A5072943935- Plant Disease Resistance and Genetics
- Chromosomal and Genetic Variations
- Wheat and Barley Genetics and Pathology
- Plant Pathogens and Fungal Diseases
- Plant-Microbe Interactions and Immunity
- Genomics and Phylogenetic Studies
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Mycorrhizal Fungi and Plant Interactions
- Genomic variations and chromosomal abnormalities
- Plant Virus Research Studies
- Mycotoxins in Agriculture and Food
- Nematode management and characterization studies
- CRISPR and Genetic Engineering
- Genetic diversity and population structure
ETH Zurich
2017-2023
University of Neuchâtel
2019-2023
Science for Life Laboratory
2022
Uppsala University
2021-2022
Integra (United States)
2018
Board of the Swiss Federal Institutes of Technology
2017
Transposable elements (TEs) are drivers of genome evolution and affect the expression landscape host genome. Stress is a major factor inducing TE activity; however, regulatory mechanisms underlying de-repression poorly understood. Plant pathogens excellent models to dissect impact stress on TEs. The process plant infection induces for pathogen, virulence factors (i.e., effectors) located in TE-rich regions become expressed. To dynamics contributions virulence, we analyzed four strains wheat...
Accurate, high-throughput phenotyping for quantitative traits is a limiting factor progress in plant breeding. We developed an automated image analysis to measure resistance septoria tritici blotch (STB), globally important wheat disease, enabling identification of small chromosome intervals containing plausible candidate genes STB resistance. 335 winter cultivars were included replicated field experiment that experienced natural epidemic development by highly diverse but fungicide-resistant...
Meiosis is one of the most conserved molecular processes in eukaryotes. The fidelity pairing and segregation homologous chromosomes has a major impact on proper transmission genetic information. Aberrant chromosomal can have phenotypic consequences, yet mechanisms are poorly understood. Fungi excellent models to investigate transmission, because many species highly polymorphic genomes that include accessory chromosomes. Inheritance often unstable losses little fitness. We analyzed...
Abstract Species harbor extensive structural variation underpinning recent adaptive evolution. However, the causality between genomic features and induction of new rearrangements is poorly established. Here, we analyze a global set telomere-to-telomere genome assemblies fungal pathogen wheat to establish nucleotide-level map variation. We show that emergence pesticide resistance has been disproportionally driven by rearrangements. use machine learning train model on events based 30...
Abstract Transposable elements (TEs) are drivers of genome evolution and affect the expression landscape host genome. Stress is a major factor inducing TE activity, however regulatory mechanisms underlying de-repression poorly understood. Key unresolved questions whether different types stress differentially induce activity TEs respond differently to same stress. Plant pathogens excellent models dissect impact on TEs, because lifestyle transitions off impose exposure variety conditions. We...
Accurate, high-throughput phenotyping for quantitative traits is the limiting factor progress in plant breeding. We developed automated image analysis to measure resistance septoria tritici blotch (STB), a globally important wheat disease, enabling identification of small chromosome intervals containing plausible candidate genes STB resistance. 335 winter cultivars were included replicated field experiment that experienced natural epidemic development by highly diverse but...
Abstract Genomic instability caused by chromosomal rearrangements has severe consequences for organismal fitness and progression of cancerous cell lines. The triggers destabilized chromosomes remain poorly understood but are often assumed to be associated with fragile sites. Here, we retrace a runaway degeneration process observed in fungal pathogen using telomere-to-telomere assemblies across an experimental pedigree. We show that the same sites triggered reproducible, large-scale through...
Abstract Meiosis is one of the most conserved molecular processes in eukaryotes. The fidelity pairing and segregation homologous chromosomes has a major impact on proper transmission genetic information. Aberrant chromosomal can have phenotypic consequences, yet mechanisms are poorly understood. Fungi excellent models to investigate transmission, because many species highly polymorphic genomes that include accessory chromosomes. Inheritance often unstable losses little fitness. We analyzed...
Species harbor extensive structural variation underpinning recent adaptive evolution and major disease phenotypes. Most sequence rearrangements are generated non-randomly along the genome through non-allelic recombination transposable element activity. However, causality between genomic features induction of new is poorly established. Here, we analyze a global set telomere-to-telomere assemblies fungal pathogen wheat to establish nucleotide-level map variation. We show that emergence...