A5077387757- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Hydrogels: synthesis, properties, applications
- Photodynamic Therapy Research Studies
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Nanoplatforms for cancer theranostics
- 3D Printing in Biomedical Research
- Botulinum Toxin and Related Neurological Disorders
- Bee Products Chemical Analysis
- Ocular Surface and Contact Lens
- Innovative Microfluidic and Catalytic Techniques Innovation
- Antifungal resistance and susceptibility
- Phytochemical compounds biological activities
- Microencapsulation and Drying Processes
- Essential Oils and Antimicrobial Activity
- Dermatology and Skin Diseases
- Ocular Infections and Treatments
- Microfluidic and Capillary Electrophoresis Applications
- Polymer Surface Interaction Studies
Universidade Estadual de Maringá
2015-2021
Pharmaceutical Biotechnology (Czechia)
2015
Children's National
2013-2014
Antibiotic-resistant microorganisms have become a global concern, and the search for alternative therapies is very important. Photodynamic therapy (PDT) consists of use nontoxic photosensitizer (PS), light, oxygen. This combination produces reactive oxygen species singlet oxygen, which can alter cellular structures. Methylene blue (MB) substance from phenothiazine class often used as PS. In this work, to facilitate PS contact within wounds, we Design Experiments 23 plus central point develop...
Microfluidic synthesis of small and nearly-monodisperse liposomes is used to investigate the size-dependent passive transdermal transport nanoscale lipid vesicles. While large with diameters above 105 nm are found be excluded from deeper skin layers past stratum corneum, primary barrier nanoparticle transport, mean between 31–41 exhibit significantly enhanced penetration. Furthermore, multicolor fluorescence imaging reveals that smaller pass rapidly through corneum without vesicle rupture....
This study describes the investigation about physicochemical behavior of methylene blue (Mb) addition to systems containing poloxamer 407 (Polox), Carbopol 934P (Carb), intended be locally used by photodynamic therapy. A factorial design 23 (plus center point) was analyze rheological, mucoadhesive and textural properties preparations. Systems lower concentrations Polox (15 17.5%, w/w) exhibited pseudoplastic flow low degrees rheopexy. On other hand, at higher concentration (20%, display...
Considering the antioxidant activity of Trichilia catigua extract (TCE), aim current study was to develop and characterize W/O/W multiple emulsions containing different vegetable oils as a platform deliver TCE. The displayed (IC50) 4.59 µg/mL total phenol content (TPC) 50.84%. Formulations were prepared by phase-inversion emulsification method analyzed for morphological appearance, pH, conductivity, droplet size distribution, active, rheological properties, in vitro release, skin permeation,...
In this work, the established technique for microfluidic synthesis of nanoscale liposomes tunable size has been exploited preclinical studies investigating ability small to passively cross through dermal layers transdermal drug delivery. Topical application therapeutics provides an avenue painless, noninvasive delivery molecules aimed at a range clinical conditions. Unlike traditional methods, which yield polydisperse too large traverse (typically >80 nm), method enables first investigation...
Hypericin (Hyp), a natural hydrophobic and photoactive pigment, methylene blue (MB), hydrophilic cationic dye, are utilized as photosensitizer (PS) for photodynamic therapy of cancer. Bioadhesive thermoresponsive polymeric systems can improve the drug availability by increasing contact time between system mucosa also controlling release. In this work, an accelerated physicochemical stability study binary composed poloxamer 407 (Polox) Carbopol 934 P (Carb) MB or Hyp release was performed....
Background: Methylene blue (MB) is a photosensitizer used in photodynamic therapy (PDT) to treat colorectal cancer tumors and leishmaniasis infection. The clinical efficacy of PDT using MB dependent on the physicochemical characteristics formulation. Bioadhesive thermoresponsive systems containing poloxamer 407 Carbopol 934P have been proposed as platforms for PDT. However, effect properties these not fully understood, particularly light availability. Objective: aim this study was...