Background Despite their revolutionary success in cancer treatment over the last decades, immunotherapies encounter limitations certain tumor types and patients. The efficacy of depends on antigen-specific CD8 T-cell viability functionality within immunosuppressive microenvironment, where oxygen levels are often low. Hypoxia can reduce fitness several ways T cells mostly excluded from hypoxic regions. Given challenges to achieve durable reduction hypoxia clinic, ameliorating survival...

Abstract GrafeoPlad‐Pd, a new metal‐organic alloy comprised of Pd nanoparticles doped with 3D‐entrapped graphene oxide, has promising applicative potential in sustainable synthetic organic chemistry. Besides hydrogenation, the metal nanopowder comprising material is also active and relatively stable cross‐coupling reactions carried out consecutively. X‐ray photoelectron spectroscopy (XPS) surface investigation density functional theory (DFT) calculations are applied to gain insight into...

The reduced form of NiGraf, a newly developed metal organic alloy comprised graphene oxide entrapped within Ni-based nanoparticles subsequently with thiophene (RGO@Ni), shows re-markably stable selective activity in the complete reduction nitrobenzene to aniline carried out liquid-phase under ultramild conditions (35 °C, 10% excess hydrazine as reductant). These results are practically relevant because molecularly doped metals hold great applicative potential new-generation solid catalysts,...

Graphene was encapsulated within the crystal lattice of Cu via chemical route to molecularly doped metals affording an excellent electrical conductor dubbed herein “CuproGraf”. Metal bars in CuproGraf embedding less than 0.5 wt% graphene obtained by heating followed hot rolling have conductivity as high 7% made from pure copper. Considering ease preparation, and that substantial room for improvement exists adopting a different powder agglomeration route, method is promising towards...

Overpromising has been a constant trait of the nanosciences, and case nanocellulose makes no exception. Regardless substantial academic industrial research efforts re-started in early 2000s, global production 2018 amounted to less than 40,000 tonnes, chiefly form microfibrillated cellulose for low value utilization paper cardboard products. Since 2000s market analysts regularly estimate large annual growth rates that so far never materialized. Besides replacement conventional methods with...

Abstract The versatility of a nitrogen rich pyridinic derivative the cyclic triimidazole scaffold with C 3 symmetry is here exploited to obtain three luminescent coordination polymers (CPs). By reaction 3,7,11‐tri(pyridin‐4‐yl)triimidazo[1,2‐ :1′,2′‐ c :1′′,2′′‐ e ][1,3,5]triazine, (4 py) TT , Ag(I), Cd(II) and Cu(I) salts, [Ag{(4‐py) TT}(SO CF )] n ⋅ CH 2 Cl [Cd{(4‐py) TT}(NO ) (EtOH)] [(Cu I {(4‐py) TT} 4 ] xn (H O,EtOH) are obtained. trigonal results in 2D structures hcb topology rare...

By encapsulating graphene oxide in palladium metal nanoparticles and reporting the first application of resulting metal-organic alloys to nitrobenzene hydrogenation with hydrazine at room temperature, we introduce a completely new class catalytic materials dubbed herein “GrafeoPlad” for designing platinum-group metals doped 3D entrapped oxide. This hybrid opens practically relevant perspectives many areas today’s catalysis science technology.

The study of green chemistry uptake in Italy and Spain its first two decades (1999–2019) offers numerous research policy lessons to makers chemical industry managers based other countries. Both academic communities showed immediate interest the new approach productions on concepts pollution accident prevention, hazard elimination, design for degradation. Spain's community acted an organized manner was able attract tens students master doctoral international programs. Revealing differences...

Endowed with exceptional chemical and physical properties that make it potentially useful in a wide array of industrial sectors, nanocellulose remains niche product chiefly manufactured the form microfibrillated cellulose for low value utilization paper cardboard products. This study first shows case adds to many other cases overpromising typical nanosciences. Hence, suggests fulfilling potential may benefit from main lesson learned during hype technology cycle (attention trigger, peak...

Research conducted on the degradation of cultural and architectural heritage caused by deposition air pollutants indicates that both sulphur dioxide particulate matter produced combustion fossil fuels are main agents responsible for deterioration carbonate materials.The chemical process is sulphation substrate which consists in initial conversion (SO2) into sulphuric acid (H₂SO₄) subsequent reaction with calcium carbonate.This leads to formation black crusts, composed gypsum inside...

Abstract Ranging from silver‐entrapped dyes and gold‐entrapped enzymes through palladium‐entrapped graphene oxide, molecularly doped metals (or metal organic alloys, MORALs) are active, stable uniquely versatile catalysts in a number of reactions relevance to the chemical industry. Reactions successfully catalyzed by MORALs concern both industry's main sectors, producing bulk fine chemicals. Though first reported 2005, clearly holding great applicative potential, their use catalysis is still...

GrafeoPlad Palladium In article number 2300643, Maria Pia Casaletto, Mario Pagliaro, Cristina Della Pina, Valeria Butera, Rosaria Ciriminna, and co-workers show that the 3D entrapment of graphene oxide molecules in lattice Pd nanoparticle crystallites establishes a new class hybrid materials, called "GrafeoPlad", may soon find wide applications numerous areas today's material science technology.

Water-soluble graphene oxide was encapsulated within the lattice of Pd nanoparticles using Zn as reducing agent affording a completely new class functional materials dubbed herein "GrafeoPlad" for designating platinum-group metals doped with 3D entrapped oxide. The first application this metal-organic alloy reported is in catalysis to convert nitrobenzene analine hydrazine at room temperature. GrafeoPlad-Pd significantly more and stable than black showing that entrapment GO molecules...

Small (NHC)-stabilized Au nanoparticles 2.52 nm in size and nearly monodisperse can be readily reproducibly synthesized starting from a triimidazotriazine functionalized by N-alkylation with benzylbromide. Subsequent ionic exchange [AuCl4]- reduction of the resulting imidazolium tetrachloroaurate affords new (NHC)-protected nanoparticles. These adsorbed on commercial titania affording catalyst exceptional activity selectivity nitrobenzene to aniline at room temperature ambient pressure.

This work presents a theoretical and empirical evaluation of the Anderson–Darling test when sample size is limited. The can be used to backtest risk factor dynamics in context counterparty credit modeling. We show limits backtesting distributions an interest rate model over long time horizons, we propose modified version it that more efficiently detect underestimation model’s volatility. Finally, provide application.

The degradation of cultural assets exposed in out-of-door environments is a continuous and irreversible phenomenon that largely accelerated by anthropogenic pollution.Various phenomena can develop on stone surfaces among which one the most important formation black crusts are created areas protected from runoff.The development these patinas very complex understanding their genesis could be fundamental preventing decay monuments.This research shows results second exposure campaign ageing...

The degradation of cultural assets exposed in out-of-door environments is a continuous and irreversible phenomenon that largely accelerated by anthropogenic pollution.Various phenomena can develop on stone surfaces among which one the most important formation black crusts are created areas protected from runoff.The development these patinas very complex understanding their genesis could be fundamental preventing decay monuments.This research shows results second exposure campaign ageing...

Credibility theory provides tools to obtain better estimates by combining individual data with sample information. We apply the a Uniform distribution that is used in testing reliability of forecasting an interest rate for long term horizons. Such empirical exercise asked Regulators (CRR, 2013) validating Internal Model Method Counterparty Credit Risk. The main results risk managers consider more reliable output test limited size when applied define confidence interval.