A5089133908- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Mosquito-borne diseases and control
- Studies on Chitinases and Chitosanases
- Digestive system and related health
- Pediatric health and respiratory diseases
- Dermatology and Skin Diseases
- Autophagy in Disease and Therapy
- Allergic Rhinitis and Sensitization
- Invertebrate Immune Response Mechanisms
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Diet and metabolism studies
- NF-κB Signaling Pathways
Institute of Biomedical Sciences, Academia Sinica
2018-2023
National Yang Ming Chiao Tung University
2018
Institute of Molecular Biology, Academia Sinica
2018
University of Malaya
2013-2015
Abstract Background Respiratory syncytial virus (RSV) infection is epidemiologically linked to asthma. During RSV infection, IL‐33 elevated and promotes immune cell activation, leading the development of However, which cells are responsible for triggering airway hyperreactivity (AHR), inflammation eosinophilia remained be clarified. We aimed elucidate individual roles IL‐33‐activated innate cells, including ILC2s ST2 + myeloid in infection‐triggered pathophysiology. Methods The role...
Background Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus that has caused multiple unprecedented and re-emerging outbreaks in both tropical temperate countries. Despite ongoing research efforts, the underlying factors involved facilitating CHIKV replication during early infection remains ill-characterized. The present study serves to identify host proteins modulated response using a proteomics approach. Methodology Principal Findings whole cell proteome profiles of...
Ketone bodies are increasingly understood to have regulatory effects on immune cell function, with β-hydroxybutyrate (BHB) exerting a predominantly anti-inflammatory response. Dietary strategies increase endogenous ketone body availability such as the ketogenic diet (KD) recently been shown alleviate inflammation of respiratory tract. However, role BHB has not addressed. Here, we observe that suppresses group 2 innate lymphoid (ILC2)-mediated airway inflammation. Central this mast cells,...
Although air pollutants such as fine particulate matter (PM2.5) are associated with acute and chronic lung inflammation, the etiology of PM2.5-induced airway inflammation remains poorly understood. Here we report that PM2.5 triggered hyperreactivity (AHR) neutrophilic concomitant increases in Th1 Th17 responses epithelial cell apoptosis. We found γδ T cells promoted AHR through IL-17A. Unexpectedly, invariant natural killer (iNKT) played a protective role pulmonary inflammation....
The Chikungunya virus (CHIKV) is an arthropod borne virus. In the last 50 years, it has been cause of numerous outbreaks in tropical and temperate regions, worldwide. There limited understanding regarding underlying molecular mechanisms involved CHIKV replication how interacts with its host. present study, comparative proteomics was used to identify secreted host proteins that changed abundance response early infection. Two-dimensional gel electrophoresis analyse compare secretome profiles...
Invariant natural killer T (iNKT) cells, which are activated by cell receptor (TCR)-dependent recognition of lipid-based antigens presented the CD1d molecule, have been shown to participate in pathogenesis many diseases, including asthma and liver injury. Previous studies inhibition iNKT activation using lipid antagonists can attenuate cell-induced disease pathogenesis. Hence, development cell-targeted glycolipids facilitate discovery new therapeutics. In this study, we synthesized evaluated...