A5035562150- Natural Antidiabetic Agents Studies
- Advanced Glycation End Products research
- Protein Interaction Studies and Fluorescence Analysis
- Vitamin C and Antioxidants Research
- Vitamin D Research Studies
- Biochemical effects in animals
- Photodynamic Therapy Research Studies
- Trace Elements in Health
- Free Radicals and Antioxidants
- Drug Transport and Resistance Mechanisms
- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Carcinogens and Genotoxicity Assessment
- Computational Drug Discovery Methods
- Chemotherapy-induced organ toxicity mitigation
- Metal complexes synthesis and properties
- Nanoplatforms for cancer theranostics
- Heavy Metal Exposure and Toxicity
- Genomics, phytochemicals, and oxidative stress
- Diet and metabolism studies
- Moringa oleifera research and applications
- Hemoglobin structure and function
- Retinoids in leukemia and cellular processes
- Phytoestrogen effects and research
- Heme Oxygenase-1 and Carbon Monoxide
Aligarh Muslim University
2014-2023
Riboflavin (RF) plays an important role in various metabolic redox reactions the form of flavin adenine dinucleotide and mononucleotide. Human serum albumin (HSA) is protein involved transportation drugs, hormones, fatty acid other molecules which determine biodistribution physiological fate these molecules. In this study, we have investigated interaction riboflavin RF with HSA under simulative conditions using biophysical, calorimetric molecular docking techniques. Results demonstrate...
Nosocomial infections are a major threat to modern therapeutics. The causative agent of these is multidrug-resistant gram-negative bacteria, which impart high morbidity and mortality rate. This has led an urge for the development new antibiotics. Antimicrobial photodynamic therapy promising strategy till date no resistant strain been reported. Since efficacy largely depends on selection administration appropriate photosensitizer, therefore, realization clinically active photosensitizers...
Under hyperglycaemic conditions non-enzymatic glycation of proteins gives rise to advanced end products (AGEs).
Background Cisplatin is an effective anticancer drug that elicits many side effects mainly due to induction of oxidative and nitrosative stresses during prolonged chemotherapy. The severity these consequently restricts its clinical use under long term treatment. Riboflavin essential vitamin used in various metabolic redox reactions the form flavin adenine dinucleotide mononucleotide. Besides, it has excellent photosensitizing property can be ameliorate toxicities mice photodynamic therapy....
5-Fluorouracil (5-FU) is a potent photosensitizer used in colon and rectal cancers. 5-FU on galvanostatic electrolysis or radiation-induced oxidation of aqueous solution yields N(1)-C(5)-linked dimmer hydrate 5-FU. Copper presently associated with chromatin; cancer cells the concentration copper very high. It has been shown to be capable mediating action several anticancer drugs through production reactive oxygen species (ROS). The objective present study determine Cu (II)-mediated mechanism...
Quercetin is a natural polyphenolic compound that acts as strong antioxidant for reactive oxygen species (ROS) generated by any physical or chemical action.
We have earlier elucidated a pathway for the anticancer action of plant polyphenolic compounds against malignant cells involving mobilisation endogenous copper ions and consequent prooxidant action. To further confirm our hypothesis in vivo, we induced hepatocellular carcinoma (HCC) rats by diethylnitrosamine (DEN). show that such cells, there is progressive elevation levels at various intervals after DEN administration. Concurrently with increasing levels, epigallocatechin-3-gallate (EGCG;...
Despite substantial research on cancer therapeutics, systemic toxicity and drug-resistance limits the clinical application of many drugs like cisplatin. Therefore, new chemotherapeutic strategies against different malignancies are needed. Targeted therapy is a paradigm for therapeutics which targets pathways or chemical entities specific to cells than normal ones. Unlike cells, contain elevated copper plays an integral role in angiogenesis. Copper important metal ion associated with...