Targeted thorium-227 conjugates (TTCs) represent a novel class of therapeutic radiopharmaceuticals for the treatment cancer. TTCs consist alpha particle emitter complexed to 3,2-hydroxypyridinone chelator conjugated tumor-targeting monoclonal antibody. The high energy and short range particles induce potent selective anti-tumor activity driven by induction DNA damage in target cell. Methods: efficacy human epidermal growth factor receptor 2 (HER2)-TTC was tested combination vitro vivo with...

A large-scale experimental study has been conducted at the Coriolis Rotating Platform to investigate dynamics of uni- and bi-directional exchange flows along a channel with trapezoidal cross section under influence background rotation. High-resolution two-dimensional particle image velocimetry micro-conductivity probes were used obtain detailed velocity fields density profiles flow generated across different parametric conditions. Experimental measurements give new insight into...

ABSTRACT The transition between the slope and basin floor is typically marked by a break, in some cases causing channels to terminate turbidity currents undergo loss of confinement. It thus essential understand how these breaks losses confinement influence hydrodynamic evolution impact their depositional variability within natural scale channel mouth settings. Flume experiments, utilizing Shields scaling, are conducted study angle (3°, 6° 9°) initial suspended sediment concentrations (12 18%...

Results are presented from a series of laboratory experiments investigating the characteristic features particle-laden, round, turbulent, buoyant jets discharged horizontally into stationary and coflowing receiving fluids. For volumetric source concentrations particles tested (∼ 0.1%), presence particle load was found to have no significant influence on mean jet trajectories. Deposition patterns bed water container indicated existence two separate sedimentation processes for discharges or...

Results are presented from laboratory studies investigating the behavior of fine sand particles within turbulent open channel flow conditions flowing over rough, porous beds. A particle tracking technique was employed to record and analyze motion flow, while mean fluctuating velocities were measured by an acoustic Doppler velocimeter probe. Measured settling rates show a strong influence turbulence, being generally enhanced in near-bed intermediate regions retarded outer region, compared...

To optimize the electrical characteristics of polysilicon emitter bipolar transistors, poly interface needs careful engineering. In this paper, transistors a 0.5 /spl mu/m BiCMOS process have been fabricated with intentionally grown oxides in an LPCVD cluster for precise control over interfacial oxide thickness and uniformity. The trade off between current gain enhancement increased 1/f noise will be discussed various thicknesses annealing conditions. It demonstrated that sufficiently large...

A new bipolar process technology for fabricating self-aligned transistors with polysilicon contacted emitters is described. The extrinsic base regions of the transistor are to emitter contact by exploiting effects concentration-dependent oxidation selectively oxidize polysilicon. shallow fabricated a thin oxide layer at polysilicon-silicon interface, thereby enhancing efficiency and thus current gain device. It demonstrated that this enhancement can be traded considerable increase in active...

AbstractDetailed velocity and density measurements are used to investigate dense water dynamics in an inclined, silled channel of triangular cross-section with varying side slope α adverse bed φ. For the steeper configuration considered (φ=3.6°), dense-water bottom current is shown be frictionally-controlled, internal flow structure characterized by a sharp pycnocline decreasing isopycnal separation along-channel direction. milder up-sloping (φ=1.7°), outflow hydraulically-controlled as sill...

Abstract Flume experiments are conducted to investigate the intrinsic links between time‐varying bed load transport properties for uniform sediments and surface morphology under unsteady hydrograph flows, in absence of upstream sediment supply. These conditions representative regulated river reaches (e.g., downstream a dam) that subject natural flood discharges or managed water releases, resulting net degradation bed. The results demonstrate magnitude unsteadiness have significant impacts on...

Estuaries and tidal inlets are often characterised by the presence of both cohesive non-cohesive sediments. Knowledge sedimentation behaviour sand-mud mixtures is therefore crucial to understanding prediction time-dependent structure (i.e. mixed or segregated), composition erodibility sediment bed deposits developing within these environments. In current study, a series settling column tests conducted investigate hindered initial consolidation phases range sand-clay determine parametric...

Cage-based aquaculture has been growing rapidly in recent years. In some locations, cage-based resulted the clustering of large quantities cages fish farms located inland lakes or reservoirs and coastal embayments fjords, significantly affecting flow mass transport surrounding waters. Existing studies have focused primarily on macro-scale blockage effects cages, complex wake associated near-field presence remain largely unclear. As a first step toward resolving this knowledge gap, study...

Laboratory and computational fluid dynamics (CFD) model studies with turbulent, plane, particle-laden buoyant jets discharged horizontally into a quiescent ambient have demonstrated that the presence of particles has no significant influence upon jet trajectories over wide range forcing conditions source concentrations 0.1% or less. Bed deposition distributions show large initial maximum close to source, indicative dominant, localized particle fall-out from margins. Beyond this near-source...

Abstract The overflow of dense water from the Nordic Seas through Faroese Channel system was investigated combined laboratory experiments and numerical simulations using Massachusetts Institute Technology General Circulation Model. In experimental study, a scaled, topographic representation Faroe-Shetland Channel, Wyville-Thomson Basin Ridge Faroe Bank seabed bathymetry constructed mounted in rotating tank. A series parametric conducted dye-tracing drogue-tracking techniques to investigate...

In this paper, we investigate the tradeoff between enhanced gain and base doping for polysilicon emitter bipolar transistors fabricated with an intentional oxide layer at polysilicion-silicon interface. To assist in our investigation, have a range of type identical processing apart from boron implant active base. The results detailed electrical measurements on these devices are presented, it is demonstrated that can be traded considerable reduction resistance and, hence, potential...

Silicon bipolar transistors have been made with arsenic-implanted or phosphorus-diffused polysilicon emitters. The effects of different surface treatments, prior to deposition, are investigated by comparing results obtained for a dip etch in hydrofluoric acid those an RCA clean. Detailed electrical presented these two types device, including transistor characteristics as function temperature. Rutherford backscattering is used provide the arsenic profiles and single-crystal silicon. It shown...

Soil erosion and deposition mechanisms play a crucial role in the sustainability of both existing reservoirs newly planned projects. is one most important factors influencing sediment transport yields, and, context reservoirs, surrounding watersheds supply runoff yield to receiving water body. Therefore, appropriate land management strategies are needed minimize influence yields on reservoir volume hence, capacity power generation. In this context, soil control measures such as buffer strips...