A5051706344- Animal Behavior and Reproduction
- T-cell and B-cell Immunology
- Evolution and Genetic Dynamics
- Immune Cell Function and Interaction
- Neuroendocrine regulation and behavior
- Animal Ecology and Behavior Studies
- Olfactory and Sensory Function Studies
- Evolutionary Psychology and Human Behavior
- Genetic diversity and population structure
- Immunotherapy and Immune Responses
- Adipose Tissue and Metabolism
- Plant and animal studies
- Immune Response and Inflammation
- RNA and protein synthesis mechanisms
- Fungal Infections and Studies
- Plant Virus Research Studies
- Aquaculture disease management and microbiota
- vaccines and immunoinformatics approaches
- Primate Behavior and Ecology
- Mathematical and Theoretical Epidemiology and Ecology Models
- Toxin Mechanisms and Immunotoxins
- Birth, Development, and Health
- Neurobiology and Insect Physiology Research
- Subterranean biodiversity and taxonomy
- CRISPR and Genetic Engineering
University of Utah
2015-2025
University of Florida
1990-2017
AstraZeneca (United States)
2008
Wilmington University
2008
Harvard University
2002
Austrian Academy of Sciences
2002
Lincoln University - Missouri
1996
New Frontier
1995
Howard Hughes Medical Institute
1989-1990
München Klinik
1989
House mice prefer mates genetically dissimilar at the major histocompatibility complex (MHC). The highly polymorphic MHC genes control immunological self/nonself recognition; therefore, this mating preference may function to provide "good genes" for an individual's offspring. However, evidence MHC‐dependent preferences is controversial, and its remains unclear. Here we a critical review of studies on in mice, sheep, humans possible functions behavior. There are three adaptive hypotheses...
Genetic heterozygosity is thought to enhance resistance of hosts infectious diseases, but few tests this idea exist. In particular, at the MHC, highly polymorphic loci that control immunological recognition pathogens, suspected confer a selective advantage by enhancing diseases (the "heterozygote advantage" hypothesis). To test hypothesis, we released mice into large population enclosures and challenged them with multiple strains Salmonella one Listeria. We found during infections three...
House mice (Mus musculus domesticus) avoid mating with individuals that are genetically similar at the major histocompatibility complex (MHC). Mice able recognize MHC–similar through specific odour cues. However, to mate disassortatively for MHC genes, must have a referent, either themselves (self–inspection) or close kin (familial imprinting), which compare identity of potential mates. Although studies on MHC–dependent preferences often assume use self–inspection, laboratory experiments...
Long-tailed manakins mate in leks and cooperate multiyear male-male partnerships. An alpha male is responsible for virtually all mating, whereas a beta assists the courtship displays. Such altruism by poses problem evolutionary theory because most theoretical treatments empirical examples of cooperative behavior involve kin selection or reciprocity. Here it shown that partners are not relatives reciprocity involved. Instead, direct, though long-delayed benefits to males demonstrated, which...
The sequential production of cell types during neural development is controlled by temporal identity transcription factors, and heterochronic expression these factors in progenitors reprograms developmental potential promotes the ...Temporal are sufficient to reprogram competence shift fate output, but whether they can also terminally differentiated cells unknown. To address this question, we ...
The detrimental effects of inbreeding on vertebrates are well documented for early stages the life cycle in laboratory. However, consequences long-term survival and reproductive success (Darwinian fitness) uncertain wild. Here, we report direct experimental evidence that competition increases harmful offspring reproduction. We compared fitness inbred (from full-sib matings) outbred wild house mice ( Mus domesticus ) large, seminatural enclosures. Inbred males sired only one-fifth as many...
Genes of the major histocompatibility complex (MHC) play a critical role in immune recognition, and many alleles confer susceptibility to infectious autoimmune diseases. How these deleterious persist populations is controversial. One hypothesis postulates that MHC heterozygote superiority emerges over multiple infections because MHC-mediated resistance generally dominant allele-specific susceptibilities pathogens will be masked by resistant allele heterozygotes. We tested this using...
Males of many species produce scent marks and other olfactory signals that function to intimidate rivals attract females.It has been suggested provide an honest, cheat-proof display individual's health condition.Here we report several findings address this hypothesis in wild-derived house mice (Mus musculus domesticus).(1) We exposed males female odor, which induces increase testosterone, found sexual stimulation significantly increased the males' scent-marking attractiveness their...
Abstract The presentation of protein antigens on the cell surface by major histocompatibility complex (MHC) molecules coordinates vertebrate adaptive immune responses, thereby mediating susceptibility to a variety autoimmune and infectious diseases. composition symbiotic microbial communities (the microbiota) is influenced host immunity can have profound impact physiology. Here we use an MHC congenic mouse model test hypothesis that genetic variation at genes among individuals mediates...
In house mice, and probably most mammals, major histocompatibility complex (MHC) gene products influence both immune recognition individual odours in an allele-specific fashion. Although it is generally assumed that some form of pathogen-driven balancing selection responsible for the unprecedented genetic diversity MHC genes, MHC-based mating preferences observed mice are sufficient to account genes found this other vertebrates. These disassortative completely consistent with conventional...
The unprecedented genetic diversity found at vertebrate MHC (major histocompatibility complex) loci influences susceptibility to most infectious and autoimmune diseases. evolutionary explanation for how these polymorphisms are maintained has been controversial. One leading explanation, antagonistic coevolution (also known as the Red Queen), postulates a never-ending molecular arms race where pathogens evolve evade immune recognition by common alleles, which in turn provides selective...
Cryptococcus neoformans (Cn) is a pathogenic yeast and the cause of cryptococcal meningitis. Prevalence disease between males females skewed, with having an increased incidence disease. Based on reported gender susceptibility differences to Cn in literature, we used clinical isolates from Botswanan HIV-infected patients test hypothesis that different environments exerted selective pressures Cn. When examined this data set, found men had significantly higher risk death despite CD4+ T...
Communication signals are key regulators of social networks and thought to be under selective pressure honestly reflect status, including dominance status. The odours dominants nondominants differentially influence behaviour, identification the specific pheromones associated with, predictive of, status is essential for understanding mechanisms network formation maintenance. In mice, major urinary proteins (MUPs) excreted in extraordinary large quantities expression level has been...
It is often suggested that heterozygosity at major histocompatibility complex (MHC) loci confers enhanced resistance to infectious diseases (heterozygote advantage, HA, hypothesis), and overdominant selection should contribute the evolution of these highly polymorphic genes. The evidence for HA hypothesis mixed mainly from laboratory studies on inbred congenic mice, leaving importance MHC natural populations unclear. We tested by infecting produced crossbreeding C57BL/10 with wild ones,...