A5018183835- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Protein Structure and Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Bone and Dental Protein Studies
- Advanced Proteomics Techniques and Applications
- Salivary Gland Disorders and Functions
- 14-3-3 protein interactions
- Cancer Immunotherapy and Biomarkers
- Oral microbiology and periodontitis research
- Neurobiology and Insect Physiology Research
- Ion Channels and Receptors
- Protein purification and stability
- Glycosylation and Glycoproteins Research
- Signaling Pathways in Disease
- Protein Kinase Regulation and GTPase Signaling
- Computational Drug Discovery Methods
- Enzyme Structure and Function
- Dental Radiography and Imaging
- Neuropeptides and Animal Physiology
- vaccines and immunoinformatics approaches
- Protein Hydrolysis and Bioactive Peptides
- Biosimilars and Bioanalytical Methods
Saarland University
2020-2023
Dental pellicle formation starts instantaneously after oral hygiene due to the adsorption of salivary proteins all orally exposed surfaces. The acts as a physiological mediator, protects tooth surface from mechanical damages and reduces acid-induced enamel demineralization. aim this pilot study is identify characterize individual proteomic profiles initial formed on dental compare with corresponding saliva analyze specific patterns occurring during formation.The 3-min five subjects in situ...
Alternative splicing is a potent modifier of protein function.Stromal interaction molecule 1 (Stim1) the essential activator store-operated Ca 2+ entry (SOCE) triggering activation transcription factors.Here, we characterize Stim1A, splice variant with an additional 31 amino acid domain inserted in frame within its cytosolic domain.Prominent expression exon A found astrocytes, heart, kidney, and testes.Full-length Stim1A functions as dominant-negative regulator SOCE I CRAC, facilitating...
The use of dental restorative materials is a routine task in clinical dentistry. Upon exposure to the oral cavity, continuous adsorption salivary proteins and other macromolecules all surfaces occurs, representing first step biofilm formation. Different physico-chemical properties substrate potentially influence composition initial biofilm, termed pellicle. This study aimed at characterizing comparing individual proteomic 3-min pellicle formed on bovine enamel six materials.After chemical...
Abstract Despite impressive advances in melanoma-directed immunotherapies, resistance is common and many patients still succumb to metastatic disease. In this context, harnessing natural killer (NK) cells, which have thus far been sidelined the development of melanoma immunotherapy, could provide therapeutic benefits for cancer treatment. To identify molecular determinants NK cell–mediated killing (NKmK), we quantified NK-cell cytotoxicity against a panel genetically diverse cell lines...
Members of the 14-3-3 domain family have important functions as adapter domains. Via an amphipathic groove on their protein surface they typically bind to disordered C-terminals other proteins. Importantly, binding partners domains usually contain a phosphorylated serine or threonine residue at interface and possess one three different sequence motifs. Binding respective unphosphorylated versions peptides is strongly disfavored. There wealth structural thermodynamic data available for forms...
<div>Abstract<p>Despite impressive advances in melanoma-directed immunotherapies, resistance is common and many patients still succumb to metastatic disease. In this context, harnessing natural killer (NK) cells, which have thus far been sidelined the development of melanoma immunotherapy, could provide therapeutic benefits for cancer treatment. To identify molecular determinants NK cell–mediated killing (<i>NKmK</i>), we quantified NK-cell cytotoxicity against a...
<p>A file containing supplementary figures 1-8 and the table S1.</p>
<p>A file containing RPPA and RNAseq datasets, pathway analyses prediction calculations presented in the main figures.</p>
<p>A file containing RPPA and RNAseq datasets, pathway analyses prediction calculations presented in the main figures.</p>
<p>A file containing supplementary figures 1-8 and the table S1.</p>
<div>Abstract<p>Despite impressive advances in melanoma-directed immunotherapies, resistance is common and many patients still succumb to metastatic disease. In this context, harnessing natural killer (NK) cells, which have thus far been sidelined the development of melanoma immunotherapy, could provide therapeutic benefits for cancer treatment. To identify molecular determinants NK cell–mediated killing (<i>NKmK</i>), we quantified NK-cell cytotoxicity against a...
PSD-95/discs-large/ZO-1 (PDZ) domains form a large family of adaptor proteins that bind to the C-terminal tails their binding partner proteins. Via extensive molecular dynamics simulations and alchemical free energy calculations, we characterized modi phosphorylated unphosphorylated EQVSAV peptides EQVEAV phosphate mimic hPTP1E PDZ2 MAGI1 PDZ1 domains. The reproduced well-known characteristics such as tight coordination peptidic carboxyl tail pronounced hydrogen bonding between peptide...