A5056435724- Neuropeptides and Animal Physiology
- Cancer, Stress, Anesthesia, and Immune Response
- Asthma and respiratory diseases
- Heavy Metal Exposure and Toxicity
- Pain Mechanisms and Treatments
- Ion Channels and Receptors
- Trace Elements in Health
- Metabolism and Genetic Disorders
- Birth, Development, and Health
- Extracellular vesicles in disease
- Environmental Toxicology and Ecotoxicology
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Regulation of Appetite and Obesity
- Ion Transport and Channel Regulation
- Aluminum toxicity and tolerance in plants and animals
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Indigenous Health and Education
- Alcohol Consumption and Health Effects
- Transcranial Magnetic Stimulation Studies
- Coffee research and impacts
- Aldose Reductase and Taurine
- Occupational Health and Burnout
- Zebrafish Biomedical Research Applications
- Dye analysis and toxicity
Karolinska Institutet
2023-2024
Universidade Federal de Santa Catarina
2019-2024
Queen's University
2023-2024
Children's Hospital of Orange County
2023-2024
Université de Montréal
2020-2022
Universidade do Oeste de Santa Catarina
2017-2022
Abstract Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory peripheral nervous systems 1–5 . Whether neo-innervation of pain-initiating neurons affects cancer immunosurveillance remains unclear. Here we show melanoma cells interact with nociceptor neurons, leading to increases in their neurite outgrowth, responsiveness noxious ligands neuropeptide release. Calcitonin gene-related peptide (CGRP)—one such nociceptor-produced neuropeptide—directly exhaustion...
The molecular and functional contributions of intratumoral nerves to disease remain largely unknown. We localized synaptic markers within tumors suggesting that these form connections. Consistent with this, electrophysiological analysis shows malignancies harbor significantly higher electrical activity than benign or normal tissues. also demonstrate pharmacologic silencing tumoral activity. Tumors implanted in transgenic animals lacking nociceptor neurons show reduced These data suggest at...
Evidence has shown that caffeine administration reduces pro-inflammatory biomarkers, delaying fatigue and improving endurance performance. This study examined the effects of on expression inflammatory-, adenosine receptor- (the targets caffeine), epigenetic-, oxidative metabolism-linked genes in vastus lateralis muscle mice submitted to lipopolysaccharide (LPS)-induced inflammation. We showed pre-treatment before LPS reduced Il1b, Il6, Tnfa, increased Il10 Il13. The negative modulation...
Evolution has created complex mechanisms to sense environmental danger and protect tissues, with the nervous immune systems playing pivotal roles. These work together, coordinating local systemic reflexes restore homeostasis in response tissue injury infection. By sharing receptors ligands, they influence pathogenesis of various diseases. Recently, a less-explored aspect neuroimmune communication emerged: release neuropeptides from cells cytokines/chemokines sensory neurons. This article...
ABSTRACT Patients with densely innervated tumors do poorly as compared to those sparsely disease. Why some heavily recruit nerves while others not, remains unknown does the functional contribution of tumor-infiltrating cancer. Moreover, patients receive chemotherapeutic treatment, whether these drugs affect nerve recruitment has not been tested. Using a murine model ovarian cancer, we show that sensory potentiate tumor growth, decrease survival, and contribute treatment resistance....
Abstract Cancer is the top cause of death in USA, responsible for 30% deaths. A cure remains undiscovered. Therapy effectiveness varies by patient and tumor type can have negative side effects. The immune system, designed to eliminate abnormal cells, including cancer often impaired. For example, skin cancer, extended activation certain receptors exhaust reducing their cancer-fighting ability. Our lab found that cells trigger nociceptor neurons tumors, leading neuropeptide release exhausts...
<title>Abstract</title> <bold>Objective: </bold>This study aimed to examine the impact of high-fat diet (HFD)-induced obesity on pain sensitivity and tetrahydrobiopterin (BH4) levels. The effect moderate-intensity physical exercise, an anti-inflammatory non-pharmacological intervention, scores was also investigated. <bold>Methods:</bold> Adult male C57BL/J6 mice were fed standard or HFD for eight weeks. Total body weight, food intake, locomotor motivational behavior reflexes measured. A...
Nociceptor neurons impact tumor immunity. Removing nociceptor reduced myeloid-derived suppressor cell (MDSCs) infiltration in mouse models of head and neck carcinoma melanoma. Carcinoma-released small extracellular vesicles (sEVs) attract nociceptive nerves to tumors. sEV-deficient tumors fail develop mice lacking neurons. Exposure dorsal root ganglia (DRG) cancer sEVs elevated expression Substance P, IL-6 injury-related neuronal markers while treatment with cytotoxic CD8 T-cells induced an...
Resumo Objetivo: socializar as estratégias desenvolvidas pela Comissão Intersetorial de Saúde do Trabalhador e da Trabalhadora (CISTT) município Joaçaba/SC, Brasil, entre os anos 2012 2017. Métodos: relato experiência com base em levantamento análise documental atas relatórios CISTT, matérias jornalísticas sites instituições públicas sindicatos. Resultados: diálogos interação a comunidade respeito tema saúde trabalhador (ST) por meio promoção seminários temáticos sobre trabalho saúde,...