A5003580560- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- CAR-T cell therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Nanoplatforms for cancer theranostics
- CRISPR and Genetic Engineering
- Immune cells in cancer
- Advanced Drug Delivery Systems
- Glioma Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Photodynamic Therapy Research Studies
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- Renal and related cancers
- Animal Virus Infections Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
Southern University of Science and Technology
2025
State Key Laboratory of Biotherapy
2024
Sichuan University
2024
Zhejiang Sci-Tech University
2016-2020
Hangzhou Medical College
2020
Zhejiang Provincial People's Hospital
2020
Nanomaterial-based mild photothermal therapy (mPTT, 42-45 °C) with controllable light-triggered thermal diffusion holds potential in reversing immunosuppressive microenvironments and activating antitumor immunity tumors. However, the limited efficacy of mPTT alone always requires sophisticated synergistic strategies to promote its overall therapeutic outcome. Herein, we employ an immune-active natural polymer, peach gum polysaccharide (PGP), as nanocarrier encapsulate reagent TTQPL yield...
During the past few decades, colorectal cancer (CRC) incidence and mortality have significantly increased, CRC has become leading cause of cancer-related death worldwide. Thus, exploring novel effective therapies for is imperative. In this study, we investigated effect oncolytic adenovirus CD55-Smad4 on cell growth. Cell viability assay, animal experiments, flow cytometric analysis, migration, invasion assays, Western blotting were used to detect proliferation, apoptosis, cells. The was...
Interleukin 24 (IL-24) is an IL-10 family member and a secreted cytokine characterized by cancer-targeted toxicity can activate apoptosis sensitizing cancer cells to chemotherapy. Cytotoxic effects of luteolin on different types suppress their growth acting the components signaling cascade. Therefore, our study aimed prove whether oncolytic vaccinia virus (VV) that harbors IL-24 (VV-IL-24) combine with exerts synergistic inhibitory effect in liver cells.
In recent years, oncolytic viruses have attracted increasing interest due to their potent antitumor effects. Luteolin, a natural product, has additionally been observed exhibit various pharmacological activities. Previously, novel dual‑targeting adenovirus, complement decay‑accelerating factor (CD55)‑tumor necrosis ligand superfamily member 10 (TRAIL), was constructed, which exhibited significant growth inhibitory effects in types of tumor cell. The present study investigated whether the...
Oncolytic adenovirus (OA) has attracted increasing attention due to their specific proliferation in tumour cells and resulting lysis of cells. To further improve the antitumour effect OA, this study, we combined CD55-TRAIL-IETD-MnSOD (CD55-TMn), a CEA-controlled OA constructed previously, chemotherapy investigate synergistic possible mechanisms. MTT assay was performed detect effects. Hoechst 33 342 flow cytometric analysis were used examine cell apoptosis. Western blotting pyroptosis...
Nicotinamide and tryptophan metabolism play important roles in regulating tumor synthesis signal transduction functions. However, their comprehensive impact on the prognosis immune microenvironment of glioma is still unclear. The purpose this study was to investigate association nicotinamide with status gliomas develop relevant models for predicting sensitivity immunotherapy gliomas. Bulk single-cell transcriptome data from TCGA, CGGA GSE159416 were obtained study. Gliomas classified based...