A5073820687- RNA modifications and cancer
- RNA Research and Splicing
- Pancreatic function and diabetes
- Signaling Pathways in Disease
- RNA and protein synthesis mechanisms
- Cellular transport and secretion
Centre for Genomic Regulation
2022
INCLIVA Health Research Institute
2021
Abstract RNA-binding proteins (RBPs) have been relatively overlooked in cancer research despite their contribution to virtually every hallmark. Here, we use RNA interactome capture (RIC) characterize the melanoma RBPome and uncover novel RBPs involved progression. Comparison of RIC profiles a non-tumoral versus metastatic cell line revealed prevalent changes capacities that were not associated with RBP levels. Extensive functional validation selected group 24 using five different vitro...
Abstract Heart failure (HF) and the development of chronic kidney disease (CKD) have a direct association. Both can be cause consequence other. Many factors are known, such as diabetes or hypertension, which lead to appearance and/or these two conditions. However, it is suspected that other factors, namely genetic ones, may explain differences in manifestation progression HF CKD among patients. One candidate factor Rph , gene expressed nervous excretory system mammals Drosophila, encoding...