A5076283213- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Dementia and Cognitive Impairment Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Cerebral Venous Sinus Thrombosis
- Alzheimer's disease research and treatments
- Systemic Lupus Erythematosus Research
- Dialysis and Renal Disease Management
- Advanced X-ray and CT Imaging
- Neurological Disease Mechanisms and Treatments
- Blood transfusion and management
- Health and Medical Research Impacts
- Cardiovascular Health and Disease Prevention
- Biomedical and Engineering Education
- Infectious Encephalopathies and Encephalitis
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Growth Hormone and Insulin-like Growth Factors
- Pathogenesis and Treatment of Hiccups
- Muscle and Compartmental Disorders
- Mitochondrial Function and Pathology
- Neurological Disorders and Treatments
University of Rome Tor Vergata
2019-2025
Policlinico Tor Vergata
2021-2024
Azienda Ospedaliera Santa Maria Degli Angeli
2021
Abstract Although direct oral anticoagulants (DOACs) are non-inferior to Vitamin K antagonists (VKA) in preventing ischemic stroke (IS) atrial fibrillation (AF) patients, there limited data regarding severity and prognosis of patients admitted with IS during DOAC treatment. We performed a single center retrospective study including AF on the Emergency Department for were included. The primary endpoint was analyse evaluated through NIHSS scale according anticoagulant therapy. secondary...
Background. Statins appear to be useful in patients with acute ischemic stroke. Our aim was evaluate the association between premorbid statin treatment and CT perfusion characteristics of Methods. A retrospective analysis stroke secondary occlusion large vessels anterior circulation performed assess collateral flow, core volume, penumbra using angiography maps. Fisher’s exact test used compare baseline two groups. The Wilcoxon rank-sum for independent groups all variables obtained different...
Background Acute stroke patients with comorbid cancer (CC) are more preferably addressed endovascular treatment (EVT) than thrombolytic therapy, due to the presumed potential risk of hemorrhagic transformation and systemic bleeding. This study aims evaluate clinical procedural outcomes acute CC receiving EVT. Methods Using Italian Registry Endovascular Treatment in Stroke, we reviewed prospectively collected data treated EVT from 2011 2017. Outcome measures were modified Thrombolysis...
Diabetes mellitus (DM) is considered a risk factor for Alzheimer's disease (AD) and shares some pathological pathways, such as activation of amyloid cascade tau phosphorylation. The aim the present study was to investigate what extent DM could impact on neurodegeneration within AD continuum, using β (A: Aβ1-42 ) phosphorylated (T: p-tau) biomarkers discriminate patients by change (A+/T-) (A+/T+), according National Institute Aging Association classification. In addition, we aimed evaluate...
Abstract Background and purpose Alzheimer's disease (AD) is considered a clinical biological continuum identified via cerebrospinal fluid (CSF) or imaging biomarkers. Chronic hypoperfusion held as one of the main features disease, part processes causing neuronal degeneration. The mechanism responsible for such condition still debated, although recently direct connection with amyloid peptides has been shown. Here aim was to investigate whether measures change along AD continuum. Methods...
Background: The predictors of intracranial haemorrhagic transformation (HT) in acute ischaemic stroke (AIS) patients undergoing dual antiplatelet therapy (DAPT) are not well known. Objectives: aim this study is to identify the possible clinical and radiological HT patients, irrespective indication for treatment. Design: This a monocentric cohort retrospective study. Methods: We enrolled consecutive AIS from our prospective register, admitted Stroke Unit between June 2021 2023 DAPT with...
Background: CT perfusion (CTP) is used in patients with anterior circulation acute ischemic stroke (AIS) for predicting the final infarct volume (FIV). Tandem occlusion (TO), involving both intracranial large vessels and ipsilateral cervical internal carotid artery could generate hemodynamic changes altering parameters. Our aim to evaluate accuracy of CTP prediction FIV TOs. Methods: consecutive AIS due middle cerebral occlusion, referred a tertiary center between March 2019 January 2021, an...
Background Cognitive impairment (CI) in systemic lupus erythematosus (SLE) is a frequent neuropsychiatric manifestation affecting several domains, even apparently asymptomatic patients. Current research revealed that the typical CI pattern affects frontal-subcortical circuit and thus executive functions. The of non-literal language or pragmatic (PL), including metaphors, idioms, inferences irony has been well described conditions such as autism disorders, Parkinson’s disease, brain injury...
Few experiences on vertebrobasilar occlusion over underlying intracranial atherosclerotic disease have been reported in literature and the optimal strategy how to perform a mechanical thrombectomy is unclear. The aim of this paper bring our experience based patients admitted with acute atheromatous lesions.
Abstract Background and purpose Only a restricted number of elderly patients has been included in the majority recent endovascular stroke trials. We provided an analysis about differences outcomes after mechanical thrombectomy (MT) according to age. Methods A retrospective observational registry with anterior large vessel acute ischemic was performed. Main performed comparing <80 vs. ≥80 years old. sensitivity 3 age groups: i) years; ii) 80–84 iii) ≥85 years. Outcomes were: any...
Efficacy, safety and tolerability of lacosamide in the treatment status epilepticus are well described. However, other evidence its pharmacologic profile elderly patients with comorbidities seems warranted. We describe case an 80 year-old woman history arterial hypertension, ischemic cardiomyopathy, COPD, CKD, previous laryngeal cancer, a stoma positioning for diverticular disease surgery left frontal meningioma. Since then, patient developed focal epilepsy she was on levetiracetam valproic...