A5050832163- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Hemoglobin structure and function
- Synthesis and Catalytic Reactions
- Medicinal Plants and Bioactive Compounds
- Bioactive Compounds and Antitumor Agents
- Photosynthetic Processes and Mechanisms
- Pediatric health and respiratory diseases
- Herbal Medicine Research Studies
- Marine Toxins and Detection Methods
University of Patras
2021-2024
Academy of Athens
2022
Biomedical Research Foundation of the Academy of Athens
2022
Soluble guanylate cyclase (sGC) is the main receptor of nitric oxide (NO) and by converting GTP to cGMP regulates numerous biological processes. The β 1 subunit most abundant, α heterodimer, harbors an N-terminal domain called H-NOX, responsible for heme NO binding thus sGC activation. Dysfunction NO/sGC/cGMP axis causally associated with pathological states such as heart failure pulmonary hypertension. Enhancement enzymatic function can be effected a class drugs “stimulators,” which depend...
The gasotransmitter nitric oxide (NO) is a critical endogenous regulator of homeostasis, in major part via the generation cGMP (cyclic guanosine monophosphate) from GTP (guanosine triphosphate) by NO's main physiological receptor, soluble guanylate cyclase (sGC). sGC heterodimer, composed an α1 and β1 subunit, which latter contains heme-nitric oxide/oxygen (H-NOX) domain, responsible for NO recognition, binding signal initiation. NO/sGC/cGMP axis dysfunctional variety diseases, including...