A5029467525- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
- Advanced Proteomics Techniques and Applications
- Dental Erosion and Treatment
- Dental Radiography and Imaging
- Bone and Dental Protein Studies
- Lipid Membrane Structure and Behavior
- Polymer Surface Interaction Studies
- Protein Structure and Dynamics
- Force Microscopy Techniques and Applications
- Blood properties and coagulation
- Analytical chemistry methods development
- Forensic Toxicology and Drug Analysis
- Bacterial biofilms and quorum sensing
- Protein Hydrolysis and Bioactive Peptides
- Digestive system and related health
- Enzyme Production and Characterization
- Electrochemical Analysis and Applications
- Polyomavirus and related diseases
- Protein Interaction Studies and Fluorescence Analysis
- Neonatal Respiratory Health Research
- Antimicrobial Resistance in Staphylococcus
- Wound Healing and Treatments
- Dental Anxiety and Anesthesia Techniques
- Electrostatics and Colloid Interactions
Saarland University
2016-2022
TU Dresden
2004-2008
Purpose To 1) elucidate individual proteomic profiles of the 3‐min biofilm caries‐active and caries‐free individuals 2) compare these against background caries. Experimental design The initial oral pellicle 12 is generated in situ on ceramics specimens. individual, host‐specific this basic layer are analyzed by a chemical elution protocol combined with an elaborate mass spectrometry evaluated bioinformatically. Results A total 1188 different proteins identified. Additionally, 68 present all...
Dental pellicle formation starts instantaneously after oral hygiene due to the adsorption of salivary proteins all orally exposed surfaces. The acts as a physiological mediator, protects tooth surface from mechanical damages and reduces acid-induced enamel demineralization. aim this pilot study is identify characterize individual proteomic profiles initial formed on dental compare with corresponding saliva analyze specific patterns occurring during formation.The 3-min five subjects in situ...
The use of dental restorative materials is a routine task in clinical dentistry. Upon exposure to the oral cavity, continuous adsorption salivary proteins and other macromolecules all surfaces occurs, representing first step biofilm formation. Different physico-chemical properties substrate potentially influence composition initial biofilm, termed pellicle. This study aimed at characterizing comparing individual proteomic 3-min pellicle formed on bovine enamel six materials.After chemical...
This in situ study aimed to determine and compare the chlorhexidine (CHX) retention oral cavity after application of different CHX pharmaceutical regimens.Five volunteers used treatment regimens including mouth rinses, dental spray toothpaste gel. After regimens, 2-μl samples were taken from saliva buccal mucosa pellicle as well formed on standardized enamel surfaces. Sample collection was conducted at six time points within 12 h. Retention measured using matrix-assisted laser...
<b><i>Aim:</i></b> The present study aimed to evaluate the impact of caries activity on key enzymes and ultrastructure in situ pellicle. <b><i>Methods:</i></b> Pellicle formation was performed bovine enamel slabs. Intraoral exposure (3, 30, 120 min) accomplished by 14 caries-active (DMFS: 22.7 ± 12.1) 13 caries-inactive 1.5 1.8) individuals. enzyme activities (lysozyme, peroxidase, α-amylase, glycosyltransferase [GTF]) pellicle resting saliva...
Abstract Staphylococcus aureus is a common cause of catheter-related blood stream infections (CRBSI). The bacterium has the ability to form multilayered biofilms on implanted material, which usually requires removal medical device. A first major step this biofilm formation initial adhesion artificial surface. Here, we used single-cell force spectroscopy (SCFS) study S. central venous catheters (CVCs). SCFS performed with surfaces naïve CVCs produced comparable maximum forces three types in...
The total amount of albumin and lysozyme adsorbed on different dentally relevant materials like titanium, gold, ceramics, poly(methyl methacrylate) (PMMA) polytetrafluoroethylene (PTFE) was measured by bicinchoninic acid assay (BCA assay) after detachment the proteins from samples. protein separated into loosely firmly protein. parts bound differ remarkably depending material. For albumin, dominates adsorption. In contrast, for is in some cases equal sometimes there more than lysozyme....
An amendment to this paper has been published and can be accessed via a link at the top of paper.