A5029496972- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Nitric Oxide and Endothelin Effects
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Mitochondrial Function and Pathology
- Fuel Cells and Related Materials
- Anesthesia and Neurotoxicity Research
- Cardiac Imaging and Diagnostics
- Thermal Regulation in Medicine
- Electron Spin Resonance Studies
- Adipose Tissue and Metabolism
- Connexins and lens biology
- Cardiac Fibrosis and Remodeling
- Ion channel regulation and function
- Immune Response and Inflammation
- Gout, Hyperuricemia, Uric Acid
- Heart Rate Variability and Autonomic Control
- Biochemical effects in animals
- Cardiovascular Disease and Adiposity
- Cardiovascular Issues in Pregnancy
- Advanced MRI Techniques and Applications
- Selenium in Biological Systems
- Pregnancy and preeclampsia studies
- Organ Transplantation Techniques and Outcomes
UiT The Arctic University of Norway
2011-2022
University Medical Center
2017
University College London
2017
Université Claude Bernard Lyon 1
2017
Aarhus University Hospital
2017
University Medical Center Utrecht
2017
Institute of Medical Biology
1988-2004
National Institute on Aging
2004
University Hospital of North Norway
2004
Smerteklinikken
2003
Environmental stresses converge on the mitochondria that can trigger or inhibit cell death. Excitable, postmitotic cells, in response to sublethal noxious stress, engage mechanisms afford protection from subsequent insults. We show reoxygenation after prolonged hypoxia reduces reactive oxygen species (ROS) threshold for mitochondrial permeability transition (MPT) cardiomyocytes and survival is steeply negatively correlated with fraction of depolarized mitochondria. Cell exhibits a memory...
Myocardial protection in the rabbit induced by ischemic preconditioning is thought to be adenosine receptor linked, but signaling pathway responsible for has yet identified. This study tests whether protein kinase C could involved. Either of two inhibitors C, staurosporine (50 micrograms/kg) or polymyxin B (24 mg/kg), were administered rabbits subjected 30 min regional myocardial ischemia followed 180 reperfusion. Half preconditioned while other half served as nonpreconditioned controls....
Rabbits and rats are becoming popular models for in vitro as well situ studies of myocardial infarction. In the present analysis we evaluated results several our completed investigations tested whether blood-free perfusate, anesthesia, or risk zone size affects infarction these species. addition, influence method used determining infarct (histology histochemistry) was examined rabbits. All hearts experienced 30 min regional ischemia followed by either 2-3 h reperfusion animals which assessed...
To investigate the cardiac effects of enzymatically generated oxygen radicals isolated Langendorff rat heart preparations were perfused with hypoxanthine (0.96 mmol-litre−1) plus xanthine oxidase (0.025 U-ml−1). Oxygen produced an immediate increase in coronary flow. After 10 min a pronounced reduction contractile performance, as well concentrations high energy phosphates, was seen. Electron microscopical examination showed damage cellular oedema prominent finding. These all effectively...
Abstract: Melatonin has potent cardioprotective properties. These actions have been attributed to its free radical scavenging and anti‐oxidant actions, but may also be receptor mediated. exerts powerful anti‐adrenergic based on effects contractility of isolated papillary muscles. The aims this study were determine whether melatonin the perfused rat heart, mechanism thereof establish these contribute protection heart during ischaemia/reperfusion. results showed that (50 μ m ) caused a...
Aim: Gap junction intercellular communication (GJIC) and hemichannel permeability may have important roles during an ischemic insult. Our aim was to evaluate the effect of ischemia on gap channels hemichannels. Methods: We used neonatal rat heart myofibroblasts simulated with a HEPES buffer high potassium, low pH, absence glucose, oxygen tension reduced by dithionite. Microinjection, western blot, immunofluorescence, cell viability dye uptake were effects induced Isolated perfused hearts...
Elevated uric acid (UA) is associated with the presence of metabolic syndrome (MetS). In a prospective cohort study, we assessed whether baseline and longitudinal change in UA were risk factors for development MetS its individual components. We included 3087 women 2996 men who had measured population based Tromsø Study 1994–95. The participants stratified according to body mass index (BMI). Endpoints each component after 7 years, revised National Cholesterol Education Program's Adult...
Melatonin, the chief secretory product of pineal gland, has been shown to protect heart against ischemia-reperfusion injury. This was attributed its free radical scavenging and broad-spectrum antioxidant properties. The possibility that melatonin may act via receptor intracellular signaling, not yet addressed in this regard. In all previous studies, only acute effects on heart, were evaluated. aims present study to: (i) compare long-term infarct size functional recovery ischemic (ii)...
Environmental stresses converge on the mitochondria that can trigger or inhibit cell death. Excitable, postmitotic cells, in response to sublethal noxious stress, engage mechanisms afford protection from subsequent insults. We show reoxygenation after prolonged hypoxia reduces reactive oxygen species (ROS) threshold for mitochondrial permeability transition (MPT) cardiomyocytes and survival is steeply negatively correlated with fraction of depolarized mitochondria. Cell exhibits a memory...
This study was aimed at elucidating whether ventricular hypothermia-induced dysfunction persisting after rewarming the unsupported in situ dog heart could be characterized as a systolic, diastolic, or combined disturbance. Core temperature of 8 mongrel dogs gradually lowered to 25°C and returned 37°C over period 328 min. Systolic function described by maximum rate increase left (LV) pressure (dP/d t max ), relative segment shortening (SS%), stroke volume (SV), load-independent contractility...