A5105411655- Reproductive System and Pregnancy
- Trauma and Emergency Care Studies
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Streptococcal Infections and Treatments
- Neonatal Health and Biochemistry
- Organic Chemistry Cycloaddition Reactions
- biodegradable polymer synthesis and properties
- Cardiac Arrest and Resuscitation
- Cell Adhesion Molecules Research
- Blood properties and coagulation
- Esophageal Cancer Research and Treatment
- Chronic Disease Management Strategies
- 14-3-3 protein interactions
- Autoimmune and Inflammatory Disorders Research
- Neonatal Respiratory Health Research
- Food composition and properties
- Acupuncture Treatment Research Studies
- Neonatal and Maternal Infections
- Photorefractive and Nonlinear Optics
- Cancer Mechanisms and Therapy
- Traumatic Brain Injury Research
- Abdominal Trauma and Injuries
- Renal function and acid-base balance
University of Wisconsin–Madison
2023-2024
LAC+USC Medical Center
2011-2017
University of Southern California
2012-2016
Memorial University of Newfoundland
2011-2015
Illinois College
2015
University of Illinois Urbana-Champaign
2015
Los Angeles Medical Center
2012-2013
Dudley Group NHS Foundation Trust
2013
Commonwealth Medical College
2013
Hospital of the University of Pennsylvania
2012
The textbook mechanism for the addition of a thiol to an olefin is Michael-type addition, which involves nucleophilic attack thiolate anion on alkene form carbanion intermediate. Previous computational models these reactions have proposed alternative mechanisms, as no minimum corresponding intermediate was present potential energy surface. We show that many popular pure and hybrid DFT functionals, such PBE B3LYP, erroneously predict not intermediate, favoring noncovalent charge-transfer...
Cryptococcus neoformans (Cn) is a pathogenic yeast and the cause of cryptococcal meningitis. Prevalence disease between males females skewed, with having an increased incidence disease. Based on reported gender susceptibility differences to Cn in literature, we used clinical isolates from Botswanan HIV-infected patients test hypothesis that different environments exerted selective pressures Cn. When examined this data set, found men had significantly higher risk death despite CD4+ T...
Summary Neutrophils enter tissues including the uterus and are found in endometrium increased numbers prior to menses. In this environment, they exposed transforming growth factor (TGF)-β1 produced by endometrial stromal epithelial cells. We observed that incubation of neutrophils vitro with TGF-β1 at 1 pg/ml significantly reduced their secretion lactoferrin response lipopolysaccharide (LPS). This effect was achieved as little 15 min pretreatment TGF-β1. Inhibition release irrespective...
Abstract A series of zinc complexes was prepared from 4,6‐disubstituted (R,R′) o ‐[(4‐methyl‐1‐piperazinyl)methyl]phenols ([ONN R′,R ]H) and characterized by elemental analysis, 1 H 13 C{ H} NMR spectroscopy, X‐ray crystallography. Reaction these products with diethylzinc gave Zn[ONN t Bu, Bu ] 2 ( ) as a monometallic complex {[μ‐ONN ]ZnEt} [R′ = Me, R ); R′ 3 Am 4 )] bimetallic species that have distorted tetrahedral environments about the Zn centres. alcohols {[ONN Am, ]Zn(μ‐OR″)} [R″ Bn 5...
Necrotizing soft tissue infections (NSTIs) are associated with a high mortality rate. There is lack of literature examining outcomes in NSTI when surgical redébridements performed early versus delayed intervals. We hypothesized that redébridement improved survival. Patients NSTIs were prospectively enrolled between January 2006 and December 2011. Patient demographics, comorbidities, primary infection site, laboratory values, cultures, time to surgery, subsequent débridements obtained. Two...
Problem The role of neutrophils in the human Fallopian tube (FT) is unknown. In order to provide insights into their functions FT, we systematically compared from normal FT and peripheral blood (PB). Method study Flow cytometric analysis surface receptors, granule proteins, intracellular cytokines expressed by enzymatically dispersed PB was performed. Results significantly higher levels CD64, class II histocompatibility antigen DR (HLA‐DR), γ ‐interferon, vascular endothelial growth factor...
Problem The effects of gender and fluctuating ovarian hormones on neutrophil phenotype have yet to be characterized. Method study Neutrophils from females at days 7, 14, 21, 28 the menstrual cycle were analyzed by flow cytometry for surface receptor, granule protein, intracellular cytokine expression. Comparisons made neutrophils males isolated 7‐day intervals during 1 month. Results Decreased MMP‐9 TNF‐α expression was observed periovulatory period. Comparing genders, cells period expressed...
