A5003998528- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Endoplasmic Reticulum Stress and Disease
- Toxin Mechanisms and Immunotoxins
- Cytokine Signaling Pathways and Interactions
- Eosinophilic Esophagitis
- Inflammatory mediators and NSAID effects
- S100 Proteins and Annexins
- Inflammasome and immune disorders
- T-cell and Retrovirus Studies
- Computational Drug Discovery Methods
- Transgenic Plants and Applications
- Epigenetics and DNA Methylation
Washington University in St. Louis
2023
Gladstone Institutes
2012-2018
University of California, San Francisco
2012-2018
Institute of Virology of the Slovak Academy of Sciences
2015-2018
The balance of effector and regulatory T cell function, dependent on multiple signals epigenetic regulators, is critical to immune self-tolerance. Dysregulation helper 17 (Th17) cells associated with autoimmune diseases, including sclerosis. Here, we report that Sirtuin 1 (SIRT1), a protein deacetylase previously reported have an antiinflammatory in fact promotes autoimmunity by deacetylating RORγt, the signature transcription factor Th17 cells. SIRT1 increases RORγt transcriptional...
Salicylate and acetylsalicylic acid are potent widely used anti-inflammatory drugs. They thought to exert their therapeutic effects through multiple mechanisms, including the inhibition of cyclo-oxygenases, modulation NF-κB activity, direct activation AMPK. However, full spectrum activities is incompletely understood. Here we show that salicylate specifically inhibits CBP p300 lysine acetyltransferase activity in vitro by competition with acetyl-Coenzyme A at catalytic site. We a chemical...
We report that Histone Deacetylase 7 (HDAC7) controls the thymic effector programming of Natural Killer T (NKT) cells, and interference with this function contributes to tissue-specific autoimmunity. Gain HDAC7 in thymocytes blocks both negative selection NKT development, diverts Vα14/Jα18 TCR transgenic into a Tconv-like lineage. Conversely, deletion promotes thymocyte apoptosis causes expansion innate-effector cells. Investigating mechanisms involved, we found binds PLZF modulates...
Innate lymphoid cells (ILCs) have emerged as critical tissue-resident lymphocytes that coordinate responses to environmental stress and injury. Traditionally, their function was thought mirror adaptive respond specific pathogens. However, recent work has uncovered a more central role for ILCs in maintaining homeostasis even the absence of infection. are now better conceptualized an rheostat helps maintain local tissue setpoint during challenge by integrating sensory stimuli direct...
Abstract We report that Histone Deacetylase 7 (HDAC7) controls the thymic effector programming of Natural Killer T (NKT) cells, and interference with this function contributes to tissue-specific autoimmunity. Gain HDAC7 in thymocytes blocks both negative selection NKT development, diverting these cells into a Tconv-like lineage. Conversely, deletion promotes thymocyte apoptosis causes aberrant expansion innate-effector cells. Investigating mechanisms involved, we found binds PLZF modulates...