A5061747366- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Photoacoustic and Ultrasonic Imaging
- Meningioma and schwannoma management
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Optical Imaging and Spectroscopy Techniques
- Atomic and Subatomic Physics Research
- Peripheral Artery Disease Management
- Infectious Diseases and Tuberculosis
- Virus-based gene therapy research
- Bone Tumor Diagnosis and Treatments
- Ultrasound and Hyperthermia Applications
- Functional Brain Connectivity Studies
- Cerebral Venous Sinus Thrombosis
- Venous Thromboembolism Diagnosis and Management
- Neurofibromatosis and Schwannoma Cases
University of Chicago
2014-2024
Mount Carmel Health
2021-2024
Icahn School of Medicine at Mount Sinai
2024
University of Illinois Chicago
2024
University of Chicago Medical Center
2010-2023
University of Utah
2018
National Institute of Neurological Disorders and Stroke
2018
Mayo Clinic
2018
Johns Hopkins University
2018
Angioma Alliance
2018
The tumor microenvironment is being increasingly recognized as an important determinant of progression well therapeutic response. We investigated oncolytic virus (OV) therapy-induced changes in blood vessels and the impact modulating vasculature on efficacy therapy.Rat glioma cells (D74/HveC) were implanted intracranially immune-competent rats. Seven days later, rats (groups 3-7 rats) treated with (hrR3), and, 3 brains harvested for evaluation. Some angiostatic cRGD peptide 4 before...
Abstract Purpose: The purpose of the present study was to evaluate anti–epidermal growth factor monoclonal antibody (mAb) cetuximab (IMC-C225) as a delivery agent for boron neutron capture therapy (BNCT) human epidermal receptor (EGFR) gene-transfected rat glioma, designated F98EGFR. Experimental Design: A heavily boronated polyamidoamine dendrimer chemically linked by means heterobifunctional reagents N-succinimidyl 3-(2-pyridyldithio)-propionate and N-(k-maleimido undecanoic...
Abstract BACKGROUND More than a million Americans harbor cerebral cavernous angioma (CA), and those who suffer prior symptomatic hemorrhage have an exceptionally high rebleeding risk. Preclinical studies show that atorvastatin blunts CA lesion development through inhibiting RhoA kinase (ROCK), suggesting it may confer therapeutic benefit. OBJECTIVE To evaluate whether produces difference compared to placebo in lesional iron deposition as assessed by quantitative susceptibility mapping (QSM)...
Patients with the familial form of cerebral cavernous malformations (CCMs) are haploinsufficient for CCM1, CCM2, or CCM3 gene. Loss corresponding CCM proteins increases RhoA kinase-mediated endothelial permeability in vitro, and mouse brains vivo. A prospective case-controlled observational study investigated whether human subjects show vascular hyperpermeability by dynamic contrast-enhanced quantitative perfusion magnetic resonance imaging, comparison cases without disease, lesional brain...
Hyperpermeability and iron deposition are 2 central pathophysiological phenomena in human cerebral cavernous malformation (CCM) disease. Here, we used novel MRI techniques to establish a relationship between these phenomena.Subjects with CCM disease (4 sporadic 17 familial) underwent imaging using the dynamic contrast-enhanced quantitative perfusion susceptibility mapping that measure hemodynamic factors of vessel leak deposition, respectively, previously demonstrated Regions interest...
OBJECTIVE Vascular permeability and iron leakage are central features of cerebral cavernous malformation (CCM) pathogenesis. The authors aimed to correlate prospective clinical behavior CCM lesions with longitudinal changes in biomarkers dynamic contrast-enhanced quantitative (DCEQP) susceptibility mapping (QSM) assessed by MRI. METHODS Forty-six patients CCMs underwent 2 or more and/or studies conjunction baseline follow-up imaging surveillance during a mean 12.05 months (range 2.4-31.27...
The purpose of this work was to describe the deep vascular anatomy human brain using high resolution MR gradient echo imaging at 8 T.Gradient images were acquired from head a transverse electromagnetic resonator operating in quadrature and tuned 340 MHz. Typical acquisition parameters as follows: matrix = 1,024 x 1,024, flip angle 45 degrees, TR 750 ms, TE 17 FOV 20 cm, slice thickness 2 mm. This resulted an in-plane approximately 200 microm. Images analyzed, structures identified on basis...
Cerebral infarction evolves at different rates depending on available blood flow suggesting that treatment time windows vary the degree of pial collateral recruitment. This work sought to mathematically model infarct growth and determine whether volume can be predicted by angiographic assessment recruitment in an experimental MCA occlusion animal model.Pial was quantified using DSA, acquired 15 minutes following permanent 6 canines based a scoring system (average score) arterial arrival...
Objectives: This work aimed to refine a large animal in minimally invasive reversible middle cerebral artery (MCA) occlusion (MCAO) model account for leptomeningeal collateral formation. Materials and Methods: An angiographically based methodology allowed transient MCA carotid terminus 12 mongrel dogs assessment of pial recruitment. Outcome measures included 1- 24-hour magnetic resonance imaging-based infarct volume calculation, behavioral scale histopathologic sections. Results: MCAO...
Quantitative susceptibility mapping has been shown to assess iron content in cerebral cavernous malformations. In this study, our aim was correlate lesional deposition assessed by quantitative with clinical and disease features patients malformations.Patients underwent routine scans addition on 3T systems. Data from 105 met the inclusion criteria. Cerebral malformation lesions identified maps were cross-verified T2-weighted images differentiated basis of prior overt hemorrhage. Mean per...
Cerebral cavernous angioma (CA) is a capillary microangiopathy predisposing more than million Americans to premature risk of brain hemorrhage. CA with recent symptomatic hemorrhage (SH), most likely re-bleed serious clinical sequelae, the primary focus therapeutic development. Signaling aberrations in include proliferative dysangiogenesis, blood-brain barrier hyperpermeability, inflammatory/immune processes, and anticoagulant vascular domain. Plasma levels molecules reflecting these...
Abstract We studied two 16‐year‐old males with juvenile muscular atrophy of the distal arm, “Hirayama disease,” resulting in asymmetric and weakness upper extremities. Pathogenic theories include a compressive myelopathy or without ischemia, occasional cases are accounted for by genetic mutations. To specifically address ischemia hypothesis we performed spinal angiography epidural venography. Neck flexion during showed forward shift nonoccluded anterior artery impedance to blood flow....
Background Quantitative Susceptibility Mapping (QSM) MRI allows accurate assessment of iron content in cerebral cavernous malformations (CCM), and a threshold increase by 6% QSM has been shown to reflect new symptomatic hemorrhage (SH) previously stable lesions. Purpose/Hypothesis It is unclear how lesional evolves CCMs after recent SH, whether this could serve as monitoring biomarker clinical trials aimed at preventing rebleeding these Study Type This prospective observational cohort study....
Purpose: High resolution MR images obtained from a normal human volunteer at 8 T are utilized to describe the appearance of iron-containing deep gray nuclei this field strength. Method: (1,024 × 1,024 matrix) near-axial gradient echo were acquired on by using an scanner. The transverse electromagnetic resonator operating in quadrature. following parameters utilized: TR = 750 ms, TE 17 flip angle 45°, receiver bandwidth 50 kHz, slice thickness 2 mm, FOV 20 cm. reviewed and correlated known...