A5077381773- Obesity, Physical Activity, Diet
- Neuropeptides and Animal Physiology
- Cancer, Stress, Anesthesia, and Immune Response
- Olfactory and Sensory Function Studies
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Physical Activity and Health
- Circadian rhythm and melatonin
- Health disparities and outcomes
- Aortic aneurysm repair treatments
- Pain Mechanisms and Treatments
- RNA modifications and cancer
- Cardiac Valve Diseases and Treatments
- Health and Lifestyle Studies
- S100 Proteins and Annexins
- Alzheimer's disease research and treatments
- Child Nutrition and Water Access
- Single-cell and spatial transcriptomics
- Neurobiology and Insect Physiology Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Stress Responses and Cortisol
- Hippo pathway signaling and YAP/TAZ
- Impact of Light on Environment and Health
- Nerve injury and regeneration
- Pluripotent Stem Cells Research
Guangdong Ocean University
2025
Pennsylvania State University
2022-2025
China Southern Power Grid (China)
2024
Zhejiang University
2023-2024
City University of Hong Kong
2024
Guangxi University
2023
University of Chinese Academy of Sciences
2023
Children's Hospital of Zhejiang University
2023
Second Affiliated Hospital of Zhejiang University
2023
Shanghai Jiao Tong University
2022-2023
Abstract Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory peripheral nervous systems 1–5 . Whether neo-innervation of pain-initiating neurons affects cancer immunosurveillance remains unclear. Here we show melanoma cells interact with nociceptor neurons, leading to increases in their neurite outgrowth, responsiveness noxious ligands neuropeptide release. Calcitonin gene-related peptide (CGRP)—one such nociceptor-produced neuropeptide—directly exhaustion...
Abstract Expression of mRNA for the neutrophil (PMN) chemokine, KC, in rat models lung injury suggests a role this chemokine pulmonary inflammation. We addressed hypothesis at protein level by functionally characterizing recombinant KC (rKC) vitro and vivo. In vitro, rKC induced PMN chemotaxis increased expression CD11b/CD18 on PMNs. Recombinant also respiratory burst (quantitated flow cytometry) PMNs, similar to that caused its human structural homologue, gro/melanoma growth-stimulating...
Urbanization induced changes have attracted widespread attention. Key challenges arise from the inherent uncertainties in attribution models diagnosing driving mechanisms and interrelationships of attributes given by complexity interactions within a city. Here, we investigate urbanization dynamics nighttime light signals before analyzing their 2014 to 2020 on both provincial regional scale flat versus mountainous comparison. Model are discussed comparing contribution results Geodetector Gini...
Anatomical congruence of peripheral nerves and blood vessels is well recognized in a variety tissues. Their physical proximity similar branching patterns suggest that the development these networks might be coordinated process. Here we show large diameter coronary veins serve as an intermediate template for distal sympathetic axon extension subepicardial layer dorsal ventricular wall developing mouse heart. Vascular smooth muscle cells (VSMCs) associate with during angiogenesis. In vivo...
Androgen-Driven Sequestration Male and female mice differ in the neuronal patterns that serve mammary glands. Yin Liu et al. (p. 1357 ) now describe how gonadal hormones drive development of distinct male sensory innervations. Although both glands develop their innervation similarly early embryogenesis, once androgens take effect, developmental trajectories diverge. By birth, rich network neurons present is absent male. Androgens cause a switch from expression full-length neurotrophin...
The excellent properties exhibited by W/Cu composites have stimulated the interest of many researchers. Molecular dynamics (MD) plays an important role in regulating alloy ratio and exploring microscopic mechanism. accuracy MD simulation depends on reliability potential function. Here, we report a new n-body potential. Compared with several existing potentials, present can describe more precisely lattice constant, cohesive energy elastic constants (C11, C12 C44) W3Cu. On basis developed...