Barrett esophagus is presently defined in the United States by presence of intestinal metaplasia columnar-lined based on premise that risk for adenocarcinoma depends metaplasia. Recently, arguments have been made nonintestinalized cardiac epithelium also at and should be included definition esophagus, as it England Japan. One these residual frequently absent around early adenocarcinomas removed endoscopic mucosal resection (EMR). We reviewed 27 EMRs performed 21 patients. Residual was 10/27...
Scant literature investigates potential outcome differences between Level I trauma centers. We compared overall survival and after acute respiratory distress syndrome (ARDS) in patients admitted to American College of Surgeons (ACS)-verified versus state-verified Using the National Trauma Data Bank Version 7.0, incident codes associated with admission an ACS-verified facility were extracted group Overall, there 382,801 (73.7%) ACS 136,601 (26.3%) state There was no adjusted advantage either...
Summary Neutrophils are a normal constituent of the female reproductive tract and their numbers increase in late secretory phase menstrual cycle prior to menses. Several cytokines produced tissue. In particular granulocyte–macrophage colony‐stimulating factor (GM‐CSF), potent activator neutrophils, is secreted high concentrations by epithelia. We previously observed that GM‐CSF synergizes strongly with interleukin‐8 (IL‐8) enhancing chemotaxis neutrophils. Thus we investigated whether...
The harmful effects of smoking have been well-documented in the medical literature for decades. To further support cessation, we investigate effect on a less studied population, trauma patient.All patients admitted to surgical intensive care unit at LAC + University Southern California center between January 2007 and December 2011 were included. Patients stratified into two groups - current smokers non-smokers. Demographics, admission vitals, comorbidities, operative interventions, injury...
Innate immunity and immunological biomarkers are believed to be interrelated with sex hormones other neuroendocrine factors. Sexual dimorphism mechanisms may operating in certain rheumatic inflammatory diseases which occur more frequently women than men, as rheumatoid arthritis (RA). Less data have been available on altered interrelations of the combined immune (NEI) systems risk factors for development diseases. In this study, serological NEI analyzed before symptomatic onset RA (pre-RA)...
<h3>Background</h3> Recruitment for research studies is a challenging endeavor that was further complicated by the coronavirus disease 2019 pandemic. We launched new multicenter birth cohort, Childhood Allergy and NeOnatal Environment (CANOE), supported National Institutes of Health in January 2020 across 4 sites. Although pandemic temporarily halted clinical research, we restructured study instituted novel recruitment methods hypothesized would enable brisk enrollment when activities...
Accurate characterization of the optical properties erythrocytes is essential for applications in biomedicine, particular, diagnosis blood related diseases. The observed strongly depend on erythrocyte's size, hemoglobin composition and orientation relative to incident light. We explored effect absorption scattering suspended saline using UV-visible spectroscopy theoretical predictive modeling based anomalous diffraction approximation. demonstrate that dilute suspensions not random produces...
<h3>Aims</h3> Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are common co-morbidities. The combination presents diagnostic challenges has been linked with worse prognosis in patients admitted to hospital. There is hardly any prognostic data both co-morbidities the community. <h3>Methods Results</h3> We evaluated 783 (27.2%) left ventricular systolic dysfunction under care of a regional nurse-led community HF team between June 2007 2010. 101 (12.9%) also had diagnosis...
Purpose Exposure to deployment, combat, and other traumatic events can induce a spectrum of physical, cognitive, psychological behavioral effects. This constellation has been termed the “Trauma Spectrum Response” (TSR) includes depression, anxiety, post-traumatic stress disorder (PTSD), brain injury (TBI), sleep disturbances, substance abuse, cognition, headache, pain, spirituality. Acupuncture shown effectively treat such symptoms as insomnia, stress, perceived pain. While many literature...
<h3>Background</h3> Rheumatoid arthritis is characterised by impaired endothelial function which contributes to increased cardiovascular morbidity and mortality. Modern therapies such as tumour necrosis factor alpha antagonists appear reduce risk in this population. Asymmetric dimethylarginine (ADMA) an endogenous competitive inhibitor of nitric oxide synthase dysfunction. <h3>Objectives</h3> The aim the present longitudinal study was investigate effects anti-tumour medications on serum...