A5101667959- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- HIV-related health complications and treatments
- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Hematopoietic Stem Cell Transplantation
- Eosinophilic Disorders and Syndromes
- HIV/AIDS Research and Interventions
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- COVID-19 Impact on Reproduction
- Cervical Cancer and HPV Research
- Parvovirus B19 Infection Studies
- Polyomavirus and related diseases
- Cancer Mechanisms and Therapy
- Vascular Tumors and Angiosarcomas
- Immune responses and vaccinations
- Heart Rate Variability and Autonomic Control
- Dermatological diseases and infestations
- Histiocytic Disorders and Treatments
- Tuberculosis Research and Epidemiology
- Chemokine receptors and signaling
University of Virginia
2024
University of Arkansas for Medical Sciences
2019-2020
University of Arkansas at Little Rock
2020
Government Medical College
2018
National Institutes of Health
2008-2017
National Institute of Allergy and Infectious Diseases
2013-2017
Brookdale University Hospital and Medical Center
2009-2010
National Heart Lung and Blood Institute
2008
Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an aberrant response occurring in a subset of TB-HIV co-infected patients initiating anti-retroviral therapy (ART). Here, we examined monocyte activation by prospectively quantitating pro-inflammatory plasma markers and subsets from South Indian cohort at baseline following ART initiation the time IRIS, or equivalent points non-IRIS controls. Pro-inflammatory biomarkers innate myeloid cell were...
Activated monocytes in blood promote chronic inflammation and persistent coagulation HIV-infected patients SIV-infected macaques.
Soluble biomarkers of inflammation predict non-AIDS related morbidity and mortality among human immunodeficiency virus (HIV)-infected persons. Exploring associations between plasma cellular phenotypes may identify sources excess inflammation.Plasma (interleukin 6 [IL-6] level, D-dimer high-sensitivity C-reactive protein [hsCRP] soluble CD14 [sCD14] CD163 [sCD163] level) were measured from cryopreserved samples the Study to Understand Natural History HIV/AIDS in Era Effective Therapy (SUN...
Identifying immunologic mechanisms that contribute to premature cardiovascular disease (CVD) among HIV-positive patients will inform prevention strategies.Coronary artery calcium (CAC) progression was studied in an HIV cohort. Immunophenotypes were measured on baseline cryopreserved peripheral blood mononuclear cells using multicolor flow cytometry. Logistic regression identified predictors of CAC after adjusting for traditional and HIV-related risk factors.Baseline characteristics the...
Background The tumor microenvironment (TME) is increasingly appreciated as an important determinant of cancer outcome, including in multiple myeloma (MM). However, most studies have been based on bone marrow (BM) aspirates, which often do not fully reflect the cellular content BM tissue itself. To address this limitation research, we systematically characterized whole (WBM) during premalignant, baseline, treatment, and post-treatment phases. Methods findings Between 2004 2019, 998 samples...
The authors declare no conflicts of interest.
<p><strong>Background:</strong> Diabetes mellitus is a modern epidemic which leads to various complications over period of time. Autonomic neuropathy one such complication may lead on gallbladder dysmotility and stones.</p><p><strong>Objectives:</strong> To determine the incidence disorders in patients type 2 diabetes find out autonomic dysfunction correlate it with presence gall bladder disorders.</p><p><strong>Material...
Abstract Epidermodysplasia verruciformis (EV) is a rare inherited or acquired genodermatosis caused by increased susceptibility to infection the beta subtypes of human papillomavirus (HPV). The co‐occurrence EV with high‐risk (HR) HPV leading cervical dysplasia unreported in literature date. We report patient who developed extensive anogenital and linked concurrent HR‐HPV infection. Literature review suggests that there negative correlation cancer EV, which this patient's presentation course...
Histiocyte-rich pseudotumors (HRPT) developing postchemoradiation therapy are a florid response to treatment and reparative change. Although these benign processes, clinically radiologically, may mimic recurrent/relapsed disease. We describe case of an adult male with history diffuse large B-cell lymphoma (DLBCL), status therapy, who developed HRPT at the site original involvement, mimicking relapse disease on positron emission tomography/computed tomography (PET/CT) imaging. This is one few...
To the Editor: Extramedullary multiple myeloma (EMM) is an aggressive sub entity of (MM) characterized by ability MM cells to proliferate outside bone marrow (BM) and associated with overall poor prognosis. There appears be heterogeneity in outcome between locations EM disease (EMD), central nervous system (CNS) involvement transformation into leukemic phase, termed plasma cell leukemia (PCL) being forms EMD survival <6 months.1-4 Testicular extremely rare course remains largely unexplored.5...
Abstract Except allogenic bone marrow transplantation with either myeloablative or reduced intensity conditioning, there is no effective treatment for PMF. Age-related morbility and mortality factors limit this application. Anti-Jak2 relieves splenomegaly but does not improve cytopenia. IMiDs on the other hand can anemia in up-to 20% of transfusion dependent anemic patients In order to asses underlying mechanism predict responsiveness, vitro suppression Treg cells by lenalidomide correlated...
Transplantation: July 27, 2008 - Volume 86 Issue 2S p 316 doi: 10.1097/01.tp.0000331855.41561.ae