Abstract A cell’s phenotype and function are influenced by dynamic interactions with its microenvironment. To examine cellular spatiotemporal activity, we developed SPACECAT—Spatially PhotoActivatable Color Encoded Cell Address Tags—to annotate, track, isolate cells while preserving viability. In SPACECAT, samples stained photocaged fluorescent molecules, labeled uncaging those molecules user-patterned near-UV light. SPACECAT offers single-cell precision temporal stability across diverse...
Sulfamethoxazole (SMX), a commonly used sulfonamide antibiotic, poses threat to aquatic life due its widespread presence in the environment. This study aims investigate specific effects of SMX on development marine medaka (Oryzias melastigma) embryos and larvae. Marine were exposed at concentrations 0 (solvent control group, SC group), 1 μg/L (low concentration L 60 (middle M 1000 (high H group). The results indicated that exposure significantly accelerated heart rate (p < 0.0001)...
Introduction Several US states have implemented regulations, including e-cigarette taxes, primarily to reduce use among youth and young adults. Although several studies examined tax assessing the impact of taxes on transitions tobacco/nicotine patterns are largely absent from extant literature. Methods We included 9774 participants aged 12–17 years at baseline waves 1 4 Population Assessment Tobacco Health Study. estimated transition probabilities between non-current users,...
Abstract Background Galangin has been extensively studied as the antitumor agent in various cancers. However, effect of galangin hepatocellular carcinoma (HCC) remains elusive. Methods Using RNA sequencing, differential expression lncRNA human HCC cell line with highly metastatic potential (MHCC97H) cells treated was investigated. Furthermore, H19 pattern also determined MHCC97H following treatment galangin. In addition, knockdown and overexpression performed to analyze on apoptosis, cycle,...
Spinal muscular atrophy (SMA) can cause multiple system dysfunction, especially lipid metabolic disorders, for which management strategies are currently lacking. Microbes related to metabolism and the pathogenesis of neurological diseases. This study aimed preliminarily explore alterations in gut microbiota SMA potential relationship between altered disorders. Fifteen patients with 17 gender- age-matched healthy controls were enrolled study. Feces fasting plasma samples collected. 16S...
Physical inactivity and mental health disorders are emerging threats to public in China. Previous research on links between exercise wellbeing have focused clinical populations, with little evidence from the general population, particularly younger adults. We aimed investigate associations physical fitness Chinese college students.
The generation of diverse neuronal subtypes involves specification neural progenitors and, subsequently, postmitotic differentiation, a relatively poorly understood process. Here, we describe mechanism whereby the neurotrophic factor NGF and transcription Runx1 coordinate differentiation nonpeptidergic nociceptors, major nociceptor subtype. We show that integrity Runx1/CBFβ holocomplex is crucial for NGF-dependent maturation. signals through ERK/MAPK pathway to promote expression Cbfb but...
m6A is one of the most common and abundant modifications RNA molecules present in eukaryotes. The methyltransferase complex, consisting methyltransferase-like 3 (METTL3), METTL14, WTAP, responsible for modification RNA. WTAP was identified as an mRNA splicing regulator. Its role a regulatory subunit complex embryonic development remains largely unknown. To investigate porcine early development, si-WTAP microinjected into parthenogenetic zygotes. knockdown significantly reduced blastocyst...
Introduction: Methoxychlor (MXC) is an organochlorine pesticide (OCP) that was formerly used worldwide as insecticide against pests and mosquitoes. However, MXC not biodegradable has lipophilic characteristics; thus, it accumulates in organisms affects reproductive function. MXC, estrogenic compound, promotes oxidative stress, induces stress damage to ovarian follicles, causes miscarriages stillbirths females. In this research endeavor, our primary objective explore the ramifications of...
Oxidative stress negatively affects the in vitro maturation (IVM) of oocytes. Procyanidin B1 (PB1) is a natural polyphenolic compound that has antioxidant properties. In this study, we investigated effect PB1 supplementation during IVM porcine Treatment with 100 μM significantly increased MII oocytes rate (p <0.05), parthenogenetic (PA) blastocyst <0.01) and total cell number PA < 0.01) which were cultured regular culture (IVC) medium. The activated IVC medium supplemented 150 compared...