A5102000562- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Venous Thromboembolism Diagnosis and Management
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Acute Myocardial Infarction Research
- Esophageal and GI Pathology
- Apelin-related biomedical research
- Signaling Pathways in Disease
- Reproductive Biology and Fertility
- Phagocytosis and Immune Regulation
- Brain Metastases and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Glutathione Transferases and Polymorphisms
- Lung Cancer Treatments and Mutations
- Pluripotent Stem Cells Research
- Autophagy in Disease and Therapy
- Cancer Risks and Factors
- Esophageal Cancer Research and Treatment
- Acute Ischemic Stroke Management
- Medicinal Plants and Bioactive Compounds
- Peptidase Inhibition and Analysis
- Vascular Procedures and Complications
Shandong First Medical University
2024
China Medical University
2024
Jilin University
2019-2024
Shandong Tumor Hospital
2024
Suzhou Traditional Chinese Medicine Hospital
2023-2024
Nanjing University of Chinese Medicine
2023-2024
Weifang Medical University
2024
Chongqing Medical University
2016
University of Auckland
2016
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016
Context Ferroptosis may play an essential role in lipid peroxidation and endothelial dysfunction of aortic cells (ECs) type 2 diabetes mellitus (T2DM) with atherosclerosis (AS). Hydroxysafflor yellow A (HSYA) has shown substantial antioxidant stress anti-ferroptosis.Objective This study confirms whether HSYA improves symptoms a mouse model T2DM/AS elucidates the underlying mechanisms.Materials methods ApoE-/- mice were fed high fat combined 30 mg/kg streptozotocin to establish model. Then...
Background: Preeclampsia is known to be associated with reduced circulating levels of estrogen. The effects estrogen in preeclampsia are normally mediated by the classical receptors. Intriguingly, a novel receptor, G protein-coupled receptor 30 (GPR30), has been recently found play an important role several estrogenic effects. However, mechanisms which GPR30 may mediate development remain unknown. Method: We observed that expression placental trophoblast cells lower preeclamptic placentas...
Background: Neoadjuvant chemoradiotherapy combined with immunotherapy (NICRT) is a new neoadjuvant treatment approach that has raised concerns regarding potential challenges in surgery and postoperative complications. This study aimed to compare the efficacy safety of (NCRT) NICRT for resectable locally advanced esophageal squamous cell carcinoma (ESCC). Methods: We retrospectively analyzed 291 patients ESCC who underwent therapy esophagectomy at three centers between January 2019 September...
Parthenogenetically activated oocytes cannot develop to term in mammals owing abnormal epigenetic modifications. Methylation of the N6 position adenosine (m6A) is a post-transcriptional modification RNA. To investigate role m6A methylation parthenogenetic (PA) embryonic development, we analyzed METTL3, METTL14, FTO, ALKBH5, YTHDF2, IGF2BP1, and IGF2BP2 expression by quantitative real-time PCR. These genes were found dynamically expressed during 2-cell, 4-cell, 8-cell, blastocyst stages...
Salidroside (Sal) possesses several pharmacological activities, such as antiaging, and anti-inflammatory, antioxidant, anticancer proliferation-promoting but the effects of Sal on oocytes have rarely been reported. In present study, we evaluated beneficial Sal, which is mainly found in roots Rhodiola. Porcine cumulus oocyte complexes were cultured IVM medium supplemented (with 250 μmol/L) with or not Sal. The maturation rate group increased from 88.34 ± 4.32% to 94.12 2.29%, blastocyst 30.35...
Introduction: Methoxychlor (MXC) is an organochlorine pesticide (OCP) that was formerly used worldwide as insecticide against pests and mosquitoes. However, MXC not biodegradable has lipophilic characteristics; thus, it accumulates in organisms affects reproductive function. MXC, estrogenic compound, promotes oxidative stress, induces stress damage to ovarian follicles, causes miscarriages stillbirths females. In this research endeavor, our primary objective explore the ramifications of...
Coexistence of pulmonary embolism (PE) and arterial thrombosis in a single patient is rare. Management such cases challenging because there no unified standard on how to treat this type disease. We herein report case involving 73-year-old man who was admitted the hospital 2-day history chest tightness. Pulmonary computed tomography angiography revealed filling defect main artery bilateral branches as well left subclavian embolism. AngioJet mechanical thrombectomy (Boston Scientific,...
Large Language Models (LLMs), despite their impressive performance on a wide range of tasks, require significant GPU memory and consume substantial computational resources. In addition to model weights, the occupied by KV cache increases linearly with sequence length, becoming main bottleneck for inference. this paper, we introduce novel approach optimizing which significantly reduces its footprint. Through comprehensive investigation, find that LLaMA2 series models, (i) similarity between...