied.To investigate relationship WM fiber GM node within six relapsing-remitting multiple sclerosis (RRMS) secondary progressive (SPMS) patients.Magnetic resonance imaging (MRI) neurocognitive testing were performed on 19 healthy controls (HC), 39 RRMS, 45 SPMS...

Purpose The purpose of this study was to investigate the diffusional transport contrast agent and its effects on kinetic modeling dynamic enhanced (DCE) images. Methods We performed simulations our diffusion‐compensated model compared these results human intracranial aneurysms (IAs). derive an easy‐to‐use parameterization that can provide accurate estimate diffusion corrected leakage rates (k trans ). Finally, we re‐ansalysis existing data set determine whether diffusion‐corrected parameters...

<h3>BACKGROUND AND PURPOSE:</h3> The spatial correlation between WM and cortical GM disease in multiple sclerosis is controversial has not been previously assessed with perfusion MR imaging. We sought to determine the nature of association lobar WM, GM, volume perfusion. <h3>MATERIALS METHODS:</h3> Nineteen individuals secondary-progressive sclerosis, 19 relapsing-remitting age-matched healthy controls were recruited. Quantitative imaging was used derive CBF, CBV, MTT within T2-hyperintense...

<h3>BACKGROUND AND PURPOSE:</h3> Quantitative CBF usage as a biomarker for cognitive impairment and disease progression in MS is potentially powerful tool longitudinal patient monitoring. Dynamic susceptibility contrast perfusion with bookend T1-calibration (bookend technique) pseudocontinuous arterial spin-labeling have recently been used quantification relapsing-remitting MS. The noninvasive nature of advantageous over gadolinium-based techniques, but correlation between the techniques not...

Magnetic resonance (MR)-based oxygen extraction fraction (OEF) measurement techniques that use blood level-dependent (BOLD)-based approaches require the of R 2 ′ decay rate and deoxygenated volume to derive local saturation in vivo. We describe here a novel approach measure OEF using rapid frequency mapping. By modeling MR process static dephasing regime as two separate dissipative oscillatory effects, we calculate from frequencies measured across brain by assuming biophysical mechanisms...

To introduce a pair of accelerated non-Cartesian acquisition principles that when combined, exploit the periodicity k-space acquisition, and thereby enable high-temporal cine Cardiac Magnetic Resonance (CMR).The mathematical formulation noniterative, undersampled reconstruction is presented. First, low-pass filtering step exploits streaking artifact redundancy provided (i.e., Dynamically Interleaved Streak removal in Power-spectrum Encoded domain with Low-pass [DISPEL]). Next, an effective...

Haemograms were determined for 90 Mystromys, 3-24 months of age, to establish normal values and evaluate the influence age gender. Males over 6 had higher red blood cell counts, packed volumes haemoglobin levels than females same age. The haemograms 3-5 old resembled those males. Age gender did not cause detectable differences in leucocyte numbers animals old.

Introduction: Asymmetric hemispheric cerebral Oxygen Extraction Fraction (OEF) has been shown to be an independent predictor of stroke risk. Furthermore, the NIH/NINDS Progress Review Group recently named tissue oxygenation imaging as a primary research goal in its August 2013 review. We have developed novel method OEF with MRI. present analysis MR-OEF images using breath-hold and cardiac-gating inducers physiologic stress. Methods: acquire 2D k-space volume rosette trajectory 65 ms for...

We report a novel application of an MRI technique called Parameter Assessment by Retrieval from Signal Encoding (PARSE) to measure OEF. OEF is crucial importance, providing information about the stage neurovascular impairment in patient and risk stroke such patient. In this study, we test hypothesis that PARSE can be used oxygen extraction brain. This method uses more accurate MR signal model, employs non-Cartesian Rosette trajectory encode multiple parameters simultaneously estimate M 0 , R...