A5004599360- Asthma and respiratory diseases
- Ion Channels and Receptors
- Respiratory and Cough-Related Research
- Neuropeptides and Animal Physiology
- Olfactory and Sensory Function Studies
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Medicinal Plants and Neuroprotection
- Neurobiology and Insect Physiology Research
- Cancer Immunotherapy and Biomarkers
- Phytochemicals and Antioxidant Activities
- Cystic Fibrosis Research Advances
- Dermatology and Skin Diseases
- Pediatric health and respiratory diseases
- Genetics, Aging, and Longevity in Model Organisms
- Stress Responses and Cortisol
- Immune Cell Function and Interaction
Université de Montréal
2020-2024
Centre for Interdisciplinary Research in Rehabilitation
2023
Institute of Biomedical Sciences, Academia Sinica
2022
National Taiwan University
2013
Nociceptors, the high-threshold primary sensory neurons that trigger pain, interact with immune cells in periphery to modulate innate responses. Whether they also participate adaptive and humoral immunity is, however, not known. In this study, we probed if nociceptors have a role distinct airway skin models of allergic inflammation. both models, genetic ablation pharmacological silencing substantially reduced inflammatory cell infiltration affected tissue. Moreover, found profound specific...
ABSTRACT Vagal sensory neurons convey sensations from internal organs along the vagus nerve to brainstem. Pruriceptors are a subtype of that transmit itch and induce pruritus. Despite extensive research on molecular mechanisms itch, studies focusing pruriceptors in vagal ganglia still need be explored. In this study, we characterized pruriceptor by their responsiveness pruritogens such as lysophosphatidic acid, β -alanine, chloroquine, cytokine oncostatin M. We discovered lung-resident...
Although air pollutants such as fine particulate matter (PM2.5) are associated with acute and chronic lung inflammation, the etiology of PM2.5-induced airway inflammation remains poorly understood. Here we report that PM2.5 triggered hyperreactivity (AHR) neutrophilic concomitant increases in Th1 Th17 responses epithelial cell apoptosis. We found γδ T cells promoted AHR through IL-17A. Unexpectedly, invariant natural killer (iNKT) played a protective role pulmonary inflammation....
Nociceptor neurons play a crucial role in maintaining the body's homeostasis by detecting and responding to potential dangers environment. However, this function can be detrimental during allergic reactions, since vagal nociceptors contribute immune cell infiltration, bronchial hypersensitivity, mucus imbalance, addition causing pain coughing. Despite this, specific mechanisms which acquire pro-inflammatory characteristics reactions are not yet fully understood. In study, we aimed...