A5007179372- Zebrafish Biomedical Research Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Environmental Toxicology and Ecotoxicology
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Vitamin C and Antioxidants Research
- Phytochemicals and Antioxidant Activities
- Aquaculture disease management and microbiota
- Metabolomics and Mass Spectrometry Studies
- Eicosanoids and Hypertension Pharmacology
- Natural Antidiabetic Agents Studies
- Nitric Oxide and Endothelin Effects
- Peroxisome Proliferator-Activated Receptors
- Glutathione Transferases and Polymorphisms
- Antioxidant Activity and Oxidative Stress
- Aldose Reductase and Taurine
- Neuroendocrine regulation and behavior
- Cynara cardunculus studies
- Pesticide and Herbicide Environmental Studies
- Sulfur Compounds in Biology
- Microplastics and Plastic Pollution
- Free Radicals and Antioxidants
- Receptor Mechanisms and Signaling
- Curcumin's Biomedical Applications
Universidade Federal do Rio Grande do Sul
2018-2024
Tallinn University of Technology
2023-2024
Competence Centre on Health Technologies (Estonia)
2023-2024
Community University of Chapecó Region - Unochapecó
2015-2023
Brazilian National Association of Graduate Programs in Communication
2022
University of Rio Grande and Rio Grande Community College
2020
Universidade Federal de Santa Catarina
2020
The enriched environment (EE) is a laboratory housing model that emerged from efforts to minimize the impact of environmental conditions on animals. Recently, we showed EE promoted positive effects behavior and cortisol levels in zebrafish submitted unpredictable chronic stress (UCS) protocol. Here, expanded characterization UCS protocol by assessing parameters oxidative status brain reveal protects against induced stress.Zebrafish were exposed (21 or 28 days) standard subjected for seven...
Cynara scolymus L., Asteraceae, are traditionally used to treat dyspepsia. This study evaluated the hypolipidemic and antiatherogenic effects of an aqueous extract prepared from leaves C. in rat's model. Hypercholesterolemic rats (1% cholesterol 0.5% cholic acid for 15 days) were treated (0.5 ml/200 g) with (150, 300, or 600 mg/kg p.o.; n = 6) simvastatin (4 once per day 30 days along hypercaloric diet. A control group (C) was given water g; 6). high-cholesterol diet maintained throughout...
The occurrence of ractopamine (RAC) hydrochloride in water bodies is significant concern due to its ecological impacts and toxicity humans. RAC a β-adrenergic agonist drug used as feed additive (1) improve efficiency, (2) rate weight gain, (3) increase carcass leanness animals raised for their meat. This excreted by urine introduced into the environment affecting nontarget organisms including fish. In wastewater released from farms, concentrations were detected 0.124 µg/L 30.1 µg/L, levels...
Zebrafish are increasingly used as a model animal in neuroscience research. Here we describe our protocol to quantify thiobarbituric acid reactive species (TBARS) zebrafish brain tissue. TBARS levels indicative of lipid peroxidation.
The jaboticaba tree, Plinia trunciflora (O. Berg) Kausel, is popularly named “jabuticabeira” in Brazil and used folk medicine to treat diabetes chronic inflammation of the tonsils, but studies evaluating central effects this species are limited. This study evaluated antidepressant-like antioxidant P. (PT) aqueous extract, which five different anthocyanins were identified. PT showed significant ferric-reduction power DPPH radical scavenging activity vitro reduced lipid peroxidation both ex...
Abstract Schizophrenia pathophysiology has been associated with dopaminergic hyperactivity, NMDA receptor hypofunction, and redox dysregulation. Most behavioral assays animal models to study this condition were developed in rodents, leaving room for species‐specific biases that could be avoided by cross‐species approaches. As MK‐801 amphetamine are largely used mice rats mimic schizophrenia features, aimed compare the effects of these drugs several zebrafish ( Danio rerio ) assays. Male...
Solidago chilensis Meyen, Asteraceae, is traditionally used to treat inflammation. However, phytochemical and pharmacology investigations are lacking. This study evaluated the hypoglycemic hypolipidemic effects of hydroalcoholic extract from S. aerial parts in rats. In oral glucose tolerance tests rats received saline (0.5 ml/100 g) control group (C), (125, 250 or 500 mg/kg p.o.; n = 6) glibenclamide (10 6). After 30 min, (4 g/kg) was administered. Rats treated with demonstrated decreased...
Agriculture has gained increasing importance in response to the continuous growth of world population and constant need for food. To avoid production losses, farmers commonly use pesticides. Mancozeb is a fungicide used agriculture as this compound effective combating fungi that harm crops. However, may also produce damage non-target organisms present soil water. Therefore, study aimed investigate influence exposure mancozeb on survival rate, locomotor activity, behavior, oxidative status...
Celtis iguanaea (Jacq.) Sarg., Cannabaceae, is popularly used in the treatment of diabetes mellitus. However, chemical and pharmacological investigations are lacking. In this study, we investigated effects hydroalcoholic extract from C. on markers cardiovascular diseases glucose metabolism cholesterol-fed rats. Therefore, hypercholesterolemic rats (1% cholesterol) were orally treated with (C-150, CI-300, or CI-600 mg/kg) simvastatin (4 (n = 6) once a day (30 days) diet. A control group (C)...
Zebrafish are incresingly used as a model animal in neuroscience research. Here we describe protocol to quantify the total amount of proteins zebrafish brain tissue.
Zebrafish are increasingly used as a model animal in neuroscience research. Here we describe our protocol to collect and process zebrafish brains so they well presearved viable for biochemical assays.
Zebrafish are incresingly used as a model animal in neuroscience research. Here we describe protocol to quantify nonprotein sulfhydryl groups (NPSH), an indirect evaluation of the levels reduced glutathione (GSH), major oxidative stress defense central nervous system.
Recycled polyvinyl chloride (PVC) microplastics have been detected in the aquatic environment. These recycled microparticles contain chemicals that are released into environment reaching different organisms. Although problem of presence PVC is evident, toxicological consequences this contaminant to exposed organisms remains be better determined. The aim study was investigate toxicity attributed exposure environmentally relevant concentrations adult zebrafish (Danio rerio). experimental...