A5069454228- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Breast Cancer Treatment Studies
- Radiation Therapy and Dosimetry
- Circadian rhythm and melatonin
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Cytokine Signaling Pathways and Interactions
- Medical Imaging Techniques and Applications
- Genetics, Aging, and Longevity in Model Organisms
- Lipid metabolism and biosynthesis
- Radiation Detection and Scintillator Technologies
- Childhood Cancer Survivors' Quality of Life
- Pluripotent Stem Cells Research
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Acute Myeloid Leukemia Research
- Endoplasmic Reticulum Stress and Disease
- Neuroendocrine regulation and behavior
- Spectroscopy and Quantum Chemical Studies
- Nuclear reactor physics and engineering
- Birth, Development, and Health
- Lipid Membrane Structure and Behavior
- Sphingolipid Metabolism and Signaling
- Nuclear Materials and Properties
Sofia University "St. Kliment Ohridski"
1989-2024
Deutsches Elektronen-Synchrotron DESY
2024
Jacobs (United States)
2023
University of Arizona
2011-2016
Kozloduy Nuclear Power Plant
2012
Memorial Sloan Kettering Cancer Center
2011
The University of Texas MD Anderson Cancer Center
2009
Krankenhaus Jerusalem
2007
Institute of Mechanics
2006
Bulgarian Academy of Sciences
1976
Abstract A method for determination of molecular quantum yields fluorescent compounds in solution by internal calibration with the signal spontaneous Raman scattering solvent is proposed. An experimental verification carried out substances known and satisfactory agreement between results literature values obtained.
Combinations of anti-cancer drugs can overcome resistance to therapy and provide new more effective treatments. In this work we have analyzed the effect polyphenol quercetin sphingosine analog fingolimod on sphingolipid metabolism in HepG2 cells, since sphingolipids are recognized as mediators cell proliferation apoptosis cancer cells. Treatment hepatocellular carcinoma cells with fingolimod, alone or combination, induced different degrees sphingomyelin (SM) reduction a corresponding...
Nonhealing wounds are a common complication in patients suffering from diabetes with hyperglycemia being the most deteriorating factor for this serious pathological condition. Despite great body of data, molecular mechanisms by which high glucose affects cellular physiology still poorly defined. Here we used primary human foreskin fibroblasts cultured normo- and hyperglycemic conditions to study leading altered cell contractility. Our results demonstrated that 25 mmol/L effectively reduced...
Melatonin (MEL) may influence the efficiency of reprogramming both by somatic cell nuclear transfer and direct induction pluripotent stem cells (iPSC) through a yet unidentified mechanism. Transcription factors linked to signalling be differentially expressed according differentiation status. To address effect MEL on expression transcription reprogramming, we used two distinct in vitro models cellular plasticity: human foreskin fibroblasts (HFF) primary granulosa-lutein (GLC). Real-time...
Human bestrophin-1 protein (hBest1) is a transmembrane channel associated with the calcium-dependent transport of chloride ions in retinal pigment epithelium as well glutamate and GABA nerve cells. Interactions between hBest1, sphingomyelins, phosphatidylcholines cholesterol are crucial for hBest1 association cell membrane domains its biological functions. As plays key role formation lipid rafts, motional ordering lipids modeling/remodeling lateral structure, we examined effect different...
The polyphenol quercetin is associated with numerous beneficial health effects in various pathologies such as oxidative stress, neurodegenerative disorders, inflammation, neoplastic processes, age-related diseases, and so on. However, the molecular mechanisms underlying of its implication pharmaceutical practice require additional clarification. In this study we analyzed biochemical effect on membrane lipids fibroblasts cultured three-dimensional (3D) cultures, which resemble living tissues...
Abstract An R&D platform for electron FLASH radiation therapy and biology is being prepared at the Photo Injector Test facility DESY in Zeuthen (FLASH lab @PITZ). This based on unique beam parameters available PITZ: ps scale bunches of up to 22 MeV with 5 nC bunch charge MHz repetition rate trains 1 ms length repeating 10 Hz. It works together Technical University Applied Sciences Wildau (TH Wildau) as partner close vicinity biological resources. A startup beamline has been installed...
The studies of rejuvenation are important for promoting health and longevity, preventing age-related diseases, reducing economic burdens, improving quality life addressing the challenges posed by an aging global population. This review explores intersection aging, regeneration bioelectric fields examining emerging role membrane potential in processes like cell proliferation, differentiation, limb potentially aging. Manipulation opens a novel dimension to landscape offering alternative or...
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Immunological risk factors in recurrent pregnancy loss include autoantibodies, alterations NK cell number and function, regulatory T cells, the human leukocyte antigen system (HLA), etc., where treatment options aim to regulate immune dysfunction. Intralipid is a synthetic product traditionally used as dietary supplement consisting of soybean oil combined with refined egg phospholipids. It has been shown that intralipid exerts physiologic activities, including altering immunological...