A5047411293- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Avian ecology and behavior
- Cytomegalovirus and herpesvirus research
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Animal Vocal Communication and Behavior
- Acute Lymphoblastic Leukemia research
- Cutaneous lymphoproliferative disorders research
- Cancer Immunotherapy and Biomarkers
- Cardiac tumors and thrombi
- Autoimmune and Inflammatory Disorders Research
- T-cell and Retrovirus Studies
- IL-33, ST2, and ILC Pathways
- Peripheral Neuropathies and Disorders
- Eosinophilic Disorders and Syndromes
- Animal Behavior and Reproduction
- Acute Myeloid Leukemia Research
- PARP inhibition in cancer therapy
- Fish Ecology and Management Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Nagoya University
2024-2025
Kyoto University
2013-2025
IFOM
2024
Palmetto Hematology Oncology
2020
Kobe City Medical Center General Hospital
2010-2014
Saitama Medical University
2014
Osaka University
2008
The prognosis of patients with primary mediastinal large B-cell lymphoma has improved over recent years. However, the optimal treatment strategy including role radiotherapy remains unknown. We retrospectively analyzed clinical outcomes 345 newly diagnosed in Japan. With a median follow up 48 months, overall survival at four years for treated R-CHOP (n=187), CHOP (n=44), DA-EPOCH-R (n=9), 2nd- or 3rd-generation regimens, and chemotherapy followed by autologous stem cell transplantation were...
Lymphoma-associated hemophagocytic syndrome (LAHS) is a serious disorder, and its early diagnosis treatment with appropriate chemotherapy are very important. However, reliable markers for of LAHS have not been identified. We screened serum cytokines using newly introduced assay system, cytometric bead array (CBA), identified interferon-inducible protein 10 (IP-10)/CXCL10 monokine induced by interferon gamma (MIG)/CXCL9 as useful markers. Serum concentrations IP-10 MIG at the time were...
Background SLFN11 has recently been reported to execute cancer cells harboring replicative stress induced by DNA damaging agents. However, the roles of under physiological conditions remain poorly understood. Germinal center B-cells (GCBs) undergo somatic hypermutations and class-switch recombination, which can cause genotoxic stress. Hence, we tested whether expression needs be suppressed in GCBs during B-cell development. Objective To clarify profile different developmental stages...
Bacillus cereus is a growing concern as cause of life-threatening infections in patients with hematologic malignancies. However, the risk factors for unfavorable outcomes have not been fully elucidated. At our institution, we observed growth B. blood culture 68 (23) or without (45) malignancies treated from September 2002 to November 2009. We defined case having sepsis when more than two sets were positive only single set was absence other microorganisms who had definite infectious lesions....
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with poor prognosis. We encountered unique case of BPDCN that was leukemic at presentation without skin lesion and expressed CD33 antigen. A 74-year-old man admitted because dyspnea. Physically, hepatosplenomegaly, but not lesions superficial lymph node swelling, noted. The white blood count 33.6 × 10(9)/L 19% giant abnormal cells. These cells were positive for CD4, CD86, CD123 (bright), BDCA-2, HLA-DR,...
Abstract An inhibitor of the histone methyltransferase enhancer zeste homologue 2 (EZH2), tazemetostat, has been developed for treatment B‐cell lymphoma, but its mechanisms action are not fully elucidated. We screened genes targeted by tazemetostat in eleven lymphoma cell lines and found that significantly increased expression chemokine (C‐C motif) ligand 17 ( CCL17 )/thymus‐ activation‐regulated TARC ) all, which codes a is hallmark Hodgkin/Reed‐Sternberg (H/RS) cells Hodgkin lymphoma....
Abstract Primary central nervous system lymphoma ( PCNSL ) is a distinct subtype of extranodal with aggressive clinical course and poor outcome. As increased IL ‐10/ ‐6 ratio recognized in the cerebrospinal fluid CSF patients, we hypothesized that might originate from population B cells high ‐10‐producing capacity, an equivalent “regulatory cells” mice. We intended this study to clarify whether Tim‐1, molecule known as marker for regulatory mice, expressed . By immunohistochemical analysis,...
Like most seabirds Streaked Shearwaters Calonectris leucomelas have sexually monomorphic plumage. Researchers conveniently identified gender in the field by means of two types calls, associated with dimorphism body size. By molecular sexing analysis using chromo-helicase-DNA-binding (CHD) genes, we determined relation to call and We recorded type measured dimensions collected non-invasive samples (buccal cells or feathers) at breeding islands. As obvious amplification identify polymerase...
We assessed the prognostic impact of occult bone marrow involvement, determined by flow cytometry and/or polymerase chain reaction, in a population 117 consecutive patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL) treated rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). Twenty-four (20.5%) had morphologically 16 (13.7%) 77 (65.8%) no involvement. Although pretreatment characteristics negative or involvement group were similar, severe...
Activation-induced cytidine deaminase (AID) plays important roles in the development of diffuse large B-cell lymphoma (DLBCL); however, its prognostic value remains controversial. Here, we evaluated AID expression 71 DLBCL patients treated with R-CHOP by immunohistochemistry and investigated significance. was detected 40.8% samples associated IRF4 expression. Notably, correlated shorter progression-free survival overall for high (3–5) international index (IPI) score. Moreover, it a strong...
Streaked Shearwaters Calonectris leucomelas breed along the northwest Pacific coast, and winter in Australia Southeast Asia. Previous studies at nesting sites on islands off Japanese coast have indicated that males females give different mating calls. This research, implemented a breeding colony Kanmuri Island, Kyoto Prefecture, showed there were differences external measurements of giving low-pitch high-pitch vocalizations. A discriminant function:...
A 79-year-old man with a 2-month history of fever and weight loss was admitted to our hospital because an acute abdomen. Abdominal CT scans showed marked sectional thickening edema the small intestine. On laparotomy, 16-cm section intestine ischemic necrotic; therefore, segmentectomy performed. thrombus noted at stump mesenteric artery branch. Histopathological analysis resected revealed fibrin thrombi in both arteries veins. Furthermore, cluster large, abnormal lymphoid cells bordering...