<title>Abstract</title> There are pertinent studies on the relationship between MMPs and muscle cell differentiation in vitro, but there currently few vivo exploring MMP expressions chicken during different stages of differentiation. Therefore, we aimed to investigate vivo, whether MMP-2, MT1-MMP, MMP-9 expressed pectoral development days E11, E15, E19. Our results demonstrated that, contrast earlier reports that primary myotubes formed E11 while E15 E19 is occurring secondary waves. other...

Hemorrhagic shock (HS), which causes insufficient tissue perfusion, can result in multiple organ failure (MOF) and death. This study aimed to evaluate whether doxycycline (DOX) protects cardiovascular, kidney, liver from damage a rat model of HS. Immediately before the resuscitation, DOX (10 mg/kg; i.v.) was administered, its protective effects were assessed 24 h later. Mean arterial pressure, renal blood flow, heart rate, vasoactive drug response, markers such as urea, creatinine, AST, ALT,...

The objective of this in vivo study was to compare the expression matrix metalloproteinases (MMP-2, MMP-8, MMP-9), type I collagen and bone sialoprotein (BSP) infected dentin primary teeth at baseline after cavity sealing with glass ionomer cement. Dentin samples from 45 molars deep active carious lesions were collected before (baseline sample) (60-day sample). fixed, demineralized processed for immunohistochemistry assays. Monoclonal antibodies used localization cited antigens an...

The enamel-related periodontium (ERP) in rat incisors is related to bone resorption. In these teeth the face of socket enamel continuously removed at inner side and newly formed outer side. CSF-1, RANKL OPG are regulatory molecules essential for osteoclastogenesis. To verify effects impeded eruption on remodeling, tooth was prevented by immobilization lower incisor distribution ERP analyzed after 18 days normal eruption. region alveolar crest used. Immunohistochemistry tartrate-resistant...

ABSTRACT The aim of this study was to further define the relationship between cell proliferation and rate tooth eruption in rat incisor. Vinblastine is a drug that blocks cellular mitosis used inhibit odontogenic region incisors were submitted shortening treatment or higher masticatory forces. Male Wistar rats divided into five groups: normofunctional (control group for incisor eruption), hypofunctional (incisor acceleration), hyperfunctional (incisors under forces), with vinblastine...

The small intestine plays a role in obesity as well satiation. However, the effect of physical exercise on morphology and function during has not been reported to date. This study aimed evaluate effects morphological aspects rat hypothalamic monosodium glutamate (MSG)-induced obesity. rats were divided into four groups: Sedentary (S), Monosodium Glutamate (MSG), Exercised (E), (EMSG). MSG EMSG groups received daily injection (4 g/kg) 5 first days after birth. S E considered control...

Background and Objective Doxycycline is an antibiotic agent that inhibits the activity of matrix metalloproteinases ( MMP s) present in extracellular matrix. In this study, rat incisor was submitted to a hypofunctional condition, effects doxycycline (80 mg/kg/d) on expression ‐2, as well eruption rate, were determined odontogenic region periodontal ligament for 14 d. Material Methods Rats distributed into four groups: normofunctional NF ); doxycyline DNF HP DHP ). The left lower incisors 10...

Abstract. Circadian variation in cell proliferation of the jejunal epithelium 18‐day‐old rats was studied using 2‐h arrested metaphase score and crypt isolation method. A continuous decrease metaphases occurred from 07.00 h to13.00 h. From 17.00 values increased were maintained at higher level during dark period as showed by Cosinor analyses ( P &lt; 0.05). These results indicate that young rat there is already a circadian epithelial early 18 days. We can even suggest presence rhythm weaning...

This study investigated the effect of occlusal contact loss (induced by tooth shortening), on matrix metalloproteinase (MMP)-2, membrane type 1-MMP (MT1-MMP) and tissue inhibitor MMP-2 (TIMP-2) expressions in periodontal ligament rat incisor, as well eruption rate, resistance collagen organization.Male Wistar rats were distributed into a control group, denominated normofunctional whose lower teeth underwent normal process; hypofunctional left incisor shortened every 2 days during 14 days....

Abstract Background Calvaria skin has a reduced thickness, and its initial damage produced by irradiation was scarcely reported. We aimed to identify the effects of x-ray in rat calvaria skin. Methods After approval Animal Ethical Committee, sections five Wistar rats per time point were evaluated on days 4, 9, 14, 25 following single 15-Gy head. The control group composed day 4. Sections assessed using hematoxylin-eosin Masson’s trichrome staining for morphology, inflammation, fibrosis....

The lifespan of intestinal epithelial cells is predetermined by the process cell proliferation that occurs constantly in crypt. control this involves some endogenous factors, such as hormones, well exogenous like food and natural light variations. These last two factors seem to be major modulators process. Fasting treatment was conducted assess role its effect on metaphase index (MI) epithelium at different times periods (light dark) day. effects short- (5 hr) long-term (25 fasting MI...

Cell proliferation and migration in the intestinal crypts, cell villus are controlled by different mechanisms adult rats. In present study, weanling rats fasting were used to quantitatively study correlation of cycle parameters epithelial crypts villi. Eighteen-day-old received a single injection tritiated thymidine [3H]TdR (23:00 h); half pups submitted 5 h earlier. was determined radioautographs jejunal on basis labeling indices (LI) taken 1, 8, 13 19 after [3H]TdR. The results showed that...

Cell cycle time (T(C)) and the rate of entry cells into mitosis (r(M)) in jejunum duodenum young rats were investigated using stathmokinetic method. The cell times 24.3 28.3 h light dark periods, respectively. 17.1 21.5 Rates 1.2 1.1 cells/cell/h periods rates 1.4 1.8 Although these changes to values are not statistically significant, variation between two should be considered relation its possible biological effects.

Background: Obesity is a degenerative disease, causing several metabolic disturbances in different systems of the body.However, effects obesity on development mineralized tissues have not been well explored. Objectives:The aim this study was to investigate hypothalamic obesity, induced by monosodium glutamate (MSG) morphometric parameters tibia, hemimandible and incisor tooth rats, as mineral content enamel dentine. Materials Methods:Twelve male Wistar rats were separated Control...

The expressions of matrix metalloproteinases 2 and 9 have been described during the development, as an example in heart tooth but not small intestine yet. In this context, study aimed to evaluate MMP-2 MMP-9 Wistar rats intrauterine (IU) postnatal (PN) life. Expressions were determined on 15th 18th days IU life 3rd, 10th, 17th, 25th, 32nd PN Intestinal samples obtained from six animals submitted zymography, immunohistochemistry, staining with Masson's trichrome. results showed that expressed...