A5061196152- Phytochemicals and Antioxidant Activities
- Parasites and Host Interactions
- Trace Elements in Health
- Vitamin D Research Studies
- Vitamin C and Antioxidants Research
- Helminth infection and control
- Parasite Biology and Host Interactions
- Synthesis and biological activity
- Protein Interaction Studies and Fluorescence Analysis
- Genomics, phytochemicals, and oxidative stress
- Synthesis and Characterization of Heterocyclic Compounds
- Protein Structure and Dynamics
- Tea Polyphenols and Effects
- Insect Pest Control Strategies
- Heavy Metals in Plants
- Computational Drug Discovery Methods
- PARP inhibition in cancer therapy
- Fullerene Chemistry and Applications
- Free Radicals and Antioxidants
- DNA Repair Mechanisms
- Carbon Nanotubes in Composites
- Synthesis and Biological Evaluation
- Heavy Metal Exposure and Toxicity
- Polymer Nanocomposite Synthesis and Irradiation
- Aluminum toxicity and tolerance in plants and animals
Aligarh Muslim University
2014-2024
Université Laval
2021
The Ohio State University
2014-2018
Nosocomial infections are a major threat to modern therapeutics. The causative agent of these is multidrug-resistant gram-negative bacteria, which impart high morbidity and mortality rate. This has led an urge for the development new antibiotics. Antimicrobial photodynamic therapy promising strategy till date no resistant strain been reported. Since efficacy largely depends on selection administration appropriate photosensitizer, therefore, realization clinically active photosensitizers...
Anthocyanidins are the most abundant polyphenols in pomegranate juice. This class of molecules includes Delphinidin (Del), Cyanidin (Cya), and Pelargonidin (Pel). Using prostate, breast pancreatic cancer cell lines PC3, MDA-MB-231, BxPC-3 MiaPaCa-2, we show that anthocyanidins inhibit proliferation (measured by MTT assay) induce apoptosis like death DNA/Histone ELISA). Copper chelator neocuproine reactive oxygen species scavengers (thiourea for hydroxyl radical superoxide dismutase anion)...
The possible roles of elevated endogenous copper levels in malignant cells are becoming increasingly understood at a greater depth. Our laboratory has previously demonstrated that tea catechins have the ability to mobilize and undergo Fenton-like reaction can selectively damage cancer cells. In this communication, by using diverse panel cell lines, we demonstrate catechin family [(-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC), (-)-epicatechin (EC), (+)-catechin (C)] induce...
We have earlier elucidated a pathway for the anticancer action of plant polyphenolic compounds against malignant cells involving mobilisation endogenous copper ions and consequent prooxidant action. To further confirm our hypothesis in vivo, we induced hepatocellular carcinoma (HCC) rats by diethylnitrosamine (DEN). show that such cells, there is progressive elevation levels at various intervals after DEN administration. Concurrently with increasing levels, epigallocatechin-3-gallate (EGCG;...
Cancer stem cells (CSCs) represent the root of many solid tumors including ovarian cancer. Eradication CSCs represents a novel cancer therapeutic strategy. Calcitriol, also known as 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is an active metabolite vitamin D, functioning potent steroid hormone. Calcitriol has shown anti-tumor effects in various cancers by regulating multiple signaling pathways. It been reported that calcitriol can regulate properties normal and CSCs. However, effect on growth...
The landscapes in Zagros Mountains SW Iran are greatly influenced by structural geology, tectonics, and bedrock lithology, the courses of major rivers. locations valleys rivers within Fold Belt central largely determined two rivers, Karun Dez, which particularly topographic barrier Mountain Front Fault lows its associated lateral ramps. At finer scales river more variable, with similar reaches tectonic scenarios apparently having different responses; diverting around uplifting areas some...
BackgroundVitamin D is known to play an important role in cancer-prevention. One of the features associated with onset malignancy elevation Cu (II) levels. The mode cancer-prevention mediated by calcitriol, biologically active form vitamin D, remain largely unknown. MethodsUsing exogenously added stimulate a like condition novel cellular system rabbit calcitriol overloaded lymphocytes, we assessed lipid peroxidation, protein carbonylation, DNA damage and consequent apoptosis. Free radical...
Vitamin D (vit D) is a known anticancer molecule, and cancer cells are reported to have elevated levels of Cu(II) ions. In this study, we show that interaction vit leads the formation hydroxyl free radicals, superoxide anion hydrogen peroxide, which causes severe oxidative stress, selectively in malignant cells. We production these reactive oxygen species cellular DNA fragmentation may cause cell death. A novel putative chemical mechanism explaining how death by damage, cells, proposed.
Abstract Calcitriol, the biologically active form of vitamin D, is known to function as an important anticancer agent. The exact mechanism by which calcitriol exerts its effects remains unknown. Recent evidence suggests a link between calcitriol‐induced, free‐radical‐mediated DNA damage and cell death, in presence elevated levels copper, such those observed malignant cells. As lipid‐soluble molecule, interaction with copper would require “chaperone”‐like binds relatively hydrophobic polar...
Catalase, a ubiquitous enzyme of the free radical scavenging machinery unfolds and aggregates in presence 2,2,2-triflouroethanol (TFE). Catalase molecule at 50% TFE as evident by high thioflavin T fluorescence, shifted congo red absorbance, change circular dichroism soret spectra. TEM images confirmed nature catalase to be oligomers. Organic solvent-induced aggregation is prevented peroxidase (another machinery). To alter progress increasing concentration TFE, we determined effect on...