A5072867594- Cell Adhesion Molecules Research
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Prion Diseases and Protein Misfolding
- HER2/EGFR in Cancer Research
- Reproductive biology and impacts on aquatic species
- Aquaculture Nutrition and Growth
- Monoclonal and Polyclonal Antibodies Research
- Environmental Toxicology and Ecotoxicology
- Neurological diseases and metabolism
- RNA regulation and disease
- Neuroblastoma Research and Treatments
- Hereditary Neurological Disorders
- Cellular transport and secretion
- Marine Toxins and Detection Methods
- Radiation Therapy and Dosimetry
- Cellular Mechanics and Interactions
- Sperm and Testicular Function
- Glycosylation and Glycoproteins Research
- Nerve injury and regeneration
- Receptor Mechanisms and Signaling
- Pancreatic function and diabetes
- Marine Biology and Environmental Chemistry
- Endoplasmic Reticulum Stress and Disease
- Neuroendocrine Tumor Research Advances
Ludwig Cancer Research
2023
Universidade Estadual de Ponta Grossa
2015-2023
Universidade Federal do Paraná
2009-2018
This study investigated the effects of different doses 17-beta-estradiol (E(2)) in Rhamdia quelen. Groups males exposed to E(2) (0.1 mg kg(-)(1), 1 kg(-)(1) and 10 kg(-)(1)) were compared with non-exposed male female fish groups. Among considered biomarkers, no significant differences observed for micronuclei test, reduced glutathione concentration lipid peroxidation. All E(2)-treated individuals had decreased S-transferase activity. Increased catalase superoxide dismutase activities,...
Abstract The ADAM23 gene is frequently silenced in different types of tumors, and, breast silencing correlated with tumor progression, suggesting that it might be associated the acquisition a metastatic phenotype. exerts its function mainly through disintegrin domain, because metalloprotease domain inactive. Analysis binding to integrins has revealed specific interaction αvβ3 integrin mediated by domain. Altered expression been observed and this activated form shown promote metastasis...
ADAMs are transmembrane proteins implicated in several biological functions, including cytokine and growth factor shedding, fertilization, muscle nervous system development. Here, we show for the first time that ADAM23, which is predominantly expressed central system, co-localizes with cellular prion protein (PrP(C)) at plasma membrane of mouse hippocampal neurons neuroblastoma cells. Co-immunoprecipitation pull-down assay showed a physical interaction between ADAM23 both recombinant...
Prion diseases involve the conversion of endogenous cellular prion protein, PrP(C), into a misfolded infectious isoform, PrP(Sc). Several functions have been attributed to and its role has also investigated in olfactory system. PrP(C) is expressed both bulb (OB) epithelium (OE) nasal cavity an important route transmission caused by prions. Moreover, Prnp(-/-) mice showed impaired behavior tests. Given high expression OE putative olfaction, we screened mouse cDNA library identify novel...
Scrapie é uma doença que afeta ovinos e caprinos, sendo definida pelo acúmulo de isoforma anormal (PrPSc) da proteína priônica celular (PrPC) no Sistema Nervoso Central (SNC) em tecidos linfoides. Para as técnicas eleição do diagnóstico scrapie, imunohistoquímica (IHQ) western blotting (WB), podem ser utilizados vasta gama anticorpos monoclonais policlonais comercialmente disponíveis. O objetivo deste estudo foi testar comparar a eficácia dos disponíveis comercialmente, F89/160.1.5,...
<div>Abstract<p>The <i>ADAM23</i> gene is frequently silenced in different types of tumors, and, breast silencing correlated with tumor progression, suggesting that it might be associated the acquisition a metastatic phenotype. ADAM23 exerts its function mainly through disintegrin domain, because metalloprotease domain inactive. Analysis binding to integrins has revealed specific interaction α<sub>v</sub>β<sub>3</sub> integrin mediated by...
Supplementary Figure 1 from ADAM23 Negatively Modulates α<sub>v</sub>β<sub>3</sub> Integrin Activation during Metastasis
Supplementary Figure 2 from ADAM23 Negatively Modulates α<sub>v</sub>β<sub>3</sub> Integrin Activation during Metastasis
Supplementary Figure 3 from ADAM23 Negatively Modulates α<sub>v</sub>β<sub>3</sub> Integrin Activation during Metastasis
Supplementary Figure 1 from ADAM23 Negatively Modulates α<sub>v</sub>β<sub>3</sub> Integrin Activation during Metastasis
Supplementary Figure 2 from ADAM23 Negatively Modulates α<sub>v</sub>β<sub>3</sub> Integrin Activation during Metastasis
Supplementary Figure 3 from ADAM23 Negatively Modulates α<sub>v</sub>β<sub>3</sub> Integrin Activation during Metastasis
<div>Abstract<p>The <i>ADAM23</i> gene is frequently silenced in different types of tumors, and, breast silencing correlated with tumor progression, suggesting that it might be associated the acquisition a metastatic phenotype. ADAM23 exerts its function mainly through disintegrin domain, because metalloprotease domain inactive. Analysis binding to integrins has revealed specific interaction α<sub>v</sub>β<sub>3</sub> integrin mediated by...