M.A. Gonzalez Ruiz

ORCID: 0000-0003-0561-0695
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About
Contact & Profiles
Research Areas
  • Prostate Cancer Treatment and Research
  • Metabolomics and Mass Spectrometry Studies
  • Adipose Tissue and Metabolism
  • Neutropenia and Cancer Infections
  • Protease and Inhibitor Mechanisms
  • Breast Implant and Reconstruction
  • Hematological disorders and diagnostics
  • Immune Cell Function and Interaction
  • Artificial Intelligence in Healthcare
  • Advanced Radiotherapy Techniques
  • Nanoplatforms for cancer theranostics
  • Antibiotic Resistance in Bacteria
  • Estrogen and related hormone effects
  • Cancer Treatment and Pharmacology
  • Antibiotics Pharmacokinetics and Efficacy
  • Breast Cancer Treatment Studies
  • Systemic Sclerosis and Related Diseases
  • Peptidase Inhibition and Analysis
  • Extracellular vesicles in disease
  • Gastric Cancer Management and Outcomes
  • Bacterial Identification and Susceptibility Testing
  • Diet, Metabolism, and Disease
  • Explainable Artificial Intelligence (XAI)
  • Computational Drug Discovery Methods
  • Lymphatic System and Diseases

Université de Montréal
2024-2025

Montreal Heart Institute
2024-2025

Hospital Universitario Infanta Cristina
2018

Vall d'Hebron Hospital Universitari
2015

Universidade de São Paulo
2007

Hospital de Base
2007

Abstract Lean patients with NAFLD may develop cardiac complications independently of pre-existent metabolic disruptions and comorbidities. To address the underlying mechanisms independent development obesity, we used a murine model hepatic mitochondrial deficiency. The liver-heart axis was studied as these mice microvesicular steatosis without obesity. Our results unveil sex-dependent phenotypic remodeling beyond liver damage. Males, more than females, show fasting hypoglycemia increased...

10.1038/s42003-024-06035-6 article EN cc-by Communications Biology 2024-03-22

Lymphatic vessels are essential for preventing the accumulation of harmful components within peripheral tissues, including artery wall. Various endogenous mechanisms maintain adequate lymphatic function throughout life, with platelets being preserving vessel integrity. However, since lymph lacks platelets, their impact on system has long been viewed as restricted to areas where lymphatics intersect blood vessels. Nevertheless, can also exert range effects through release extracellular...

10.1038/s42003-024-06675-8 article EN cc-by-nc-nd Communications Biology 2024-08-11

Abstract Understanding molecular traits through metabolomics offers an avenue to tailor cardiovascular prevention, diagnosis and treatment strategies more effectively. This study focuses on the application of machine learning (ML) explainable artificial intelligence (XAI) algorithms detect discriminant signatures in heart failure (HF). In this study, we aim uncover metabolites with significant predictive value by analyzing targeted data ML models XAI methodologies. After robust quality...

10.1101/2024.10.04.616718 preprint EN cc-by-nc bioRxiv (Cold Spring Harbor Laboratory) 2024-10-07

4654 Background: PCK3145 is a 15-mer synthetic peptide derived from Prostate Secretory Protein (PSP94). PSP94 down regulated in advanced prostate cancer suggesting role as survival mechanism for cells. PCK3145, PSP94, demonstrated anti-tumor activities both vivo and vitro. Its underlying of action thought to be by activation receptor-mediated signal transduction pathways that cause apoptosis normalize matrix metalloproteinase-9 (MMP-9) levels the treated animals. Methods: Given pre-clinical...

10.1200/jco.2005.23.16_suppl.4654 article EN Journal of Clinical Oncology 2005-06-01

Our outcomes following PPB were similar to those published in the literature.Prostate D90, initial PSA level, and GS significantly associated with BFR.We assumed that BFR rate had improved on basis prostate dose increased when compared beginning.

10.1016/s0167-8140(18)31856-5 article EN cc-by-nc-nd Radiotherapy and Oncology 2018-04-01

Material and MethodsRetrospective, descriptive study of premenopausal cervix cancer who received radiotherapy at pelvic region Mahavajiralongkorn Thanyaburi Hospital between

10.1016/s0167-8140(18)31823-1 article EN cc-by-nc-nd Radiotherapy and Oncology 2018-04-01

Our outcomes following PPB were similar to those published in the literature.Prostate D90, initial PSA level, and GS significantly associated with BFR.We assumed that BFR rate had improved on basis prostate dose increased when compared beginning.

10.1016/s0167-8140(18)31857-7 article EN cc-by-nc-nd Radiotherapy and Oncology 2018-04-01

10.1016/s0167-8140(19)31482-3 article EN cc-by-nc-nd Radiotherapy and Oncology 2019-04-01
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